HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Song, H. H. Articles by Filmus, J. Search for Related Content PubMed PubMed Citation Articles by Song, H. H. Articles by Filmus, J. Social Bookmarking                      What's this?

Volume 272, Number 12, Issue of March 21, 1997 pp. 7574-7577
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

---

COMMUNICATION:
OCI-5/Rat Glypican-3 Binds to Fibroblast Growth Factor-2 but Not to Insulin-like Growth Factor-2

(Received for publication, November 15, 1996, and in revised form, January 21, 1997)

From the ^§ Division of Cancer Biology Research, Sunnybrook Health Science Centre and the ^‡ Department of Medical Biophysics, University of Toronto, Toronto, Ontario M4N 3M5, Canada

OCI-5 encodes the rat homologue of glypican-3, a membrane-bound heparan sulfate proteoglycan that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome. OCI-5 and glypican-3 are 95% identical. It has been recently suggested that glypican-3 interacts with insulin-like growth factor-2 (IGF-2) and that this interaction regulates IGF-2 activity. We report here that we have transfected OCI-5 into two different cell lines, and we have not been able to detect an interaction between the OCI-5 proteoglycan produced by the transfected cells and IGF-2. On the other hand, we have found that OCI-5 interacts with FGF-2, as has already been shown for glypican-1. This interaction is mediated by the heparan sulfate chains of OCI-5 because it can be inhibited by heparin or by heparitinase.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				G. Su, K. Meyer, C. D. Nandini, D. Qiao, S. Salamat, and A. Friedl Glypican-1 Is Frequently Overexpressed in Human Gliomas and Enhances FGF-2 Signaling in Glioma Cells Am. J. Pathol., June 1, 2006; 168(6): 2014 - 2026. [Abstract] [Full Text] [PDF]

				H. H. Song, W. Shi, Y.-Y. Xiang, and J. Filmus The Loss of Glypican-3 Induces Alterations in Wnt Signaling J. Biol. Chem., January 21, 2005; 280(3): 2116 - 2125. [Abstract] [Full Text] [PDF]

				M. Capurro, J. Filmus, Y. Hippo, H. Aburatani, and H. Satoh Glypican-3 as a Serum Marker for Hepatocellular Carcinoma Cancer Res., January 1, 2005; 65(1): 372 - 373. [Full Text] [PDF]

				H. Kim, G.-L. Xu, A. C. Borczuk, S. Busch, J. Filmus, M. Capurro, J. S. Brody, J. Lange, J. M. D'Armiento, P. B. Rothman, et al. The Heparan Sulfate Proteoglycan GPC3 Is a Potential Lung Tumor Suppressor Am. J. Respir. Cell Mol. Biol., December 1, 2003; 29(6): 694 - 701. [Abstract] [Full Text] [PDF]

				C. E. Bandtlow and D. R. Zimmermann Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins Physiol Rev, October 1, 2000; 80(4): 1267 - 1290. [Abstract] [Full Text] [PDF]

				M. Veugelers, B. D. Cat, S. Y. Muyldermans, G. Reekmans, N. Delande, S. Frints, E. Legius, J.-P. Fryns, C. Schrander-Stumpel, B. Weidle, et al. Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene Hum. Mol. Genet., May 22, 2000; 9(9): 1321 - 1328. [Abstract] [Full Text] [PDF]

				A. D. Lander and S. B. Selleck The Elusive Functions of Proteoglycans: In Vivo Veritas J. Cell Biol., January 24, 2000; 148(2): 227 - 232. [Abstract] [Full Text] [PDF]

				D. F. Cano-Gauci, H. H. Song, H. Yang, C. McKerlie, B. Choo, W. Shi, R. Pullano, T. D. Piscione, S. Grisaru, S. Soon, et al. Glypican-3–deficient Mice Exhibit Developmental Overgrowth and Some of the Abnormalities Typical of Simpson-Golabi-Behmel Syndrome J. Cell Biol., July 12, 1999; 146(1): 255 - 264. [Abstract] [Full Text] [PDF]

				S. Gengrinovitch, B. Berman, G. David, L. Witte, G. Neufeld, and D. Ron Glypican-1 Is a VEGF165 Binding Proteoglycan That Acts as an Extracellular Chaperone for VEGF165 J. Biol. Chem., April 16, 1999; 274(16): 10816 - 10822. [Abstract] [Full Text] [PDF]

				J. Y Xuan, R. M Hughes-Benzie, and A. E MacKenzie A small interstitial deletion in the GPC3 gene causes Simpson-Golabi-Behmel syndrome in a Dutch-Canadian family J. Med. Genet., January 1, 1999; 36(1): 57 - 58. [Abstract] [Full Text]

				A. D. Gonzalez, M. Kaya, W. Shi, H. Song, J. R. Testa, L. Z. Penn, and J. Filmus OCI-5/GPC3, a Glypican Encoded by a Gene That Is Mutated in the Simpson-Golabi-Behmel Overgrowth Syndrome, Induces Apoptosis in a Cell Line-specific Manner J. Cell Biol., June 15, 1998; 141(6): 1407 - 1414. [Abstract] [Full Text] [PDF]

				C. Perollet, Z. C. Han, C. Savona, J. P. Caen, and A. Bikfalvi Platelet Factor 4 Modulates Fibroblast Growth Factor 2 (FGF-2) Activity and Inhibits FGF-2 Dimerization Blood, May 1, 1998; 91(9): 3289 - 3299. [Abstract] [Full Text] [PDF]

				J. Eggenschwiler, T. Ludwig, P. Fisher, P. A. Leighton, S. M. Tilghman, and A. Efstratiadis Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes Genes & Dev., December 1, 1997; 11(23): 3128 - 3142. [Abstract] [Full Text] [PDF]