HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Weitzmann, M. N. Articles by Usdin, K. Search for Related Content PubMed PubMed Citation Articles by Weitzmann, M. N. Articles by Usdin, K. Social Bookmarking                      What's this?

Volume 272, Number 14, Issue of April 4, 1997 pp. 9517-9523
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

---

DNA Secondary Structures and the Evolution of Hypervariable Tandem Arrays

(Received for publication, August 2, 1996, and in revised form, December 4, 1996)

From the Section on Genomic Structure and Function, Laboratory of Molecular and Cellular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0830

Tandem repeats are ubiquitous in nature and constitute a major source of genetic variability in populations. This variability is associated with a number of genetic disorders in humans including triplet expansion diseases such as Fragile X syndrome and Huntington's disease. The mechanism responsible for the variability/instability of these tandem arrays remains contentious. We show here that formation of secondary structures, in particular intrastrand tetraplexes, is an intrinsic property of some of the more unstable arrays. Tetraplexes block DNA polymerase progression and may promote instability of tandem arrays by increasing the likelihood of reiterative strand slippage. In the course of doing this work we have shown that some of these tetraplexes involve unusual base interactions. These interactions not only generate tetraplexes with novel properties but also lead us to conclude that the number of sequences that can form stable tetraplexes might be much larger than previously thought.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. G. Hershman, Q. Chen, J. Y. Lee, M. L. Kozak, P. Yue, L.-S. Wang, and F. B. Johnson Genomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae Nucleic Acids Res., January 17, 2008; 36(1): 144 - 156. [Abstract] [Full Text] [PDF]

				V. K. Yadav, J. K. Abraham, P. Mani, R. Kulshrestha, and S. Chowdhury QuadBase: genome-wide database of G4 DNA occurrence and conservation in human, chimpanzee, mouse and rat promoters and 146 microbes Nucleic Acids Res., January 11, 2008; 36(suppl_1): D381 - D385. [Abstract] [Full Text] [PDF]

				E. V. Mirkin and S. M. Mirkin Replication Fork Stalling at Natural Impediments Microbiol. Mol. Biol. Rev., March 1, 2007; 71(1): 13 - 35. [Abstract] [Full Text] [PDF]

				J. Eddy and N. Maizels Gene function correlates with potential for G4 DNA formation in the human genome Nucleic Acids Res., September 1, 2006; 34(14): 3887 - 3896. [Abstract] [Full Text] [PDF]

				P. Rawal, V. B. R. Kummarasetti, J. Ravindran, N. Kumar, K. Halder, R. Sharma, M. Mukerji, S. K. Das, and S. Chowdhury Genome-wide prediction of G4 DNA as regulatory motifs: Role in Escherichia coli global regulation. Genome Res., May 1, 2006; 16(5): 644 - 655. [Abstract] [Full Text] [PDF]

				A. Shelenkov, K. Skryabin, and E. Korotkov Search and Classification of Potential Minisatellite Sequences from Bacterial Genomes DNA Res, January 1, 2006; 13(3): 89 - 102. [Abstract] [Full Text] [PDF]

				N. E. Collins, J. Liebenberg, E. P. de Villiers, K. A. Brayton, E. Louw, A. Pretorius, F. E. Faber, H. van Heerden, A. Josemans, M. van Kleef, et al. The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number PNAS, January 18, 2005; 102(3): 838 - 843. [Abstract] [Full Text] [PDF]

				M. L. Duquette, P. Handa, J. A. Vincent, A. F. Taylor, and N. Maizels Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA Genes & Dev., July 1, 2004; 18(13): 1618 - 1629. [Abstract] [Full Text] [PDF]

				T. Lyons-Darden and M. D. Topal Abasic Sites Induce Triplet-repeat Expansion during DNA Replication in Vitro J. Biol. Chem., September 10, 1999; 274(37): 25975 - 25978. [Abstract] [Full Text] [PDF]

				M. N. Weitzmann, K. J. Woodford, and K. Usdin The Mouse Ms6-hm Hypervariable Microsatellite Forms a Hairpin and Two Unusual Tetraplexes J. Biol. Chem., November 13, 1998; 273(46): 30742 - 30749. [Abstract] [Full Text] [PDF]

				D. Mishmar, A. Rahat, S. W. Scherer, G. Nyakatura, B. Hinzmann, Y. Kohwi, Y. Mandel-Gutfroind, J. R. Lee, B. Drescher, D. E. Sas, et al. Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site PNAS, July 7, 1998; 95(14): 8141 - 8146. [Abstract] [Full Text] [PDF]

				R. M. Brosh Jr., A. Majumdar, S. Desai, I. D. Hickson, V. A. Bohr, and M. M. Seidman Unwinding of a DNA Triple Helix by the Werner and Bloom Syndrome Helicases J. Biol. Chem., January 26, 2001; 276(5): 3024 - 3030. [Abstract] [Full Text] [PDF]