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(Received for publication, November 1, 1995) In Drosophila melanogaster, the frizzled gene
plays an essential role in the development of tissue polarity as
assessed by the orientation of cuticular structures. Through a
combination of random cDNA sequencing, degenerate polymerase chain
reaction amplification, and low stringency hybridization we have
identified six novel frizzled homologues from mammals, at
least 11 from zebrafish, several from chicken and sea urchin, and one
from Caenorhabditis elegans. The complete deduced amino acid
sequences of the mammalian and nematode homologues share with the Drosophila frizzled protein a conserved amino-terminal
cysteine-rich domain and seven putative transmembrane segments. Each of
the mammalian homologues is expressed in a distinctive set of tissues
in the adult, and at least three are expressed during embryogenesis. As
hypothesized for the Drosophila frizzled protein, the frizzled homologues are likely to act as transmembrane
receptors for as yet unidentified ligands. These observations predict
the existence of a family of signal transduction pathways that are
homologous to the pathway that determines tissue polarity in Drosophila.
Volume 271,
Number 8,
Issue of February 23, 1996 pp. 4468-4476
©1996 by The American Society for Biochemistry and Molecular Biology, Inc.
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C. Lee, L. Buttitta, N. May, A Kispert, and C. Fan SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm Development, January 1, 2000; 127(1): 109 - 118. [Abstract] [PDF]
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X. Liu, T. Liu, D. C. Slusarski, J. Yang-Snyder, C. C. Malbon, R. T. Moon, and H.-y. Wang Activation of a Frizzled-2/beta -adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galpha o and Galpha t PNAS, December 7, 1999; 96(25): 14383 - 14388. [Abstract] [Full Text] [PDF]
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T. Liu, X. Liu, H.-y. Wang, R. T. Moon, and C. C. Malbon Activation of Rat Frizzled-1 Promotes Wnt Signaling and Differentiation of Mouse F9 Teratocarcinoma Cells via Pathways That Require Galpha q and Galpha o Function J. Biol. Chem., November 19, 1999; 274(47): 33539 - 33544. [Abstract] [Full Text] [PDF]
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J. P.M Cleutjens, W.M. Blankesteijn, M. J.A.P Daemen, and J. F.M Smits The infarcted myocardium: Simply dead tissue, or a lively target for therapeutic interventions Cardiovasc Res, November 1, 1999; 44(2): 232 - 241. [Full Text] [PDF]
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H. Yuan, J. Mao, L. Li, and D. Wu Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation J. Biol. Chem., October 22, 1999; 274(43): 30419 - 30423. [Abstract] [Full Text] [PDF]
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J. R. McWhirter, S. T. C. Neuteboom, E. V. Wancewicz, B. P. Monia, J. R. Downing, and C. Murre Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia PNAS, September 28, 1999; 96(20): 11464 - 11469. [Abstract] [Full Text] [PDF]
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A Sato, T Kojima, K Ui-Tei, Y Miyata, and K Saigo Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants Development, January 10, 1999; 126(20): 4421 - 4430. [Abstract] [PDF]
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P Bhanot, M Fish, J. Jemison, R Nusse, J Nathans, and K. Cadigan Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development Development, January 9, 1999; 126(18): 4175 - 4186. [Abstract] [PDF]
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H Muller, R Samanta, and E Wieschaus Wingless signaling in the Drosophila embryo: zygotic r |
