JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Franchimont, N.
Right arrow Articles by Canalis, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Franchimont, N.
Right arrow Articles by Canalis, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Volume 272, Number 18, Issue of May 2, 1997 pp. 12144-12150
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

Interleukin-6 and Its Soluble Receptor Cause a Marked Induction of Collagenase 3 Expression in Rat Osteoblast Cultures

(Received for publication, September 13, 1996, and in revised form, February 24, 1997)

Nathalie Franchimont , Sheila Rydziel , Anne M. Delany and Ernesto Canalis

From the Departments of Research and Medicine, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105 and The University of Connecticut School of Medicine, Farmington, Connecticut 06030

Interleukin-6 (IL-6), a cytokine produced by skeletal cells, increases bone resorption, but its effects on collagenase expression are unknown. We tested the effects of IL-6 and its soluble receptor on collagenase 3 expression in osteoblast-enriched cells from fetal rat calvariae (Ob cells). IL-6 caused a small increase in collagenase mRNA levels, but in the presence of IL-6-soluble receptor (IL-6sR), IL-6 caused a marked increase in collagenase transcripts after 2-24 h. In addition, IL-6sR increased collagenase mRNA when tested alone. IL-6 and IL-6sR increased immunoreactive collagenase levels. Cycloheximide and indomethacin did not prevent the effect of IL-6 and IL-6sR on collagenase mRNA levels. IL-6 and IL-6sR did not alter the decay of collagenase mRNA in transcriptionally arrested Ob cells and increased the levels of collagenase heterogeneous nuclear RNA and the rate of collagenase gene transcription in Ob cells. IL-6 and IL-6sR increased collagenase 3 mRNA in MC3T3 cells but only modestly in skin fibroblasts. IL-6 and IL-6sR enhanced the expression of tissue inhibitor of metalloproteinases 1. In conclusion, IL-6, in the presence of IL-6sR, increases collagenase 3 synthesis in osteoblasts by transcriptional mechanisms. This effect may contribute to the action of IL-6 on bone matrix degradation and bone resorption.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
S. Rose-John, J. Scheller, G. Elson, and S. A. Jones
Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer
J. Leukoc. Biol., August 1, 2006; 80(2): 227 - 236.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Pischon, L. M. Darbois, A. H. Palamakumbura, E. Kessler, and P. C. Trackman
Regulation of Collagen Deposition and Lysyl Oxidase by Tumor Necrosis Factor-{alpha} in Osteoblasts
J. Biol. Chem., July 16, 2004; 279(29): 30060 - 30065.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. A. Nowell, P. J. Richards, S. Horiuchi, N. Yamamoto, S. Rose-John, N. Topley, A. S. Williams, and S. A. Jones
Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130
J. Immunol., September 15, 2003; 171(6): 3202 - 3209.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Di Girolamo, R. K. Kumar, M. T. Coroneo, and D. Wakefield
UVB-Mediated Induction of Interleukin-6 and -8 in Pterygia and Cultured Human Pterygium Epithelial Cells
Invest. Ophthalmol. Vis. Sci., November 1, 2002; 43(11): 3430 - 3437.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
M. Tsubota, Y. Sasano, I. Takahashi, M. Kagayama, and H. Shimauchi
Expression of MMP-8 and MMP-13 mRNAs in Rat Periodontium during Tooth Eruption
J. Dent. Res., October 1, 2002; 81(10): 673 - 678.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
Y. Sasano, J.-X. Zhu, M. Tsubota, I. Takahashi, K. Onodera, I. Mizoguchi, and M. Kagayama
Gene Expression of MMP8 and MMP13 During Embryonic Development of Bone and Cartilage in the Rat Mandible and Hind Limb
J. Histochem. Cytochem., March 1, 2002; 50(3): 325 - 332.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Onodera, J. Nishihira, K. Iwabuchi, Y. Koyama, K. Yoshida, S. Tanaka, and A. Minami
Macrophage Migration Inhibitory Factor Up-regulates Matrix Metalloproteinase-9 and -13 in Rat Osteoblasts. RELEVANCE TO INTRACELLULAR SIGNALING PATHWAYS
J. Biol. Chem., March 1, 2002; 277(10): 7865 - 7874.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Burger, M. Benicke, A. Deten, and H.-G. Zimmer
Catecholamines stimulate interleukin-6 synthesis in rat cardiac fibroblasts
Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H14 - H21.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. A. JONES, S. HORIUCHI, N. TOPLEY, N. YAMAMOTO, and G. M. FULLER
The soluble interleukin 6 receptor: mechanisms of production and implications in disease
FASEB J, January 1, 2001; 15(1): 43 - 58.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. Varghese, S. Rydziel, and E. Canalis
Basic Fibroblast Growth Factor Stimulates Collagenase-3 Promoter Activity in Osteoblasts through an Activator Protein-1-Binding Site
Endocrinology, June 1, 2000; 141(6): 2185 - 2191.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. A. Solis-Herruzo, R. A. Rippe, L. W. Schrum, P. de la Torre, I. Garcia, J. J. Jeffrey, T. Munoz-Yague, and D. A. Brenner
Interleukin-6 Increases Rat Metalloproteinase-13 Gene Expression through Stimulation of Activator Protein 1 Transcription Factor in Cultured Fibroblasts
J. Biol. Chem., October 22, 1999; 274(43): 30919 - 30926.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. C. Pereira, V. Jorgetti, and E. Canalis
Triiodothyronine induces collagenase-3 and gelatinase B expression in murine osteoblasts
Am J Physiol Endocrinol Metab, September 1, 1999; 277(3): E496 - E504.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. J. G. Jimenez, M. Balbin, J. M. Lopez, J. Alvarez, T. Komori, and C. Lopez-Otin
Collagenase 3 Is a Target of Cbfa1, a Transcription Factor of the runt Gene Family Involved in Bone Formation
Mol. Cell. Biol., June 1, 1999; 19(6): 4431 - 4442.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Inoue, C. Shih, D. L. Galson, S. R. Goldring, W. C. Horne, and R. Baron
Calcitonin-Dependent Down-Regulation of the Mouse C1a Calcitonin Receptor in Cells of the Osteoclast Lineage Involves a Transcriptional Mechanism
Endocrinology, March 1, 1999; 140(3): 1060 - 1068.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. Varghese, K. Yu, and E. Canalis
Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts
Am J Physiol Endocrinol Metab, March 1, 1999; 276(3): E465 - E471.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. E. Choi
Cloning and characterization of a naturally occurring soluble form of TGF-beta type I receptor
Am J Physiol Renal Physiol, January 1, 1999; 276(1): F88 - F95.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. Delany and E. Canalis
Dual Regulation of Stromelysin-3 by Fibroblast Growth Factor-2 in Murine Osteoblasts
J. Biol. Chem., June 26, 1998; 273(26): 16595 - 16600.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Silacci, J.-M. Dayer, A. Desgeorges, R. Peter, C. Manueddu, and P.-A. Guerne
Interleukin (IL)-6 and Its Soluble Receptor Induce TIMP-1 Expression in Synoviocytes and Chondrocytes, and Block IL-1-induced Collagenolytic Activity
J. Biol. Chem., May 29, 1998; 273(22): 13625 - 13629.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Kusano, C. Miyaura, M. Inada, T. Tamura, A. Ito, H. Nagase, K. Kamoi, and T. Suda
Regulation of Matrix Metalloproteinases (MMP-2, -3, -9, and -13) by Interleukin-1 and Interleukin-6 in Mouse Calvaria: Association of MMP Induction with Bone Resorption
Endocrinology, March 1, 1998; 139(3): 1338 - 1345.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. Franchimont, D. Durant, and E. Canalis
Interleukin-6 and Its Soluble Receptor Regulate the Expression of Insulin-Like Growth Factor Binding Protein-5 in Osteoblast Cultures
Endocrinology, August 1, 1997; 138(8): 3380 - 3386.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Hess, D. Porte, C. Munz, and P. Angel
AP-1 and Cbfa/Runt Physically Interact and Regulate Parathyroid Hormone-dependent MMP13 Expression in Osteoblasts through a New Osteoblast-specific Element 2/AP-1 Composite Element
J. Biol. Chem., June 1, 2001; 276(23): 20029 - 20038.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1997 by the American Society for Biochemistry and Molecular Biology.