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(Received for publication, July 31, 1995; and in revised form, November 28, 1995) The complete deduced primary structure of mouse brain testican
has been established from cDNA cloning. The cDNA encodes a polypeptide
of 442 amino acids belonging to the proteoglycan family. The mouse
brain testican core protein is 95% identical to its human testicular
counterpart. In situ hybridization investigations revealed
that mouse testican mRNA is mainly present in a subpopulation of
pyramidal neurons localized in the CA3 area of the hippocampus. An
immunocytochemical approach, with antibodies directed against an
overexpressed chimeric antigen, produced in bacterial systems, showed
that testican is associated with the postsynaptic region of these
pyramidal neurons. Testican includes several putative functional
domains related to extracellular or pericellular proteins associated
with binding and/or regulatory functions. On the basis of its
structural organization and its occurrence in postsynaptic areas, this
proteoglycan might contribute to various neuronal mechanisms in the
central nervous system.
Volume 271,
Number 8,
Issue of February 23, 1996 pp. 4373-4380
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
ASSOCIATION WITH THE POSTSYNAPTIC AREA OF HIPPOCAMPUS PYRAMIDAL
CELLS
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