| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, November 21, 1995; and in revised form, January 2, 1996)
The cAMP/cAMP-dependent protein kinase (A-kinase) and
Ca/calmodulin-dependent protein kinase (Cam-kinase)
signal transduction pathways are well known to regulate gene
transcription, but this has not been demonstrated directly for the
cGMP/cGMP-dependent protein kinase (G-kinase) signal transduction
pathway. Here we report that transfection of G-kinase into
G-kinase-deficient cells causes activation of the human c-fos promoter in a strictly cGMP-dependent manner. The effect of
G-kinase appeared to be mediated by several sequence elements, most
notably the serum response element (SRE), the AP-1 binding site (FAP),
and the cAMP response element (CRE). The magnitude of G-kinase
transactivation of the fos promoter was similar to that of
A-kinase, but there were significant differences between G-kinase and
A-kinase activation of single enhancer elements and of a chimeric
Gal4-CREB transcription factor. Our results indicate that G-kinase
transduces signals to the nucleus independently of A-kinase or
Ca
, although it may target some of the same
transcription factors as A-kinase and Cam-kinase.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Sugiura, H. Nakanishi, and J. D. Roberts Jr Proteolytic Processing of cGMP-Dependent Protein Kinase I Mediates Nuclear cGMP Signaling in Vascular Smooth Muscle Cells Circ. Res., July 3, 2008; 103(1): 53 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Roberts Jr., J.-D. Chiche, E. M. Kolpa, D. B. Bloch, and K. D. Bloch cGMP-dependent protein kinase I interacts with TRIM39R, a novel Rpp21 domain-containing TRIM protein Am J Physiol Lung Cell Mol Physiol, October 1, 2007; 293(4): L903 - L912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pisconti, S. Brunelli, M. Di Padova, C. De Palma, D. Deponti, S. Baesso, V. Sartorelli, G. Cossu, and E. Clementi Follistatin induction by nitric oxide through cyclic GMP: a tightly regulated signaling pathway that controls myoblast fusion J. Cell Biol., January 17, 2006; 172(2): 233 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Puzzo, O. Vitolo, F. Trinchese, J. P. Jacob, A. Palmeri, and O. Arancio Amyloid-{beta} Peptide Inhibits Activation of the Nitric Oxide/cGMP/cAMP-Responsive Element-Binding Protein Pathway during Hippocampal Synaptic Plasticity J. Neurosci., July 20, 2005; 25(29): 6887 - 6897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Broderick, V. Singh, S. Zhuang, A. Kambo, J. C. Chen, V. S. Sharma, R. B. Pilz, and G. R. Boss Nitric Oxide Scavenging by the Cobalamin Precursor Cobinamide J. Biol. Chem., March 11, 2005; 280(10): 8678 - 8685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wang, J. Skorczewski, X. Feng, L. Mei, and J. E. Murphy-Ullrich Glucose Up-regulates Thrombospondin 1 Gene Transcription and Transforming Growth Factor-{beta} Activity through Antagonism of cGMP-dependent Protein Kinase Repression via Upstream Stimulatory Factor 2 J. Biol. Chem., August 13, 2004; 279(33): 34311 - 34322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Subbaramaiah, K. Yoshimatsu, E. Scherl, K. M. Das, K. D. Glazier, D. Golijanin, R. A. Soslow, T. Tanabe, H. Naraba, and A. J. Dannenberg Microsomal Prostaglandin E Synthase-1 Is Overexpressed in Inflammatory Bowel Disease: EVIDENCE FOR INVOLVEMENT OF THE TRANSCRIPTION FACTOR Egr-1 J. Biol. Chem., March 26, 2004; 279(13): 12647 - 12658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zhuang, G. T. Nguyen, Y. Chen, T. Gudi, M. Eigenthaler, T. Jarchau, U. Walter, G. R. Boss, and R. B. Pilz Vasodilator-stimulated Phosphoprotein Activation of Serum-response Element-dependent Transcription Occurs Downstream of RhoA and Is Inhibited by cGMP-dependent Protein Kinase Phosphorylation J. Biol. Chem., March 12, 2004; 279(11): 10397 - 10407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Pilz and D. E. Casteel Regulation of Gene Expression by Cyclic GMP Circ. Res., November 28, 2003; 93(11): 1034 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Feil, S. M. Lohmann, H. de Jonge, U. Walter, and F. Hofmann Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System: Insights From Genetically Modified Mice Circ. Res., November 14, 2003; 93(10): 907 - 916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Salinas, L. Sparkman, K. Berhane, and V. Boggaram Nitric oxide inhibits surfactant protein B gene expression in lung epithelial cells Am J Physiol Lung Cell Mol Physiol, November 1, 2003; 285(5): L1153 - L1165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Marcet-Palacios, K. Graham, C. Cass, A. D. Befus, I. Mayers, and M. W. Radomski Nitric Oxide and Cyclic GMP Increase the Expression of Matrix Metalloproteinase-9 in Vascular Smooth Muscle J. Pharmacol. Exp. Ther., October 1, 2003; 307(1): 429 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, S. Zhuang, S. Cassenaer, D. E. Casteel, T. Gudi, G. R. Boss, and R. B. Pilz Synergism between Calcium and Cyclic GMP in Cyclic AMP Response Element-Dependent Transcriptional Regulation Requires Cooperation between CREB and C/EBP-{beta} Mol. Cell. Biol., June 15, 2003; 23(12): 4066 - 4082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-L. Chien, K.-C. Liang, C.-M. Teng, S.-C. Kuo, F.-Y. Lee, and W.-M. Fu Enhancement of Long-Term Potentiation by a Potent Nitric Oxide-Guanylyl Cyclase Activator, 3-(5-Hydroxymethyl-2-furyl)-1-benzyl-indazole Mol. Pharmacol., June 1, 2003; 63(6): 1322 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kietzmann, A. Samoylenko, and S. Immenschuh Transcriptional Regulation of Heme Oxygenase-1 Gene Expression by MAP Kinases of the JNK and p38 Pathways in Primary Cultures of Rat Hepatocytes J. Biol. Chem., May 9, 2003; 278(20): 17927 - 17936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Sauzeau, M. Rolli-Derkinderen, C. Marionneau, G. Loirand, and P. Pacaud RhoA Expression Is Controlled by Nitric Oxide through cGMP-dependent Protein Kinase Activation J. Biol. Chem., March 7, 2003; 278(11): 9472 - 9480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Chen, S. Zhuang, T. H. Nguyen, G. R. Boss, and R. B. Pilz Oncogenic Ras Leads to Rho Activation by Activating the Mitogen-activated Protein Kinase Pathway and Decreasing Rho-GTPase-activating Protein Activity J. Biol. Chem., January 24, 2003; 278(5): 2807 - 2818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gudi, J. C. Chen, D. E. Casteel, T. M. Seasholtz, G. R. Boss, and R. B. Pilz cGMP-dependent Protein Kinase Inhibits Serum-response Element-dependent Transcription by Inhibiting Rho Activation and Functions J. Biol. Chem., September 27, 2002; 277(40): 37382 - 37393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-F. Lu and R. D. Hawkins Ryanodine Receptors Contribute to cGMP-Induced Late-Phase LTP and CREB Phosphorylation in the Hippocampus J Neurophysiol, September 1, 2002; 88(3): 1270 - 1278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Casteel, S. Zhuang, T. Gudi, J. Tang, M. Vuica, S. Desiderio, and R. B. Pilz cGMP-dependent Protein Kinase Ibeta Physically and Functionally Interacts with the Transcriptional Regulator TFII-I J. Biol. Chem., August 23, 2002; 277(35): 32003 - 32014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Leach, S. M. Black, R. K. Schmidt-Ullrich, and R. B. Mikkelsen Activation of Constitutive Nitric-oxide Synthase Activity Is an Early Signaling Event Induced by Ionizing Radiation J. Biol. Chem., May 3, 2002; 277(18): 15400 - 15406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Lincoln, N. Dey, and H. Sellak Signal Transduction in Smooth Muscle: Invited Review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression J Appl Physiol, September 1, 2001; 91(3): 1421 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Ferreyra and D. A. Golombek Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1348 - R1355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hanada, Y. Terada, S. Inoshita, S. Sasaki, S. M. Lohmann, A. Smolenski, and F. Marumo Overexpression of protein kinase G using adenovirus inhibits cyclin E transcription and mesangial cell cycle Am J Physiol Renal Physiol, May 1, 2001; 280(5): F851 - F859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Cornwell, J. Li, H. Sellak, P. de Lanerolle, W. H. Rodgers, R. T. Miller, and R. Ann Word Regulation of Cyclic Guanosine Monophosphate-Dependent Protein Kinase in Human Uterine Tissues During the Menstrual Cycle Biol Reprod, March 1, 2001; 64(3): 857 - 864. [Abstract] [Full Text]
|
|
|
|
 |
|
 J.-W. Soh, Y. Mao, M.-G. Kim, R. Pamukcu, H. Li, G. A. Piazza, W. J. Thompson, and I. B. Weinstein Cyclic GMP Mediates Apoptosis Induced by Sulindac Derivatives via Activation of c-Jun NH2-Terminal Kinase 1 Clin. Cancer Res., October 1, 2000; 6(10): 4136 - 4141. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. A. Lucas, G. M. Pitari, S. Kazerounian, I. Ruiz-Stewart, J. Park, S. Schulz, K. P. Chepenik, and S. A. Waldman Guanylyl Cyclases and Signaling by Cyclic GMP Pharmacol. Rev., September 1, 2000; 52(3): 375 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Roberts Jr, J.-D. Chiche, J. Weimann, W. Steudel, W. M. Zapol, and K. D. Bloch Nitric Oxide Inhalation Decreases Pulmonary Artery Remodeling in the Injured Lungs of Rat Pups Circ. Res., July 21, 2000; 87(2): 140 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Browning, M. P. McShane, C. Marty, and R. D. Ye Nitric Oxide Activation of p38 Mitogen-activated Protein Kinase in 293T Fibroblasts Requires cGMP-dependent Protein Kinase J. Biol. Chem., January 28, 2000; 275(4): 2811 - 2816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Gertzberg, R. Clements, I. Jaspers, T. J. Ferro, P. Neumann, E. Flescher, and A. Johnson Tumor Necrosis Factor-alpha -Induced Activating Protein-1 Activity Is Modulated by Nitric Oxide-Mediated Protein Kinase G Activation Am. J. Respir. Cell Mol. Biol., January 1, 2000; 22(1): 105 - 115. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. Moon, Y.-K. Sung, R. Reddy, and G. V. Ronnett Odorants induce the phosphorylation of the cAMP response element binding protein in olfactory receptor neurons PNAS, December 7, 1999; 96(25): 14605 - 14610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. GUDI, G. K.-P. HONG, A. B. VAANDRAGER, S. M. LOHMANN, and R. B. PILZ Nitric oxide and cGMP regulate gene expression in neuronal and glial cells by activating type II cGMP-dependent protein kinase FASEB J, December 1, 1999; 13(15): 2143 - 2152. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-F. Lu, E. R. Kandel, and R. D. Hawkins Nitric Oxide Signaling Contributes to Late-Phase LTP and CREB Phosphorylation in the Hippocampus J. Neurosci., December 1, 1999; 19(23): 10250 - 10261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Komalavilas, P. K. Shah, H. Jo, and T. M. Lincoln Activation of Mitogen-activated Protein Kinase Pathways by Cyclic GMP and Cyclic GMP-dependent Protein Kinase in Contractile Vascular Smooth Muscle Cells J. Biol. Chem., November 26, 1999; 274(48): 34301 - 34309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Idriss, T. Gudi, D. E. Casteel, V. G. Kharitonov, R. B. Pilz, and G. R. Boss Nitric Oxide Regulation of Gene Transcription via Soluble Guanylate Cyclase and Type I cGMP-dependent Protein Kinase J. Biol. Chem., April 2, 1999; 274(14): 9489 - 9493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Bao, C. Lu, and J. A. Frangos Temporal Gradient in Shear But Not Steady Shear Stress Induces PDGF-A and MCP-1 Expression in Endothelial Cells : Role of NO, NF{kappa}B, and egr-1 Arterioscler. Thromb. Vasc. Biol., April 1, 1999; 19(4): 996 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Collins and M. D. Uhler Cyclic AMP- and Cyclic GMP-dependent Protein Kinases Differ in Their Regulation of Cyclic AMP Response Element-dependent Gene Transcription J. Biol. Chem., March 26, 1999; 274(13): 8391 - 8404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Suhasini, H. Li, S. M. Lohmann, G. R. Boss, and R. B. Pilz Cyclic-GMP-Dependent Protein Kinase Inhibits the Ras/Mitogen-Activated Protein Kinase Pathway Mol. Cell. Biol., December 1, 1998; 18(12): 6983 - 6994. [Abstract] [Full Text]
|
|
|
|
|
|
J. Hood and H. J. Granger Protein Kinase G Mediates Vascular Endothelial Growth Factor-induced Raf-1 Activation and Proliferation in Human Endothelial Cells J. Biol. Chem., September 4, 1998; 273(36): 23504 - 23508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wakisaka, N. Suzuki, M. Takeno, Y. Takeba, H. Nagafuchi, N. Saito, H. Hashimoto, T. Tomita, T. Ochi, and T. Sakane Involvement of simultaneous multiple transcription factor expression, including cAMP responsive element binding protein and OCT-1, for synovial cell outgrowth in patients with rheumatoid arthritis Ann Rheum Dis, August 1, 1998; 57(8): 487 - 494. [Abstract] [Full Text]
|
|
|
|
|
|
D. Beitner-Johnson and D. E. Millhorn Hypoxia Induces Phosphorylation of the Cyclic AMP Response Element-binding Protein by a Novel Signaling Mechanism J. Biol. Chem., July 31, 1998; 273(31): 19834 - 19839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Casteel, M. Suhasini, T. Gudi, R. Naima, and R. B. Pilz Regulation of the Erythroid Transcription Factor NF-E2 by Cyclic Adenosine Monophosphate-Dependent Protein Kinase Blood, May 1, 1998; 91(9): 3193 - 3201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Cordelier, J.-P. Esteve, C. Bousquet, N. Delesque, A.-M. O'Carroll, A. V. Schally, N. Vaysse, C. Susini, and L. Buscail Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5 PNAS, August 19, 1997; 94(17): 9343 - 9348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Di Fulvio, T. M. Lincoln, P. K. Lauf, and N. C. Adragna Protein Kinase G Regulates Potassium Chloride Cotransporter-3 Expression in Primary Cultures of Rat Vascular Smooth Muscle Cells J. Biol. Chem., June 8, 2001; 276(24): 21046 - 21052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Di Fulvio, P. K. Lauf, and N. C. Adragna Nitric Oxide Signaling Pathway Regulates Potassium Chloride Cotransporter-1 mRNA Expression in Vascular Smooth Muscle Cells J. Biol. Chem., November 21, 2001; 276(48): 44534 - 44540. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
