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Volume 272, Number 19, Issue of May 9, 1997 pp. 12492-12494
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and beta -Catenin in Cell Adhesion

(Received for publication, March 5, 1997)

Makiko Yamamoto , Ajit Bharti , Yongqing Li and Donald Kufe

From the Division of Cancer Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115

The DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed in human breast carcinomas. The functional role of DF3 is unknown. The present studies demonstrate that DF3 associates with beta -catenin. Similar findings have been obtained for gamma -catenin but not alpha -catenin. DF3, like E-cadherin and the adenomatous polyposis coli gene product, contains an SXXXXXSSL site that is responsible for direct binding to beta -catenin. The results further demonstrate that interaction of DF3 and beta -catenin is dependent on cell adhesion. These findings and the role of beta -catenin in cell signaling support a role for DF3 in the adhesion of epithelial cells.


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Copyright © 1997 by the American Society for Biochemistry and Molecular Biology.