| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
B-dependent
Mechanism
(Received for publication, September 3, 1996, and in revised form, December 20, 1996)
From the Department of Medicine, The Johns Hopkins University
School of Medicine, Baltimore, Maryland 21205
Activated macrophages play a critical role in
controlling chronic tissue inflammation through the release of a
variety of mediators including cytokines, chemokines, growth factors,
active lipids, reactive oxygen, and nitrogen species. The mechanisms that regulate macrophage activation in chronic inflammation are poorly
understood. A hallmark of chronic inflammation is the turnover of
extracellular matrix components, and recent work has suggested that
interactions with the extracellular matrix can exert important influences on macrophage effector functions. We have examined the
effect of low molecular weight fragments of the extracellular matrix
glycosaminoglycan hyaluronan (HA) on the induction of nitric-oxide synthase (iNOS) in macrophages. We found that HA fragments induce iNOS
mRNA, protein and activity alone, and markedly synergize with
interferon-
to induce iNOS gene expression in murine macrophages. In
addition, we found that resident tissue alveolar macrophages respond
minimally, but inflammatory alveolar macrophages exhibit a marked
induction in iNOS expression in response to HA fragments. Finally, we
demonstrate that the mechanism of HA fragment-induced expression of
iNOS requires activation of the transcriptional regulator nuclear
factor 
B. These data support the hypothesis that HA may be an
important regulator of macrophage activation at sites of chronic tissue
inflammation.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  D. R. Yager, R. A. Kulina, and L. A. Gilman Wound Fluids: A Window Into the Wound Environment? International Journal of Lower Extremity Wounds, December 1, 2007; 6(4): 262 - 272. [Abstract] [PDF]
|
|
|
|
 |
|
 P. L. Bollyky, J. D. Lord, S. A. Masewicz, S. P. Evanko, J. H. Buckner, T. N. Wight, and G. T. Nepom Cutting Edge: High Molecular Weight Hyaluronan Promotes the Suppressive Effects of CD4+CD25+ Regulatory T Cells J. Immunol., July 15, 2007; 179(2): 744 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Taylor, K. Yamasaki, K. A. Radek, A. D. Nardo, H. Goodarzi, D. Golenbock, B. Beutler, and R. L. Gallo Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2 J. Biol. Chem., June 22, 2007; 282(25): 18265 - 18275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Goueffic, C. Guilluy, P. Guerin, P. Patra, P. Pacaud, and G. Loirand Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation Cardiovasc Res, November 1, 2006; 72(2): 339 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Boodoo, E. W. Spannhake, J. D. Powell, and M. R. Horton Differential regulation of hyaluronan-induced IL-8 and IP-10 in airway epithelial cells Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L479 - L486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Scheibner, M. A. Lutz, S. Boodoo, M. J. Fenton, J. D. Powell, and M. R. Horton Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2 J. Immunol., July 15, 2006; 177(2): 1272 - 1281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Takemura, H. Itoh, N. Sagawa, S. Yura, D. Korita, K. Kakui, M. Kawamura, N. Hirota, H. Maeda, and S. Fujii Cyclic mechanical stretch augments hyaluronan production in cultured human uterine cervical fibroblast cells Mol. Hum. Reprod., September 1, 2005; 11(9): 659 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Ducale, S. I. Ward, T. Dechert, and D. R. Yager Regulation of hyaluronan synthase-2 expression in human intestinal mesenchymal cells: mechanisms of interleukin-1{beta}-mediated induction Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G462 - G470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-J. Bai, A. P. Spicer, M. M. Mascarenhas, L. Yu, C. D. Ochoa, H. G. Garg, and D. A. Quinn The Role of Hyaluronan Synthase 3 in Ventilator-induced Lung Injury Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 92 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xu, H. Kurihara, T. Ito, H. Kikuchi, K. Yoshida, H. Yamanokuchi, and A. Asari The Keratan Sulfate Disaccharide Gal(6S03) {beta}1,4-GlcNAc(6S03) Modulates Interleukin 12 Production by Macrophages in Murine Thy-1 Type Autoimmune Disease J. Biol. Chem., May 27, 2005; 280(21): 20879 - 20886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chai, Q. Chai, C. C. Danielsen, P. Hjorth, J. R. Nyengaard, T. Ledet, Y. Yamaguchi, L. M. Rasmussen, and L. Wogensen Overexpression of Hyaluronan in the Tunica Media Promotes the Development of Atherosclerosis Circ. Res., March 18, 2005; 96(5): 583 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Straach, J. M. Shelton, J. A. Richardson, V. C. Hascall, and M. S. Mahendroo Regulation of hyaluronan expression during cervical ripening Glycobiology, January 1, 2005; 15(1): 55 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Aoki, S. Matsumoto, Y. Hirayama, T. Wada, Y. Ozeki, M. Niki, P. Domenech, K. Umemori, S. Yamamoto, A. Mineda, et al. Extracellular Mycobacterial DNA-binding Protein 1 Participates in Mycobacterium-Lung Epithelial Cell Interaction through Hyaluronic Acid J. Biol. Chem., September 17, 2004; 279(38): 39798 - 39806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ohno-Nakahara, K. Honda, K. Tanimoto, N. Tanaka, T. Doi, A. Suzuki, K. Yoneno, Y. Nakatani, M. Ueki, S. Ohno, et al. Induction of CD44 and MMP Expression by Hyaluronidase Treatment of Articular Chondrocytes J. Biochem., May 1, 2004; 135(5): 567 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Stuhlmeier and C. Pollaschek Differential Effect of Transforming Growth Factor {beta} (TGF-{beta}) on the Genes Encoding Hyaluronan Synthases and Utilization of the p38 MAPK Pathway in TGF-{beta}-induced Hyaluronan Synthase 1 Activation J. Biol. Chem., March 5, 2004; 279(10): 8753 - 8760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Fieber, P. Baumann, R. Vallon, C. Termeer, J. C. Simon, M. Hofmann, P. Angel, P. Herrlich, and J. P. Sleeman Hyaluronan-oligosaccharide-induced transcription of metalloproteases J. Cell Sci., January 15, 2004; 117(2): 359 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Esnault and J. S. Malter Hyaluronic Acid or TNF-{alpha} Plus Fibronectin Triggers Granulocyte Macrophage-Colony-Stimulating Factor mRNA Stabilization in Eosinophils Yet Engages Differential Intracellular Pathways and mRNA Binding Proteins J. Immunol., December 15, 2003; 171(12): 6780 - 6787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Sugahara, T. Murai, H. Nishinakamura, H. Kawashima, H. Saya, and M. Miyasaka Hyaluronan Oligosaccharides Induce CD44 Cleavage and Promote Cell Migration in CD44-expressing Tumor Cells J. Biol. Chem., August 22, 2003; 278(34): 32259 - 32265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Eriksson, L. Dons, A. G. Rothfuchs, P. Heldin, H. Wigzell, and M. E. Rottenberg CD44-Regulated Intracellular Proliferation of Listeria monocytogenes Infect. Immun., July 1, 2003; 71(7): 4102 - 4111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Pummill and P. L. DeAngelis Alteration of Polysaccharide Size Distribution of a Vertebrate Hyaluronan Synthase by Mutation J. Biol. Chem., May 23, 2003; 278(22): 19808 - 19814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Wang, P. Teder, N. P. Judd, P. W. Noble, and C. M. Doerschuk CD44 Deficiency Leads to Enhanced Neutrophil Migration and Lung Injury in Escherichia coli Pneumonia in Mice Am. J. Pathol., December 1, 2002; 161(6): 2219 - 2228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Horton, S. Boodoo, and J. D. Powell NF-kappa B Activation Mediates the Cross-talk between Extracellular Matrix and Interferon-gamma (IFN-gamma ) Leading to Enhanced Monokine Induced by IFN-gamma (MIG) Expression in Macrophages J. Biol. Chem., November 8, 2002; 277(46): 43757 - 43762. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O.V. Evgenov, N.V. Evgenov, T.E. Mollnes, and L.J. Bjertnaes Methylene blue reduces pulmonary oedema and cyclo-oxygenase products in endotoxaemic sheep Eur. Respir. J., October 1, 2002; 20(4): 957 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yang, T. F. Witham, L. Villa, M. Erff, J. Attanucci, S. Watkins, D. Kondziolka, H. Okada, I. F. Pollack, and W. H. Chambers Glioma-associated Hyaluronan Induces Apoptosis in Dendritic Cells via Inducible Nitric Oxide Synthase: Implications for the Use of Dendritic Cells for Therapy of Gliomas Cancer Res., May 1, 2002; 62(9): 2583 - 2591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Termeer, H. Johannsen, T. Braun, A. Renkl, T. Ahrens, R. W. Denfeld, M. B. Lappin, J. M. Weiss, and J. C. Simon The role of CD44 during CD40 ligand-induced dendritic cell clustering and maturation J. Leukoc. Biol., November 1, 2001; 70(5): 715 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Levesque and B. F. Haynes Activated T Lymphocytes Regulate Hyaluronan Binding to Monocyte CD44 Via Production of IL-2 and IFN-{{gamma}} J. Immunol., January 1, 2001; 166(1): 188 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. D. Camenisch and J. A. McDonald Hyaluronan . Is Bigger Better? Am. J. Respir. Cell Mol. Biol., October 1, 2000; 23(4): 431 - 433. [Full Text]
|
|
|
|
|
|
Y. Ohkawara, G. Tamura, T. Iwasaki, A. Tanaka, T. Kikuchi, and K. Shirato Activation and Transforming Growth Factor-beta Production in Eosinophils by Hyaluronan Am. J. Respir. Cell Mol. Biol., October 1, 2000; 23(4): 444 - 451. [Abstract] [Full Text]
|
|
|
|
|
|
R. C. Savani, G. Hou, P. Liu, C. Wang, E. Simons, P. C. Grimm, R. Stern, A. H. Greenberg, H. M. DeLisser, and N. Khalil A Role for Hyaluronan in Macrophage Accumulation and Collagen Deposition after Bleomycin-Induced Lung Injury Am. J. Respir. Cell Mol. Biol., October 1, 2000; 23(4): 475 - 484. [Abstract] [Full Text]
|
|
|
|
|
|
M. R. Horton, M. A. Olman, C. Bao, K. E. White, A. M. K. Choi, B.-Y. Chin, P. W. Noble, and C. J. Lowenstein Regulation of plasminogen activator inhibitor-1 and urokinase by hyaluronan fragments in mouse macrophages Am J Physiol Lung Cell Mol Physiol, October 1, 2000; 279(4): L707 - L715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Termeer, J. Hennies, U. Voith, T. Ahrens, J. M. Weiss, P. Prehm, and J. C. Simon Oligosaccharides of Hyaluronan Are Potent Activators of Dendritic Cells J. Immunol., August 15, 2000; 165(4): 1863 - 1870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Fitzgerald, A. G. Bowie, B. S. Skeffington, and L. A. J. O'Neill Ras, Protein Kinase C{zeta}, and I{kappa}B Kinases 1 and 2 Are Downstream Effectors of CD44 During the Activation of NF-{kappa}B by Hyaluronic Acid Fragments in T-24 Carcinoma Cells J. Immunol., February 15, 2000; 164(4): 2053 - 2063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Novak, S. S. Stylli, A. H. Kaye, and G. Lepperdingerm Hyaluronidase-2 Overexpression Accelerates Intracerebral but not Subcutaneous Tumor Formation of Murine Astrocytoma Cells Cancer Res., December 1, 1999; 59(24): 6246 - 6250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Wuthrich The proinflammatory role of hyaluronan-CD44 interactions in renal injury Nephrol. Dial. Transplant., November 1, 1999; 14(11): 2554 - 2556. [Full Text] [PDF]
|
|
|
|
|
|
K. A. Fitzgerald and L. A. J. O'Neill Characterization of CD44 Induction by IL-1: A Critical Role for Egr-1 J. Immunol., April 15, 1999; 162(8): 4920 - 4927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Horton, S. Shapiro, C. Bao, C. J. Lowenstein, and P. W. Noble Induction and Regulation of Macrophage Metalloelastase by Hyaluronan Fragments in Mouse Macrophages J. Immunol., April 1, 1999; 162(7): 4171 - 4176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Horton, C. M. McKee, C. Bao, F. Liao, J. M. Farber, J. Hodge-DuFour, E. Pure, B. L. Oliver, T. M. Wright, and P. W. Noble Hyaluronan Fragments Synergize with Interferon-gamma to Induce the C-X-C Chemokines Mig and Interferon-inducible Protein-10 in Mouse Macrophages J. Biol. Chem., December 25, 1998; 273(52): 35088 - 35094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Oertli, B. Beck-Schimmer, X. Fan, and R. P. Wuthrich Mechanisms of Hyaluronan-Induced Up-Regulation of ICAM-1 and VCAM-1 Expression by Murine Kidney Tubular Epithelial Cells: Hyaluronan Triggers Cell Adhesion Molecule Expression Through a Mechanism Involving Activation of Nuclear Factor-{kappa}B and Activating Protein-1 J. Immunol., October 1, 1998; 161(7): 3431 - 3437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lepperdinger, B. Strobl, and G. Kreil HYAL2, a Human Gene Expressed in Many Cells, Encodes a Lysosomal Hyaluronidase with a Novel Type of Specificity J. Biol. Chem., August 28, 1998; 273(35): 22466 - 22470. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ilangumaran, A. Briol, and D. C. Hoessli CD44 Selectively Associates With Active Src Family Protein Tyrosine Kinases Lck and Fyn in Glycosphingolipid-Rich Plasma Membrane Domains of Human Peripheral Blood Lymphocytes Blood, May 15, 1998; 91(10): 3901 - 3908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Horton, M. D. Burdick, R. M. Strieter, C. Bao, and P. W. Noble Regulation of Hyaluronan-Induced Chemokine Gene Expression by IL-10 and IFN-{gamma} in Mouse Macrophages J. Immunol., March 15, 1998; 160(6): 3023 - 3030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Yu, B. P. Toole, and I. Stamenkovic Induction of Apoptosis of Metastatic Mammary Carcinoma Cells In Vivo by Disruption of Tumor Cell Surface CD44 Function J. Exp. Med., December 15, 1997; 186(12): 1985 - 1996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lesley, V. C. Hascall, M. Tammi, and R. Hyman Hyaluronan Binding by Cell Surface CD44 J. Biol. Chem., August 25, 2000; 275(35): 26967 - 26975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Li, N. Wong, M. D. Jabali, and P. Johnson CD44-initiated Cell Spreading Induces Pyk2 Phosphorylation, Is Mediated by Src Family Kinases, and Is Negatively Regulated by CD45 J. Biol. Chem., July 27, 2001; 276(31): 28767 - 28773. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
