| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, October 17, 1996, and in revised form, January 7, 1997)
From The Hormel Institute, University of Minnesota,
Austin, Minnesota 55912
Aspirin, along with its analgesic-antipyretic
uses, is now also being considered for prevention of cardiovascular
disease, cancer, and treatment of human immunodeficiency virus
infection. Although many of aspirin's pharmacological actions are
related to its ability to inhibit prostaglandin biosynthesis, some of its beneficial therapeutic effects are not completely understood. Transcription factor activator protein 1 (AP-1) is critical for the
induction of neoplastic transformation and induction of multiple genes
involved in inflammation and infection. We have used the JB6 mouse
epidermal cell lines, a system that has been used extensively as an
in vitro model for the study of tumor promotion and
anti-tumor promotion, to study the anti-carcinogenesis effect of
aspirin at the molecular level. Aspirin and aspirin-like salicylates
inhibited the activation of AP-1 in the same dose range as seen for the inhibition of tumor promoter-induced transformation. The inhibition of
AP-1 and tumor promoter-induced transformation in JB6 cells occurs
through a prostaglandin independent- and an Erk1- or Erk2-independent pathway. The mechanism of AP-1 and transformation inhibition in this
cell culture model may involve the elevation of H+
concentration. The inhibition effects on the activation of AP-1 activity by aspirin and aspirin-like salicylates may further explain the anti-carcinogenesis mechanism of action of these drugs.
Volume 272, Number 15,
Issue of April 11, 1997
pp. 9962-9970
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Oshima, H. Miwa, and T. Joh Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7 Am J Physiol Cell Physiol, September 1, 2008; 295(3): C800 - C806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Kang, K. W. Lee, E. A. Rogozin, Y.-Y. Cho, Y.-S. Heo, A. M. Bode, H. J. Lee, and Z. Dong Equol, a Metabolite of the Soybean Isoflavone Daidzein, Inhibits Neoplastic Cell Transformation by Targeting the MEK/ERK/p90RSK/Activator Protein-1 Pathway J. Biol. Chem., November 9, 2007; 282(45): 32856 - 32866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Wang, K. S. Lewers, L. Bowman, and M. Ding Antioxidant Activities and Anticancer Cell Proliferation Properties of Wild Strawberries J. Amer. Soc. Hort. Sci., September 1, 2007; 132(5): 647 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Furst, S. B. Blumenthal, A. K. Kiemer, S. Zahler, and A. M. Vollmar Nuclear Factor-{kappa}B-Independent Anti-Inflammatory Action of Salicylate in Human Endothelial Cells: Induction of Heme Oxygenase-1 by the c-Jun N-Terminal Kinase/Activator Protein-1 Pathway J. Pharmacol. Exp. Ther., July 1, 2006; 318(1): 389 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. di Palma, G. Matarese, V. Leone, T. Di Matola, F. Acquaviva, A. M. Acquaviva, and P. Ricchi Aspirin reduces the outcome of anticancer therapy in Meth A-bearing mice through activation of AKT-glycogen synthase kinase signaling Mol. Cancer Ther., May 1, 2006; 5(5): 1318 - 1324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Cieslik, Y. Zhu, M. Shtivelband, and K. K. Wu Inhibition of p90 Ribosomal S6 Kinase-mediated CCAAT/Enhancer-binding Protein {beta} Activation and Cyclooxygenase-2 Expression by Salicylate J. Biol. Chem., May 6, 2005; 280(18): 18411 - 18417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Baek, J.-S. Kim, F. R. Jackson, T. E. Eling, M. F. McEntee, and S.-H. Lee Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells Carcinogenesis, December 1, 2004; 25(12): 2425 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Aceves, A. Duenas, C. Gomez, E. San Vicente, M. S. Crespo, and C. Garcia-Rodriguez A New Pharmacological Effect of Salicylates: Inhibition of NFAT-Dependent Transcription J. Immunol., November 1, 2004; 173(9): 5721 - 5729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ma, J. Wang, and J. Luo Exposure to Asphalt Fumes Activates Activator Protein-1 through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Mouse Epidermal Cells J. Biol. Chem., November 7, 2003; 278(45): 44265 - 44272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ricchi, A. D. Palma, T. D. Matola, A. Apicella, R. Fortunato, R. Zarrilli, and A. M. Acquaviva Aspirin Protects Caco-2 Cells from Apoptosis after Serum Deprivation through the Activation of a Phosphatidylinositol 3-Kinase/AKT/p21Cip/WAF1Pathway Mol. Pharmacol., August 1, 2003; 64(2): 407 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. He, Y.-Y. Cho, G. Liu, W.-Y. Ma, A. M. Bode, and Z. Dong p38 Mitogen-activated Protein Kinase Regulation of JB6 Cl41 Cell Transformation Promoted by Epidermal Growth Factor J. Biol. Chem., July 11, 2003; 278(29): 26435 - 26442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Bode and Z. Dong Mitogen-Activated Protein Kinase Activation in UV-Induced Signal Transduction Sci. Signal., January 28, 2003; 2003(167): re2 - re2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. B. Bair III, N. Hart, J. Einspahr, G. Liu, Z. Dong, D. Alberts, and G. T. Bowden Inhibitory Effects of Sodium Salicylate and Acetylsalicylic Acid on UVB-induced Mouse Skin Carcinogenesis Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1645 - 1652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Baek, L. C. Wilson, C.-H. Lee, and T. E. Eling Dual Function of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Inhibition of Cyclooxygenase and Induction of NSAID-Activated Gene J. Pharmacol. Exp. Ther., June 1, 2002; 301(3): 1126 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Dong and J. L. Cmarik Harvesting Cells Under Anchorage-Independent Cell Transformation Conditions for Biochemical Analyses Sci. Signal., April 30, 2002; 2002(130): pl7 - pl7. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. TOSETTI, N. FERRARI, S. DE FLORA, and A. ALBINI Angioprevention': angiogenesis is a common and key target for cancer chemopreventive agents FASEB J, January 1, 2002; 16(1): 2 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. TEGEDER, J. PFEILSCHIFTER, and G. GEISSLINGER Cyclooxygenase-independent actions of cyclooxygenase inhibitors FASEB J, October 1, 2001; 15(12): 2057 - 2072. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-L. Liao, Y.-L. Lin, B.-C. Wu, C.-H. Tsao, M.-C. Wang, C.-I Liu, Y.-L. Huang, J.-H. Chen, J.-P. Wang, and L.-K. Chen Salicylates Inhibit Flavivirus Replication Independently of Blocking Nuclear Factor Kappa B Activation J. Virol., September 1, 2001; 75(17): 7828 - 7839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Liu, A. Bode, W.-Y. Ma, S. Sang, C.-T. Ho, and Z. Dong Two Novel Glycosides from the Fruits of Morinda Citrifolia (Noni) Inhibit AP-1 Transactivation and Cell Transformation in the Mouse Epidermal JB6 Cell Line Cancer Res., August 1, 2001; 61(15): 5749 - 5756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yu, V. Hebbar, D. W. Kim, S. Mandlekar, J. M. Pezzuto, and A.-N. T. Kong Resveratrol Inhibits Phorbol Ester and UV-Induced Activator Protein 1 Activation by Interfering with Mitogen-Activated Protein Kinase Pathways Mol. Pharmacol., July 1, 2001; 60(1): 217 - 224. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Liu, D. M. Bibus, A. M. Bode, W.-Y. Ma, R. T. Holman, and Z. Dong Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells PNAS, June 19, 2001; 98(13): 7510 - 7515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Krishnan, M. T. Ruffin, D. Normolle, I. Shureiqi, K. Burney, J. Bailey, M. Peters-Golden, C. L. Rock, C. R. Boland, and D. E. Brenner Colonic Mucosal Prostaglandin E2 and Cyclooxygenase Expression before and after Low Aspirin Doses in Subjects at High Risk or at Normal Risk for Colorectal Cancer Cancer Epidemiol. Biomarkers Prev., May 1, 2001; 10(5): 447 - 453. [Abstract] [Full Text]
|
|
|
|
|
|
G. Liu, N. Chen, A. Kaji, A. M. Bode, C. A. Ryan, and Z. Dong Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells PNAS, April 25, 2001; (2001) 101116298. [Abstract] [Full Text]
|
|
|
|
|
|
C. M. Bradbury, J. E. Locke, S. J. Wei, L. M. Rene, S. Karimpour, C. Hunt, D. R. Spitz, and D. Gius Increased Activator Protein 1 Activity as Well as Resistance to Heat-induced Radiosensitization, Hydrogen Peroxide, and Cisplatin Are Inhibited by Indomethacin in Oxidative Stress-resistant Cells Cancer Res., April 1, 2001; 61(8): 3486 - 3492. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Cianferoni, J. T. Schroeder, J. Kim, J. W. Schmidt, L. M. Lichtenstein, S. N. Georas, and V. Casolaro Selective inhibition of interleukin-4 gene expression in human T cells by aspirin Blood, March 15, 2001; 97(6): 1742 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Murakami, K. Kawabata, T. Koshiba, G. Gao, Y. Nakamura, K. Koshimizu, and H. Ohigashi Nitric Oxide Synthase Is Induced in Tumor Promoter-sensitive, but not Tumor Promoter-resistant, JB6 Mouse Epidermal Cells Cocultured with Interferon- {{gamma}}-stimulated RAW 264.7 Cells: The Role of Tumor Necrosis Factor-{{alpha}} Cancer Res., November 1, 2000; 60(22): 6326 - 6331. [Abstract] [Full Text]
|
|
|
|
|
|
M. Li, R. Lotan, B. Levin, E. Tahara, S. M. Lippman, and X.-C. Xu Aspirin Induction of Apoptosis in Esophageal Cancer: A Potential for Chemoprevention Cancer Epidemiol. Biomarkers Prev., June 1, 2000; 9(6): 545 - 549. [Abstract] [Full Text]
|
|
|
|
|
|
R. ZEIDLER, M. CSANADY, O. GIRES, S. LANG, B. SCHMITT, and B. WOLLENBERG Tumor cell-derived prostaglandin E2 inhibits monocyte function by interfering with CCR5 and Mac-1 FASEB J, April 1, 2000; 14(5): 661 - 668. [Abstract] [Full Text]
|
|
|
|
|
|
A. Kagawa, H. Azuma, M. Akaike, Y. Kanagawa, and T. Matsumoto Aspirin Reduces Apolipoprotein(a) (Apo(a)) Production in Human Hepatocytes by Suppression of Apo(a) Gene Transcription J. Biol. Chem., November 26, 1999; 274(48): 34111 - 34115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kramer-Stickland, A. Edmonds, W. B. Bair III, and G.T. Bowden Inhibitory effects of deferoxamine on UVB-induced AP-1 transactivation Carcinogenesis, November 1, 1999; 20(11): 2137 - 2142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ding, X. Shi, Z. Dong, F. Chen, Y. Lu, V. Castranova, and V. Vallyathan Freshly Fractured Crystalline Silica Induces Activator Protein-1 Activation through ERKs and p38 MAPK J. Biol. Chem., October 22, 1999; 274(43): 30611 - 30616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Shiff and B. Rigas The Role of Cyclooxygenase Inhibition in the Antineoplastic Effects of Nonsteroidal Antiinflammatory Drugs (NSAIDs) J. Exp. Med., August 16, 1999; 190(4): 445 - 450. [Full Text] [PDF]
|
|
|
|
|
|
N. Chen, W.-y. Ma, C. Huang, and Z. Dong Translocation of Protein Kinase Cepsilon and Protein Kinase Cdelta to Membrane Is Required for Ultraviolet B-induced Activation of Mitogen-activated Protein Kinases and Apoptosis J. Biol. Chem., May 28, 1999; 274(22): 15389 - 15394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Huang, W.-Y. Ma, J. Li, A. Goranson, and Z. Dong Requirement of Erk, but Not JNK, for Arsenite-induced Cell Transformation J. Biol. Chem., May 21, 1999; 274(21): 14595 - 14601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-M. Xu, L. Sansores-Garcia, X.-M. Chen, N. Matijevic-Aleksic, M. Du, and K. K. Wu Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate PNAS, April 27, 1999; 96(9): 5292 - 5297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ding, J.-J. Li, S. S. Leonard, J.-P. Ye, X. Shi, N. H. Colburn, V. Castranova, and V. Vallyathan Vanadate-induced activation of activator protein-1: role of reactive oxygen species Carcinogenesis, April 1, 1999; 20(4): 663 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ding, Z. Dong, F. Chen, D. Pack, W.-Y. Ma, J. Ye, X. Shi, V. Castranova, and V. Vallyathan Asbestos Induces Activator Protein-1 Transactivation in Transgenic Mice Cancer Res., April 1, 1999; 59(8): 1884 - 1889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Klampfer, J. Cammenga, H.-G. Wisniewski, and S. D. Nimer Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines Blood, April 1, 1999; 93(7): 2386 - 2394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Rosenberger, J. S. Finch, A. Gupta, and G. T. Bowden Extracellular Signal-regulated Kinase 1/2-mediated Phosphorylation of JunD and FosB Is Required for Okadaic Acid-induced Activator Protein 1 Activation J. Biol. Chem., January 8, 1999; 274(2): 1124 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Pillinger, C. Capodici, P. Rosenthal, N. Kheterpal, S. Hanft, M. R. Philips, and G. Weissmann Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion PNAS, November 24, 1998; 95(24): 14540 - 14545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Bellosillo, M. Pique, M. Barragan, E. Castano, N. Villamor, D. Colomer, E. Montserrat, G. Pons, and J. Gil Aspirin and Salicylate Induce Apoptosis and Activation of Caspases in B-Cell Chronic Lymphocytic Leukemia Cells Blood, August 15, 1998; 92(4): 1406 - 1414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Huang, W.-Y. Ma, M. R. Young, N. Colburn, and Z. Dong Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells PNAS, January 6, 1998; 95(1): 156 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Huang, W.-Y. Ma, C. A. Ryan, and Z. Dong Proteinase inhibitors I and II from potatoes specifically block UV-induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and P38 kinase PNAS, October 28, 1997; 94(22): 11957 - 11962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Huang, W.-Y. Ma, D. Hanenberger, M. P. Cleary, G. T. Bowden, and Z. Dong Inhibition of Ultraviolet B-induced Activator Protein-1 (AP-1) Activity by Aspirin in AP-1-Luciferase Transgenic Mice J. Biol. Chem., October 17, 1997; 272(42): 26325 - 26331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Paccani, M. Boncristiano, C. Ulivieri, M. M. D'Elios, G. Del Prete, and C. T. Baldari Nonsteroidal Anti-inflammatory Drugs Suppress T-cell Activation by Inhibiting p38 MAPK Induction J. Biol. Chem., January 4, 2002; 277(2): 1509 - 1513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Liu, N. Chen, A. Kaji, A. M. Bode, C. A. Ryan, and Z. Dong Proteinase inhibitors I and II from potatoes block UVB-induced AP-1 activity by regulating the AP-1 protein compositional patterns in JB6 cells PNAS, May 8, 2001; 98(10): 5786 - 5791. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
