| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, October 25, 1996, and in revised form, January 17, 1997)
From the The ATX1 gene of Saccharomyces
cerevisiae was originally identified as a multi-copy suppressor
of oxidative damage in yeast lacking superoxide dismutase. We now
provide evidence that Atx1p helps deliver copper to the copper
requiring oxidase Fet3p involved in iron uptake. atx1
Volume 272, Number 14,
Issue of April 4, 1997
pp. 9215-9220
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
,
Division of Toxicological Sciences,
Department of Environmental Health Sciences, Johns Hopkins University
School of Public Health, Baltimore, Maryland 21205, the ¶ Cell
Biology and Metabolism Branch, NICHHD, National Institutes of Health,
Bethesda, Maryland 20892, and the § Department of Chemistry,
Northwestern University, Evanston, Illinois 60208-3113
null mutants are iron-deficient and are defective in the high affinity
uptake of iron. These defects due to ATX1 inactivation are
rescued by copper treatment, and the same has been reported for strains
lacking either the cell surface copper transporter, Ctr1p, or the
putative copper transporter in the secretory pathway, Ccc2p. Atx1p
localizes to the cytosol, and our studies indicate that it functions as
a carrier for copper that delivers the metal from the cell surface
Ctr1p to Ccc2p and then to Fet3p within the secretory pathway. The iron
deficiency of atx1 mutants is augmented by mutations in
END3 blocking endocytosis, suggesting that a parallel
pathway for intracellular copper trafficking is mediated by
endocytosis. As additional evidence for the role of Atx1p in iron
metabolism, we find that the gene is induced by the same iron-sensing
trans-activator, Aft1p, that regulates CCC2 and
FET3.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Itoh, H. W. Kim, O. Nakagawa, K. Ozumi, S. M. Lessner, H. Aoki, K. Akram, R. D. McKinney, M. Ushio-Fukai, and T. Fukai Novel Role of Antioxidant-1 (Atox1) as a Copper-dependent Transcription Factor Involved in Cell Proliferation J. Biol. Chem., April 4, 2008; 283(14): 9157 - 9167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ayala-Castro, A. Saini, and F. W. Outten Fe-S Cluster Assembly Pathways in Bacteria Microbiol. Mol. Biol. Rev., March 1, 2008; 72(1): 110 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-C. Chen, S. I. Hsieh, J. Kropat, and S. S. Merchant A Ferroxidase Encoded by FOX1 Contributes to Iron Assimilation under Conditions of Poor Iron Nutrition in Chlamydomonas Eukaryot. Cell, March 1, 2008; 7(3): 541 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P de Bie, P Muller, C Wijmenga, and L W J Klomp Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes J. Med. Genet., November 1, 2007; 44(11): 673 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Fei and X. Deng A Novel Fe Deficiency-Responsive Element (FeRE) Regulates the Expression of atx1 in Chlamydomonas reinharditii Plant Cell Physiol., October 1, 2007; 48(10): 1496 - 1503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Rees and D. J. Thiele Identification of a Vacuole-associated Metalloreductase and Its Role in Ctr2-mediated Intracellular Copper Mobilization J. Biol. Chem., July 27, 2007; 282(30): 21629 - 21638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-F. Lin, J. Yang, and B. P. Rosen ArsD Residues Cys12, Cys13, and Cys18 Form an As(III)-binding Site Required for Arsenic Metallochaperone Activity J. Biol. Chem., June 8, 2007; 282(23): 16783 - 16791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Cobine, F. Pierrel, M. L. Bestwick, and D. R. Winge Mitochondrial Matrix Copper Complex Used in Metallation of Cytochrome Oxidase and Superoxide Dismutase J. Biol. Chem., December 1, 2006; 281(48): 36552 - 36559. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-F. Lin, A. R. Walmsley, and B. P. Rosen An arsenic metallochaperone for an arsenic detoxification pump PNAS, October 17, 2006; 103(42): 15617 - 15622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Laliberte and S. Labbe Mechanisms of copper loading on the Schizosaccharomyces pombe copper amine oxidase 1 expressed in Saccharomyces cerevisiae. Microbiology, September 1, 2006; 152(Pt 9): 2819 - 2830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kaur, M. Pan, M. Meislin, M. T. Facciotti, R. El-Gewely, and N. S. Baliga A systems view of haloarchaeal strategies to withstand stress from transition metals Genome Res., July 1, 2006; 16(7): 841 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. T. Jensen and V. C. Culotta Activation of CuZn Superoxide Dismutases from Caenorhabditis elegans Does Not Require the Copper Chaperone CCS J. Biol. Chem., December 16, 2005; 280(50): 41373 - 41379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-C. Chu, W.-C. Lee, W.-Y. Guo, S.-M. Pan, L.-J. Chen, H.-m. Li, and T.-L. Jinn A Copper Chaperone for Superoxide Dismutase That Confers Three Types of Copper/Zinc Superoxide Dismutase Activity in Arabidopsis Plant Physiology, September 1, 2005; 139(1): 425 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Jeney, S. Itoh, M. Wendt, Q. Gradek, M. Ushio-Fukai, D. G. Harrison, and T. Fukai Role of Antioxidant-1 in Extracellular Superoxide Dismutase Function and Expression Circ. Res., April 15, 2005; 96(7): 723 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Abdel-Ghany, P. Muller-Moule, K. K. Niyogi, M. Pilon, and T. Shikanai Two P-Type ATPases Are Required for Copper Delivery in Arabidopsis thaliana Chloroplasts PLANT CELL, April 1, 2005; 17(4): 1233 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Rees, J. Lee, and D. J. Thiele Mobilization of Intracellular Copper Stores by the Ctr2 Vacuolar Copper Transporter J. Biol. Chem., December 24, 2004; 279(52): 54221 - 54229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Eriksson, J. L. Moseley, S. Tottey, J. A. del Campo, J. Quinn, Y. Kim, and S. Merchant Genetic Dissection of Nutritional Copper Signaling in Chlamydomonas Distinguishes Regulatory and Target Genes Genetics, October 1, 2004; 168(2): 795 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-C. Horng, P. A. Cobine, A. B. Maxfield, H. S. Carr, and D. R. Winge Specific Copper Transfer from the Cox17 Metallochaperone to Both Sco1 and Cox11 in the Assembly of Yeast Cytochrome c Oxidase J. Biol. Chem., August 20, 2004; 279(34): 35334 - 35340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Laliberte, L. J. Whitson, J. Beaudoin, S. P. Holloway, P. J. Hart, and S. Labbe The Schizosaccharomyces pombe Pccs Protein Functions in Both Copper Trafficking and Metal Detoxification Pathways J. Biol. Chem., July 2, 2004; 279(27): 28744 - 28755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Marvin, R. P. Mason, and A. M. Cashmore The CaCTR1 gene is required for high-affinity iron uptake and is transcriptionally controlled by a copper-sensing transactivator encoded by CaMAC1 Microbiology, July 1, 2004; 150(7): 2197 - 2208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Serrano, D. Bernal, E. Simon, and J. Arino Copper and Iron Are the Limiting Factors for Growth of the Yeast Saccharomyces cerevisiae in an Alkaline Environment J. Biol. Chem., May 7, 2004; 279(19): 19698 - 19704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Prohaska and A. A. Gybina Intracellular Copper Transport in Mammals J. Nutr., May 1, 2004; 134(5): 1003 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Cobine, L. D. Ojeda, K. M. Rigby, and D. R. Winge Yeast Contain a Non-proteinaceous Pool of Copper in the Mitochondrial Matrix J. Biol. Chem., April 2, 2004; 279(14): 14447 - 14455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shakoury-Elizeh, J. Tiedeman, J. Rashford, T. Ferea, J. Demeter, E. Garcia, R. Rolfes, P. O. Brown, D. Botstein, and C. C. Philpott Transcriptional Remodeling in Response to Iron Deprivation in Saccharomyces cerevisiae Mol. Biol. Cell, March 1, 2004; 15(3): 1233 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Maxfield, D. N. Heaton, and D. R. Winge Cox17 Is Functional When Tethered to the Mitochondrial Inner Membrane J. Biol. Chem., February 13, 2004; 279(7): 5072 - 5080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. De Freitas, J. H. Kim, H. Poynton, T. Su, H. Wintz, T. Fox, P. Holman, A. Loguinov, S. Keles, M. van der Laan, et al. Exploratory and Confirmatory Gene Expression Profiling of mac1{Delta} J. Biol. Chem., February 6, 2004; 279(6): 4450 - 4458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Rutherford and A. J. Bird Metal-Responsive Transcription Factors That Regulate Iron, Zinc, and Copper Homeostasis in Eukaryotic Cells Eukaryot. Cell, February 1, 2004; 3(1): 1 - 13. [Full Text] [PDF]
|
|
|
|
|
|
L. M. Trindade, B. M. Horvath, M. J.E. Bergervoet, and R. G.F. Visser Isolation of a Gene Encoding a Copper Chaperone for the Copper/Zinc Superoxide Dismutase and Characterization of Its Promoter in Potato Plant Physiology, October 1, 2003; 133(2): 618 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Protchenko and C. C. Philpott Regulation of Intracellular Heme Levels by HMX1, a Homologue of Heme Oxygenase, in Saccharomyces cerevisiae J. Biol. Chem., September 19, 2003; 278(38): 36582 - 36587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ralle, S. Lutsenko, and N. J. Blackburn X-ray Absorption Spectroscopy of the Copper Chaperone HAH1 Reveals a Linear Two-coordinate Cu(I) Center Capable of Adduct Formation with Exogenous Thiols and Phosphines J. Biol. Chem., June 13, 2003; 278(25): 23163 - 23170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Marvin, P. H. Williams, and A. M. Cashmore The Candida albicansCTR1 gene encodes a functional copper transporter Microbiology, June 1, 2003; 149(6): 1461 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shikanai, P. Muller-Moule, Y. Munekage, K. K. Niyogi, and M. Pilon PAA1, a P-Type ATPase of Arabidopsis, Functions in Copper Transport in Chloroplasts PLANT CELL, June 1, 2003; 15(6): 1333 - 1346. [Abstract] [Full Text]
|
|
|
|
|
|
D. Strausak, M. K. Howie, S. D. Firth, A. Schlicksupp, R. Pipkorn, G. Multhaup, and J. F. B. Mercer Kinetic Analysis of the Interaction of the Copper Chaperone Atox1 with the Metal Binding Sites of the Menkes Protein J. Biol. Chem., May 30, 2003; 278(23): 20821 - 20827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Finney and T. V. O'Halloran Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors Science, May 9, 2003; 300(5621): 931 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. El Meskini, V. C. Culotta, R. E. Mains, and B. A. Eipper Supplying Copper to the Cuproenzyme Peptidylglycine alpha -Amidating Monooxygenase J. Biol. Chem., March 28, 2003; 278(14): 12278 - 12284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Hamza, J. Prohaska, and J. D. Gitlin Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase PNAS, February 4, 2003; 100(3): 1215 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Uldschmid, M. Engel, R. Dombi, and K. Marbach Identification and functional expression of tahA, a filamentous fungal gene involved in copper trafficking to the secretory pathway in Trametes versicolor Microbiology, December 1, 2002; 148(12): 4049 - 4058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Bellemare, L. Shaner, K. A. Morano, J. Beaudoin, R. Langlois, and S. Labbe Ctr6, a Vacuolar Membrane Copper Transporter in Schizosaccharomyces pombe J. Biol. Chem., November 22, 2002; 277(48): 46676 - 46686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. La Fontaine, J. M. Quinn, S. S. Nakamoto, M. D. Page, V. Gohre, J. L. Moseley, J. Kropat, and S. Merchant Copper-Dependent Iron Assimilation Pathway in the Model Photosynthetic Eukaryote Chlamydomonas reinhardtii Eukaryot. Cell, October 1, 2002; 1(5): 736 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Walker, R. Tsivkovskii, and S. Lutsenko Metallochaperone Atox1 Transfers Copper to the NH2-terminal Domain of the Wilson's Disease Protein and Regulates Its Catalytic Activity J. Biol. Chem., July 26, 2002; 277(31): 27953 - 27959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Puig, J. Lee, M. Lau, and D. J. Thiele Biochemical and Genetic Analyses of Yeast and Human High Affinity Copper Transporters Suggest a Conserved Mechanism for Copper Uptake J. Biol. Chem., July 12, 2002; 277(29): 26021 - 26030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamaguchi-Iwai, R. Ueta, A. Fukunaka, and R. Sasaki Subcellular Localization of Aft1 Transcription Factor Responds to Iron Status in Saccharomyces cerevisiae J. Biol. Chem., May 17, 2002; 277(21): 18914 - 18918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Mandal, W. D. Cheung, and J. M. Arguello Characterization of a Thermophilic P-type Ag+/Cu+-ATPase from the Extremophile Archaeoglobus fulgidus J. Biol. Chem., February 22, 2002; 277(9): 7201 - 7208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tottey, S. A. M. Rondet, G. P. M. Borrelly, P. J. Robinson, P. R. Rich, and N. J. Robinson A Copper Metallochaperone for Photosynthesis and Respiration Reveals Metal-specific Targets, Interaction with an Importer, and Alternative Sites for Copper Acquisition J. Biol. Chem., February 8, 2002; 277(7): 5490 - 5497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. H. Lu and M. Solioz Copper-induced Proteolysis of the CopZ Copper Chaperone of Enterococcus hirae J. Biol. Chem., December 14, 2001; 276(51): 47822 - 47827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Hamza, A. Faisst, J. Prohaska, J. Chen, P. Gruss, and J. D. Gitlin The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis PNAS, June 5, 2001; 98(12): 6848 - 6852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Portnoy, X. F. Liu, and V. C. Culotta Saccharomyces cerevisiae Expresses Three Functionally Distinct Homologues of the Nramp Family of Metal Transporters Mol. Cell. Biol., November 1, 2000; 20(21): 7893 - 7902. [Abstract] [Full Text]
|
|
|
|
|
|
G. J. Colpas and R. P. Hausinger In Vivo and in Vitro Kinetics of Metal Transfer by the Klebsiella aerogenes Urease Nickel Metallochaperone, UreE J. Biol. Chem., April 6, 2000; 275(15): 10731 - 10737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-W. Yun, T. Ferea, J. Rashford, O. Ardon, P. O. Brown, D. Botstein, J. Kaplan, and C. C. Philpott Desferrioxamine-mediated Iron Uptake in Saccharomyces cerevisiae. EVIDENCE FOR TWO PATHWAYS OF IRON UPTAKE J. Biol. Chem., March 31, 2000; 275(14): 10709 - 10715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Woeste and J. J. Kieber A Strong Loss-of-Function Mutation in RAN1 Results in Constitutive Activation of the Ethylene Response Pathway as Well as a Rosette-Lethal Phenotype PLANT CELL, March 1, 2000; 12(3): 443 - 455. [Abstract] [Full Text]
|
|
|
|
|
|
G. S. Kelner, M. Lee, M. E. Clark, D. Maciejewski, D. McGrath, S. Rabizadeh, T. Lyons, D. Bredesen, P. Jenner, and R. A. Maki The Copper Transport Protein Atox1 Promotes Neuronal Survival J. Biol. Chem., January 7, 2000; 275(1): 580 - 584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Schmidt, M. Ramos-Gomez, and V. C. Culotta A Gain of Superoxide Dismutase (SOD) Activity Obtained with CCS, the Copper Metallochaperone for SOD1 J. Biol. Chem., December 24, 1999; 274(52): 36952 - 36956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Decottignies, G. Owsianik, and M. Ghislain Casein Kinase I-dependent Phosphorylation and Stability of the Yeast Multidrug Transporter Pdr5p J. Biol. Chem., December 24, 1999; 274(52): 37139 - 37146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Labbe, M. M. O. Pena, A. R. Fernandes, and D. J. Thiele A Copper-sensing Transcription Factor Regulates Iron Uptake Genes in Schizosaccharomyces pombe J. Biol. Chem., December 17, 1999; 274(51): 36252 - 36260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Hamza, M. Schaefer, L. W. J. Klomp, and J. D. Gitlin Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis PNAS, November 9, 1999; 96(23): 13363 - 13368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Larin, C. Mekios, K. Das, B. Ross, A.-S. Yang, and T. C. Gilliam Characterization of the Interaction between the Wilson and Menkes Disease Proteins and the Cytoplasmic Copper Chaperone, HAH1p J. Biol. Chem., October 1, 1999; 274(40): 28497 - 28504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Corson, J. Folmer, J. J. Strain, V. C. Culotta, and D. W. Cleveland Oxidative Stress and Iron Are Implicated in Fragmenting Vacuoles of Saccharomyces cerevisiae Lacking Cu,Zn-Superoxide Dismutase J. Biol. Chem., September 24, 1999; 274(39): 27590 - 27596. [Abstract] [Full Text] [PDF]
|
|
