JBC Ideal method for primary cell transfection

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Volume 272, Number 18, Issue of May 2, 1997 pp. 11916-11923
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

A Novel Drosophila Receptor Tyrosine Kinase Expressed Specifically in the Nervous System
UNIQUE STRUCTURAL FEATURES AND IMPLICATION IN DEVELOPMENTAL SIGNALING

(Received for publication, July 23, 1996, and in revised form, February 6, 1997)

Isao Oishi Dagger , Shin Sugiyama § , Zhao-Jun Liu Dagger , Hirohei Yamamura Dagger , Yasuyoshi Nishida § and Yasuhiro Minami Dagger

From the Dagger  Department of Biochemistry, Kobe University School of Medicine, 7-5-1, Kusunoki-chou, Chuo-Ku, Kobe 650, Japan and § Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-01, Japan

We report the identification and characterization of Dnrk (Drosophila neurospecific receptor kinase), a Drosophila gene encoding a putative receptor tyrosine kinase (RTK) highly related to the Trk and Ror families of RTKs. During Drosophila embryogenesis, the Dnrk gene is expressed specifically in the developing nervous system. The Dnrk protein possesses two conserved cysteine-containing domains and a kringle domain within its extracellular domain, resembling those observed in Ror family RTKs (Ror1, Ror2, and a Drosophila Ror, Dror). This protein contains the catalytic tyrosine kinase (TK) domain with two putative ATP-binding motifs, resembling those observed in another Drosophila RTK (Dtrk) that mediates homophilic cell adhesion. The TK domain of Dnrk, expressed in bacteria or mammalian cells, exhibits apparent autophosphorylation activities in vitro. The TK domain lacking the distal ATP-binding motif also exhibits autophosphorylation activity, yet to a lesser extent. In addition to its TK activity, there are several putative tyrosine-containing motifs that upon phosphorylation may interact with Src homology 2 regions of other signaling molecules. Collectively, these results suggest that Dnrk may play an important role in neural development during Drosophila embryogenesis.


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