| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, October 23, 1996, and in revised form, March 10, 1997)
From the Intramural Research Support Program and
§ Clinical Immunology Services, Monocyte chemotactic protein (MCP)-2 is a member
of the C-C chemokine subfamily, which shares more than 60% sequence
homology with MCP-1 and MCP-3 and about 30% homology with macrophage
inflammatory protein (MIP)-1
Volume 272, Number 18,
Issue of May 2, 1997
pp. 11682-11685
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
,
,
,
Laboratory of Molecular Immunoregulation,
, regulated on activation of normal T
cell expressed (RANTES), and MIP-1
. Despite this considerable
sequence homology to other C-C chemokines, MCP-2 appears to have unique
functional properties in comparison with other C-C chemokines such as
MCP-1 and MCP-3. Although evidence obtained from studies on leukocytes suggested that MCP-2 may share the receptors with these C-C chemokines, the actual functional receptors for MCP-2 have not yet been identified. In this study, by using radioiodinated MCP-2, we identified high affinity binding sites for MCP-2 on human peripheral blood monocytes. The MCP-2 binding was competed for by MCP-1 and MCP-3, but less well by
MIP-1 or RANTES. In experiments using cells transfected with C-C
chemokine receptors, 125I-MCP-2 bound to human
embryonic kidney 293 cells transfected with CCR1 or CCR2B, known to
also bind MIP-1/RANTES and MCP-1, respectively, but both shared by
MCP-3. The binding of 125I-MCP-2 to these
receptor-transfected cells was displaced completely by chemokines that
bind to these receptors. Both CCR1- and CCR2B-transfected 293 cells
showed significant migration in response to MCP-2, in addition to
responding to other specific chemokines. These results clearly
demonstrate that MCP-2, unlike MCP-1, uses both CCR1 as well as CCR2B
as its functional receptors, and this accounts for the unique
activities of MCP-2.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K. E. Inouye, H. Shi, J. K. Howard, C. H. Daly, G. M. Lord, B. J. Rollins, and J. S. Flier Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue Diabetes, September 1, 2007; 56(9): 2242 - 2250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tone, K. Shikata, D. Ogawa, S. Sasaki, R. Nagase, M. Sasaki, K. Yozai, H. Kataoka Usui, S. Okada, J. Wada, et al. Changes of gene expression profiles in macrophages stimulated by angiotensin II -- Angiotensin II induces MCP-2 through AT1-receptor Journal of Renin-Angiotensin-Aldosterone System, March 1, 2007; 8(1): 45 - 50. [Abstract] [PDF]
|
|
|
|
 |
|
 S. E. Crown, Y. Yu, M. D. Sweeney, J. A. Leary, and T. M. Handel Heterodimerization of CCR2 Chemokines and Regulation by Glycosaminoglycan Binding J. Biol. Chem., September 1, 2006; 281(35): 25438 - 25446. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gupta, S. Schulz-Maronde, C. Kutzleb, R. Richter, W.-G. Forssmann, A. Kapp, U. Forssmann, and J. Elsner Cloning, expression, and functional characterization of cynomolgus monkey (Macaca fascicularis) CC chemokine receptor 1 J. Leukoc. Biol., November 1, 2005; 78(5): 1175 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. L. de Mendonca, P. C. A. da Fonseca, R. M. Phillips, J. W. Saldanha, T. J. Williams, and J. E. Pease Site-directed Mutagenesis of CC Chemokine Receptor 1 Reveals the Mechanism of Action of UCB 35625, a Small Molecule Chemokine Receptor Antagonist J. Biol. Chem., February 11, 2005; 280(6): 4808 - 4816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gouwy, S. Struyf, J. Catusse, P. Proost, and J. Van Damme Synergy between proinflammatory ligands of G protein-coupled receptors in neutrophil activation and migration J. Leukoc. Biol., July 1, 2004; 76(1): 185 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Peterson, J. S. Errett, T. Wei, D. E. Dimcheff, R. Ransohoff, W. A. Kuziel, L. Evans, and B. Chesebro MCP-1 and CCR2 Contribute to Non-Lymphocyte-Mediated Brain Disease Induced by Fr98 Polytropic Retrovirus Infection in Mice: Role for Astrocytes in Retroviral Neuropathogenesis J. Virol., June 15, 2004; 78(12): 6449 - 6458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Christensen, M. Du, B. Moore, S. Morris, G. B. Toews, and R. Paine III Expression and functional implications of CCR2 expression on murine alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L68 - L72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Sato, T. Higuchi, S. Yoshioka, K. Tatsumi, H. Fujiwara, and S. Fujii Trophoblasts acquire a chemokine receptor, CCR1, as they differentiate towards invasive phenotype Development, November 15, 2003; 130(22): 5519 - 5532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakano, K. Tadagaki, Y. Isegawa, M. M. Aye, P. Zou, and K. Yamanishi Human Herpesvirus 7 Open Reading Frame U12 Encodes a Functional {beta}-Chemokine Receptor J. Virol., July 15, 2003; 77(14): 8108 - 8115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Luttichau, I. Clark-Lewis, P. O. Jensen, C. Moser, J. Gerstoft, and T. W. Schwartz A Highly Selective CCR2 Chemokine Agonist Encoded by Human Herpesvirus 6 J. Biol. Chem., March 21, 2003; 278(13): 10928 - 10933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Martinelli, I. Sabroe, G. LaRosa, T. J. Williams, and J. E. Pease The CC Chemokine Eotaxin (CCL11) Is a Partial Agonist of CC Chemokine Receptor 2b J. Biol. Chem., November 9, 2001; 276(46): 42957 - 42964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-W. Hong, J. J. Liu, J.-S. Lee, R. R. Mohan, R. R. Mohan, D. J. Woods, Y.-G. He, and S. E. Wilson Proinflammatory Chemokine Induction in Keratocytes and Inflammatory Cell Infiltration into the Cornea Invest. Ophthalmol. Vis. Sci., November 1, 2001; 42(12): 2795 - 2803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. B. Moore, R. Paine III, P. J. Christensen, T. A. Moore, S. Sitterding, R. Ngan, C. A. Wilke, W. A. Kuziel, and G. B. Toews Protection from Pulmonary Fibrosis in the Absence of CCR2 Signaling J. Immunol., October 15, 2001; 167(8): 4368 - 4377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. SEGERER, Y. CUI, K. L. HUDKINS, T. GOODPASTER, F. EITNER, M. MACK, D. SCHLÖNDORFF, and C. E. ALPERS Expression of the Chemokine Monocyte Chemoattractant Protein-1 and Its Receptor Chemokine Receptor 2 in Human Crescentic Glomerulonephritis J. Am. Soc. Nephrol., December 1, 2000; 11(12): 2231 - 2242. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. MacLean, G. T. De Sanctis, K. G. Ackerman, J. M. Drazen, A. Sauty, E. DeHaan, F. H. Y. Green, I. F. Charo, and A. D. Luster CC Chemokine Receptor-2 Is Not Essential for the Development of Antigen-Induced Pulmonary Eosinophilia and Airway Hyperresponsiveness J. Immunol., December 1, 2000; 165(11): 6568 - 6575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. M. Z. Howard, H. F. Dong, A.-K. Shirakawa, and J. J. Oppenheim LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8 Blood, August 1, 2000; 96(3): 840 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Murdoch and A. Finn Chemokine receptors and their role in inflammation and infectious diseases Blood, May 15, 2000; 95(10): 3032 - 3043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Schweickart, A. Epp, C. J. Raport, and P. W. Gray CCR11 Is a Functional Receptor for the Monocyte Chemoattractant Protein Family of Chemokines J. Biol. Chem., March 24, 2000; 275(13): 9550 - 9556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors Pharmacol. Rev., March 1, 2000; 52(1): 145 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Le, W. Gong, B. Li, N. M. Dunlop, W. Shen, S. B. Su, R. D. Ye, and J. M. Wang Utilization of Two Seven-Transmembrane, G Protein-Coupled Receptors, Formyl Peptide Receptor-Like 1 and Formyl Peptide Receptor, by the Synthetic Hexapeptide WKYMVm for Human Phagocyte Activation J. Immunol., December 15, 1999; 163(12): 6777 - 6784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Su, W.-h. Gong, J.-L. Gao, W.-P. Shen, M. C. Grimm, X. Deng, P. M. Murphy, J. J. Oppenheim, and J. M. Wang T20/DP178, an Ectodomain Peptide of Human Immunodeficiency Virus Type 1 gp41, Is an Activator of Human Phagocyte N-Formyl Peptide Receptor Blood, June 1, 1999; 93(11): 3885 - 3892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Su, J.-l. Gao, W.-h. Gong, N. M. Dunlop, P. M. Murphy, J. J. Oppenheim, and J. M. Wang T21/DP107, A Synthetic Leucine Zipper-Like Domain of the HIV-1 Envelope gp41, Attracts and Activates Human Phagocytes by Using G-Protein-Coupled Formyl Peptide Receptors J. Immunol., May 15, 1999; 162(10): 5924 - 5930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Su, W. Gong, J.-L. Gao, W. Shen, P. M. Murphy, J. J. Oppenheim, and J. M. Wang A Seven-transmembrane, G Protein-coupled Receptor, FPRL1, Mediates the Chemotactic Activity of Serum Amyloid A for Human Phagocytic Cells J. Exp. Med., January 18, 1999; 189(2): 395 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Wang, H. Ueda, O. M. Z. Howard, M. C. Grimm, O. Chertov, X. Gong, W. Gong, J. H. Resau, C. C. Broder, G. Evans, et al. HIV-1 Envelope gp120 Inhibits the Monocyte Response to Chemokines Through CD4 Signal-Dependent Chemokine Receptor Down-Regulation J. Immunol., October 15, 1998; 161(8): 4309 - 4317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Turner, J. Domin, M. D. Waterfield, S. G. Ward, and J. Westwick The CC Chemokine Monocyte Chemotactic Peptide-1 Activates both the Class I p85/p110 Phosphatidylinositol 3-Kinase and the Class II PI3K-C2alpha J. Biol. Chem., October 2, 1998; 273(40): 25987 - 25995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-L. Tsou, R. P. Gladue, L. A. Carroll, T. Paradis, J. G. Boyd, R. T. Nelson, K. Neote, and I. F. Charo Identification of C-C Chemokine Receptor 1 (CCR1) as the Monocyte Hemofiltrate C-C Chemokine (HCC)-1 Receptor J. Exp. Med., August 3, 1998; 188(3): 603 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Proost, S. Struyf, M. Couvreur, J.-P. Lenaerts, R. Conings, P. Menten, P. Verhaert, A. Wuyts, and J. V. Damme Posttranslational Modifications Affect the Activity of the Human Monocyte Chemotactic Proteins MCP-1 and MCP-2: Identification of MCP-2(6-76) as a Natural Chemokine Inhibitor J. Immunol., April 15, 1998; 160(8): 4034 - 4041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Gong, O. M. Z. Howard, J. A. Turpin, M. C. Grimm, H. Ueda, P. W. Gray, C. J. Raport, J. J. Oppenheim, and J. M. Wang Monocyte Chemotactic Protein-2 Activates CCR5 and Blocks CD4/CCR5-mediated HIV-1 Entry/Replication J. Biol. Chem., February 20, 1998; 273(8): 4289 - 4292. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
