HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Orth, K. Articles by Dixit, V. M. Search for Related Content PubMed PubMed Citation Articles by Orth, K. Articles by Dixit, V. M. Social Bookmarking                      What's this?

Volume 272, Number 14, Issue of April 4, 1997 pp. 8841-8844
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

---

COMMUNICATION:
Bik and Bak Induce Apoptosis Downstream of CrmA but Upstream of Inhibitor of Apoptosis

(Received for publication, January 30, 1997, and in revised form, February 18, 1997)

From the Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109

Recent studies have identified a number of cell death pathway components. In this study, we describe the role that two such components, Bik and Bak, play in initiating the apoptotic program. These Bcl-2 family members engage the death pathway downstream of the block imposed by the serpin CrmA, but upstream of the block initiated by cellular inhibitors of apoptosis, which are a family of molecules characterized by a conserved baculovirus inhibitor of apoptosis repeat motif. Distal death pathway components activated by Bik and Bak are similar to those activated by the CD-95 (Fas/Apo1) and tumor necrosis factor death receptors.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				B. P. Eckelman and G. S. Salvesen The Human Anti-apoptotic Proteins cIAP1 and cIAP2 Bind but Do Not Inhibit Caspases J. Biol. Chem., February 10, 2006; 281(6): 3254 - 3260. [Abstract] [Full Text] [PDF]

				Y. Tong, Q. Yang, C. Vater, L.K. Venkatesh, D. Custeau, T. Chittenden, G. Chinnadurai, and H. Gourdeau The Pro-apoptotic Protein, Bik, Exhibits Potent Antitumor Activity That Is Dependent on Its BH3 Domain Mol. Cancer Ther., December 1, 2001; 1(2): 95 - 102. [Abstract] [Full Text] [PDF]

				A. Jiang and E. A. Clark Involvement of Bik, a Proapoptotic Member of the Bcl-2 Family, in Surface IgM-Mediated B Cell Apoptosis J. Immunol., May 15, 2001; 166(10): 6025 - 6033. [Abstract] [Full Text] [PDF]

				V. Marshansky, X. Wang, R. Bertrand, H. Luo, W. Duguid, G. Chinnadurai, N. Kanaan, M. D. Vu, and J. Wu Proteasomes Modulate Balance Among Proapoptotic and Antiapoptotic Bcl-2 Family Members and Compromise Functioning of the Electron Transport Chain in Leukemic Cells J. Immunol., March 1, 2001; 166(5): 3130 - 3142. [Abstract] [Full Text] [PDF]

				A. Pataer, B. Fang, R. Yu, S. Kagawa, K. K. Hunt, T. J. McDonnell, J. A. Roth, and S. G. Swisher Adenoviral Bak Overexpression Mediates Caspase-dependent Tumor Killing Cancer Res., February 1, 2000; 60(4): 788 - 792. [Abstract] [Full Text]

				Q. L. Deveraux and J. C. Reed IAP family proteins---suppressors of apoptosis Genes & Dev., February 1, 1999; 13(3): 239 - 252. [Full Text]

				C. A. Bradham, T. Qian, K. Streetz, C. Trautwein, D. A. Brenner, and J. J. Lemasters The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release Mol. Cell. Biol., November 1, 1998; 18(11): 6353 - 6364. [Abstract] [Full Text]

				H. Spets, P. Georgii-Hemming, J. Siljason, K. Nilsson, and H. Jernberg-Wiklund Fas/APO-1 (CD95)-Mediated Apoptosis Is Activated by Interferon-gamma and Interferon-alpha in Interleukin-6 (IL-6)-Dependent and IL-6-Independent Multiple Myeloma Cell Lines Blood, October 15, 1998; 92(8): 2914 - 2923. [Abstract] [Full Text] [PDF]

				O. Deas, C. Dumont, M. MacFarlane, M. Rouleau, C. Hebib, F. Harper, F. Hirsch, B. Charpentier, G. M. Cohen, and A. Senik Caspase-Independent Cell Death Induced by Anti-CD2 or Staurosporine in Activated Human Peripheral T Lymphocytes J. Immunol., October 1, 1998; 161(7): 3375 - 3383. [Abstract] [Full Text] [PDF]

				R. Hegde, S. M. Srinivasula, M. Ahmad, T. Fernandes-Alnemri, and E. S. Alnemri Blk, a BH3-containing Mouse Protein That Interacts with Bcl-2 and Bcl-xL, Is a Potent Death Agonist J. Biol. Chem., April 3, 1998; 273(14): 7783 - 7786. [Abstract] [Full Text] [PDF]

				L.-P. Wen, K. Madani, J. A. Fahrni, S. R. Duncan, and G. D. Rosen Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-gamma and Fas Am J Physiol Lung Cell Mol Physiol, November 1, 1997; 273(5): L921 - L929. [Abstract] [Full Text] [PDF]

				J. Doostzadeh-Cizeron, S. Yin, and D. W. Goodrich Apoptosis Induced by the Nuclear Death Domain Protein p84N5 Is Associated with Caspase-6 and NF-kappa B Activation J. Biol. Chem., August 11, 2000; 275(33): 25336 - 25341. [Abstract] [Full Text] [PDF]

				R. J. Clem, T.-T. Sheu, B. W. M. Richter, W.-W. He, N. A. Thornberry, C. S. Duckett, and J. M. Hardwick c-IAP1 Is Cleaved by Caspases to Produce a Proapoptotic C-terminal Fragment J. Biol. Chem., March 2, 2001; 276(10): 7602 - 7608. [Abstract] [Full Text] [PDF]