| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, July 9, 1996, and in revised form, August 30, 1996)
From the Tyrosinase, tyrosinase-related protein-1 (TRP-1),
and TRP-2 are the enzymes involved in melanin biosynthesis and are
preferentially expressed in pigment cells. Their human gene promoters
share the 11-base pair M box containing a CATGTG motif, which was shown here to be bound in vitro by microphthalmia-associated
transcription factor (MITF). Transient cotransfection analysis showed
that MITF overexpression increased the expression of a reporter gene
under the control of the human tyrosinase or TRP-1 gene promoter but not the TRP-2 promoter. The promoter activation caused by MITF is
dependent on each CATGTG motif of the distal enhancer element, the M
box, and the initiator E box of the tyrosinase gene and the TRP-1 M
box. Furthermore, a truncated MITF lacking the carboxyl-terminal 125 amino acid residues transactivated the tyrosinase promoter less
efficiently than did MITF, suggesting that MITF's carboxyl terminus
contains a transcriptional activation domain, but unexpectedly such a
truncated MITF remarkably transactivated the TRP-2 gene promoter. These
results suggest that MITF is sufficient to direct pigment cell-specific
transcription of the tyrosinase and TRP-1 genes but not the TRP-2
gene.
Volume 272, Number 1,
Issue of January 3, 1997
pp. 503-509
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
,
,
,
Department of Applied Physiology and
Molecular Biology, Tohoku University School of Medicine, Aoba-ku,
Sendai, Miyagi 980-77 and the § Department of Dermatology,
Akita University School of Medicine, Akita 010, Japan
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Takeda, T. Adachi, F. Han, S. Yokoyama, H. Yamamoto, W. Hida, and S. Shibahara Augmented Chemosensitivity in Black-Eyed White Mitf mi-bw Mice, Lacking Melanocytes J. Biochem., March 1, 2007; 141(3): 327 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Esumi, S. Kachi, P. A. Campochiaro, and D. J. Zack VMD2 Promoter Requires Two Proximal E-box Sites for Its Activity in Vivo and Is Regulated by the MITF-TFE Family J. Biol. Chem., January 19, 2007; 282(3): 1838 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. L. de la Serna, Y. Ohkawa, C. Higashi, C. Dutta, J. Osias, N. Kommajosyula, T. Tachibana, and A. N. Imbalzano The Microphthalmia-associated Transcription Factor Requires SWI/SNF Enzymes to Activate Melanocyte-specific Genes J. Biol. Chem., July 21, 2006; 281(29): 20233 - 20241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fang, K. Leishear, T. K. Nguyen, R. Finko, K. Cai, M. Fukunaga, L. Li, P. A. Brafford, A. N. Kulp, X. Xu, et al. Defining the Conditions for the Generation of Melanocytes from Human Embryonic Stem Cells Stem Cells, July 1, 2006; 24(7): 1668 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhou, I. Ben-Efraim, J.-L. Bigcas, D. Junqueira, T. Wiedmer, and P. J. Sims Phospholipid Scramblase 1 Binds to the Promoter Region of the Inositol 1,4,5-Triphosphate Receptor Type 1 Gene to Enhance Its Expression J. Biol. Chem., October 14, 2005; 280(41): 35062 - 35068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lin, A. J. Gerth, and S. L. Peng Active Inhibition of Plasma Cell Development in Resting B Cells by Microphthalmia-associated Transcription Factor J. Exp. Med., November 8, 2004; (2004) jem.20040612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Esumi, Y. Oshima, Y. Li, P. A. Campochiaro, and D. J. Zack Analysis of the VMD2 Promoter and Implication of E-box Binding Factors in Its Regulation J. Biol. Chem., April 30, 2004; 279(18): 19064 - 19073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ohguchi, Y. Banno, Y. Akao, and Y. Nozawa Involvement of Phospholipase D1 in Melanogenesis of Mouse B16 Melanoma Cells J. Biol. Chem., January 30, 2004; 279(5): 3408 - 3412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Elworthy, J. A. Lister, T. J. Carney, D. W. Raible, and R. N. Kelsh Transcriptional regulation of mitfa accounts for the sox10 requirement in zebrafish melanophore development Development, June 15, 2003; 130(12): 2809 - 2818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Martinez-Morales, V. Dolez, I. Rodrigo, R. Zaccarini, L. Leconte, P. Bovolenta, and S. Saule OTX2 Activates the Molecular Network Underlying Retina Pigment Epithelium Differentiation J. Biol. Chem., June 6, 2003; 278(24): 21721 - 21731. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-S. Kim, E.-S. Hwang, J.-E. Lee, S.-Y. Kim, S.-B. Kwon, and K.-C. Park Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation J. Cell Sci., May 1, 2003; 116(9): 1699 - 1706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Hari, V. Brault, M. Kleber, H.-Y. Lee, F. Ille, R. Leimeroth, C. Paratore, U. Suter, R. Kemler, and L. Sommer Lineage-specific requirements of {beta}-catenin in neural crest development J. Cell Biol., December 9, 2002; 159(5): 867 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Widlund, M. A. Horstmann, E. R. Price, J. Cui, S. L. Lessnick, M. Wu, X. He, and D. E. Fisher {beta}-Catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor J. Cell Biol., September 16, 2002; 158(6): 1079 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Khaled, L. Larribere, K. Bille, E. Aberdam, J.-P. Ortonne, R. Ballotti, and C. Bertolotto Glycogen Synthase Kinase 3beta Is Activated by cAMP and Plays an Active Role in the Regulation of Melanogenesis J. Biol. Chem., September 6, 2002; 277(37): 33690 - 33697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Saito, K.-i. Yasumoto, K. Takeda, K. Takahashi, A. Fukuzaki, S. Orikasa, and S. Shibahara Melanocyte-specific Microphthalmia-associated Transcription Factor Isoform Activates Its Own Gene Promoter through Physical Interaction with Lymphoid-enhancing Factor 1 J. Biol. Chem., August 2, 2002; 277(32): 28787 - 28794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fang, Y. Tsuji, and V. Setaluri Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF Nucleic Acids Res., July 15, 2002; 30(14): 3096 - 3106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Kamaraju, C. Bertolotto, J. Chebath, and M. Revel Pax3 Down-regulation and Shut-off of Melanogenesis in Melanoma B16/F10.9 by Interleukin-6 Receptor Signaling J. Biol. Chem., April 19, 2002; 277(17): 15132 - 15141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Selzer, V. Wacheck, T. Lucas, E. Heere-Ress, M. Wu, K. N. Weilbaecher, W. Schlegel, P. Valent, F. Wrba, H. Pehamberger, et al. The Melanocyte-specific Isoform of the Microphthalmia Transcription Factor Affects the Phenotype of Human Melanoma Cancer Res., April 1, 2002; 62(7): 2098 - 2103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. V. BOTCHKAREVA, M. KHLGATIAN, B. J. LONGLEY, V. A. BOTCHKAREV, and B. A. GILCHREST SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit FASEB J, March 1, 2001; 15(3): 645 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. I. Salti, T. Manougian, M. Farolan, A. Shilkaitis, D. Majumdar, and T. K. Das Gupta Micropthalmia Transcription Factor: A New Prognostic Marker in Intermediate-thickness Cutaneous Malignant Melanoma Cancer Res., September 1, 2000; 60(18): 5012 - 5016. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. Bondurand, V. Pingault, D. E. Goerich, N. Lemort, E. Sock, C. L. Caignec, M. Wegner, and M. Goossens Interaction among SOX10, PAX3 and MITF, three genes altered in Waardenburg syndrome Hum. Mol. Genet., August 12, 2000; 9(13): 1907 - 1917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Verastegui, C. Bertolotto, K. Bille, P. Abbe, J. P. Ortonne, and R. Ballotti TFE3, a Transcription Factor Homologous to Microphthalmia, Is a Potential Transcriptional Activator of Tyrosinase and TyrpI Genes Mol. Endocrinol., March 1, 2000; 14(3): 449 - 456. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. I. Dorsky, D. W. Raible, and R. T. Moon Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway Genes & Dev., January 15, 2000; 14(2): 158 - 162. [Abstract] [Full Text]
|
|
|
|
|
|
L Hou, J. Panthier, and H Arnheiter Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF Development, January 12, 2000; 127(24): 5379 - 5389. [Abstract] [PDF]
|
|
|
|
|
|
S Fuhrmann, E. Levine, and T. Reh Extraocular mesenchyme patterns the optic vesicle during early eye development in the embryonic chick Development, January 11, 2000; 127(21): 4599 - 4609. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Rehli, A. Lichanska, A. I. Cassady, M. C. Ostrowski, and D. A. Hume TFEC Is a Macrophage-Restricted Member of the Microphthalmia-TFE Subfamily of Basic Helix-Loop-Helix Leucine Zipper Transcription Factors J. Immunol., February 1, 1999; 162(3): 1559 - 1565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lister, C. Robertson, T Lepage, S. Johnson, and D. Raible nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate Development, January 9, 1999; 126(17): 3757 - 3767. [Abstract] [PDF]
|
|
|
|
 |
|
 I. Aksan and C. R. Goding Targeting the Microphthalmia Basic Helix-Loop-Helix-Leucine Zipper Transcription Factor to a Subset of E-Box Elements In Vitro and In Vivo Mol. Cell. Biol., December 1, 1998; 18(12): 6930 - 6938. [Abstract] [Full Text]
|
|
|
|
|
|
C. Bertolotto, R. Buscà, P. Abbe, K. Bille, E. Aberdam, J.-P. Ortonne, and R. Ballotti Different cis-Acting Elements Are Involved in the Regulation of TRP1 and TRP2 Promoter Activities by Cyclic AMP: Pivotal Role of M Boxes (GTCATGTGCT) and of Microphthalmia Mol. Cell. Biol., February 1, 1998; 18(2): 694 - 702. [Abstract] [Full Text]
|
|
|
|
|
|
K. Takeda, K.-i. Yasumoto, R. Takada, S. Takada, K.-i. Watanabe, T. Udono, H. Saito, K. Takahashi, and S. Shibahara Induction of Melanocyte-specific Microphthalmia-associated Transcription Factor by Wnt-3a J. Biol. Chem., May 5, 2000; 275(19): 14013 - 14016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Carreira, B. Liu, and C. R. Goding The Gene Encoding the T-box Factor Tbx2 Is a Target for the Microphthalmia-associated Transcription Factor in Melanocytes J. Biol. Chem., July 14, 2000; 275(29): 21920 - 21927. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
