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Volume 272, Number 14, Issue of April 4, 1997 pp. 8905-8911
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

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The p120-v-Abl Protein Interacts with E2F-1 and Regulates E2F-1 Transcriptional Activity

(Received for publication, September 19, 1996, and in revised form, November 20, 1996)

From the ^¶ Laboratory of Chemoprevention, Division of Basic Sciences, National Cancer Institute, Bethesda, Maryland 20892-5055, the  Laboratory of Leukocyte Biology, Division of Basic Sciences, and the ^§ Intramural Research Support Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201

The E2F family of transcription factors regulates cell cycle progression, and deregulated expression of E2F-1 can lead to neoplastic transformation. In myeloid cells, introduction and expression of the Abelson leukemia virus causes growth factor independence. Here, the p120 v-Abl protein activates E2F-1-mediated transcription through a physical interaction with the E2F-1 transcription factor. BCR-Abl and c-Abl also stimulate E2F-1-mediated transcription. Our results suggest a new mechanism by which v-Abl leads to factor-independent myeloid cell proliferation: the activation of E2F-1-mediated transcription.

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