JBC Advanced Peptides, Inc.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ruff, S. J.
Right arrow Articles by Cohen, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ruff, S. J.
Right arrow Articles by Cohen, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Volume 272, Number 2, Issue of January 10, 1997 pp. 1263-1267
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

Peroxovanadate Induces Tyrosine Phosphorylation of Multiple Signaling Proteins in Mouse Liver and Kidney

(Received for publication, August 31, 1996, and in revised form, November 4, 1996)

Susan J. Ruff , Katherine Chen and Stanley Cohen

From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146

The intraperitoneal injection of a vanadate/H2O2 mixture (peroxovanadate) into mice resulted within minutes in the appearance of numerous tyrosine-phosphorylated proteins in the liver and kidney. These effects are presumably due to the inhibition of phosphotyrosine phosphatase activity. Three of the tyrosine-phosphorylated proteins have been identified as the receptors for epidermal growth factor, insulin, and hepatocyte growth factor. The injection of peroxovanadate also enhanced the tyrosine phosphorylation of many of the proteins known to function downstream of these receptors, including SHC, signal transducer and activator of transcription (Stat) 1alpha ,beta , Stat 3, Stat 5, phospholipase C-gamma , insulin receptor substrate 1, GTPase-activating protein, beta -catenin, gamma -catenin, p120cas, SHP-1, and SHP-2. The administration of peroxovanadate also induced nuclear translocation of a number of tyrosine-phosphorylated Stat proteins. In addition, the global effects on tyrosine phosphorylation permitted the detection of a number of novel intracellular protein interactions, including an association of Tyk2 with beta -catenin. The in situ administration of peroxovanadate may prove useful in the search for novel tyrosine-phosphorylated proteins and the identification of new interactions between previously identified tyrosine-phosphorylated substrates.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
S. Cohen
Origins of Growth Factors: NGF and EGF
J. Biol. Chem., December 5, 2008; 283(49): 33793 - 33797.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Nakashima, S. A. Arnold, E. T. Mahoney, S. D. Sithu, Y. P. Zhang, S. E. D'Souza, C. B. Shields, and T. Hagg
Small-Molecule Protein Tyrosine Phosphatase Inhibition as a Neuroprotective Treatment after Spinal Cord Injury in Adult Rats
J. Neurosci., July 16, 2008; 28(29): 7293 - 7303.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Machide, A. Hashigasako, K. Matsumoto, and T. Nakamura
Contact Inhibition of Hepatocyte Growth Regulated by Functional Association of the c-Met/Hepatocyte Growth Factor Receptor and LAR Protein-tyrosine Phosphatase
J. Biol. Chem., March 31, 2006; 281(13): 8765 - 8772.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Sangwan, G. N. Paliouras, A. Cheng, N. Dube, M. L. Tremblay, and M. Park
Protein-tyrosine Phosphatase 1B Deficiency Protects against Fas-induced Hepatic Failure
J. Biol. Chem., January 6, 2006; 281(1): 221 - 228.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
P. R. Cutillas, B. Geering, M. D. Waterfield, and B. Vanhaesebroeck
Quantification of Gel-separated Proteins and Their Phosphorylation Sites by LC-MS Using Unlabeled Internal Standards: Analysis of Phosphoprotein Dynamics in a B Cell Lymphoma Cell Line
Mol. Cell. Proteomics, August 1, 2005; 4(8): 1038 - 1051.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. E. Moran, A. M. Carothers, M. J. Weyant, M. Redston, and M. M. Bertagnolli
Carnosol Inhibits {beta}-Catenin Tyrosine Phosphorylation and Prevents Adenoma Formation in the C57BL/6J/Min/+ (Min/+) Mouse
Cancer Res., February 1, 2005; 65(3): 1097 - 1104.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
N. K. Mukhopadhyay, D. Gilchrist, G. J. Gordon, C.-J. Chen, R. Bueno, M. L. Lu, R. Salgia, D. J. Sugarbaker, and M. T. Jaklitsch
Integrin dependent protein tyrosine phosphorylation is a key regulatory event in collagen IV mediated adhesion and proliferation of human lung tumor cell line, Calu-1
Ann. Thorac. Surg., August 1, 2004; 78(2): 450 - 457.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
K. Schroder, P. J. Hertzog, T. Ravasi, and D. A. Hume
Interferon-{gamma}: an overview of signals, mechanisms and functions
J. Leukoc. Biol., February 1, 2004; 75(2): 163 - 189.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
K. R. Fitch, K. A. McGowan, C. D. van Raamsdonk, H. Fuchs, D. Lee, A. Puech, Y. Herault, D. W. Threadgill, M. H. de Angelis, and G. S. Barsh
Genetics of dark skin in mice
Genes & Dev., January 15, 2003; 17(2): 214 - 228.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. P. Anderson, C. S. Dunn, R. C. Cattley, and J.C. Corton
Hepatocellular proliferation in response to a peroxisome proliferator does not require TNF{alpha} signaling
Carcinogenesis, November 1, 2001; 22(11): 1843 - 1851.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
H. Keilhack, M. Muller, S.-A. Bohmer, C. Frank, K. M. Weidner, W. Birchmeier, T. Ligensa, A. Berndt, H. Kosmehl, B. Gunther, et al.
Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the SH2 Domain Protein Tyrosine Phosphatase SHP-1
J. Cell Biol., January 22, 2001; 152(2): 325 - 334.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. G. N. Garcia, K. L. Schaphorst, A. D. Verin, S. Vepa, C. E. Patterson, and V. Natarajan
Diperoxovanadate alters endothelial cell focal contacts and barrier function: role of tyrosine phosphorylation
J Appl Physiol, December 1, 2000; 89(6): 2333 - 2343.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Nishikawa, Z. Wang, J. Kerns, C. S. Wilcox, and B. I. Carr
Inhibition of Hepatoma Cell Growth in Vitro by Arylating and Non-arylating K Vitamin Analogs. SIGNIFICANCE OF PROTEIN TYROSINE PHOSPHATASE INHIBITION
J. Biol. Chem., December 3, 1999; 274(49): 34803 - 34810.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. L. Furge, K. Chen, and S. Cohen
Annexin VII and Annexin XI Are Tyrosine Phosphorylated in Peroxovanadate-treated Dogs and in Platelet-derived Growth Factor-treated Rat Vascular Smooth Muscle Cells
J. Biol. Chem., November 19, 1999; 274(47): 33504 - 33509.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. A. Scheving, J. R. Thomas, and L. Zhang
Regulation of intestinal tyrosine phosphorylation and programmed cell death by peroxovanadate
Am J Physiol Cell Physiol, September 1, 1999; 277(3): C572 - C579.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Carballo, M. Conde, R. El Bekay, J. Martin-Nieto, M. J. Camacho, J. Monteseirin, J. Conde, F. J. Bedoya, and F. Sobrino
Oxidative Stress Triggers STAT3 Tyrosine Phosphorylation and Nuclear Translocation in Human Lymphocytes
J. Biol. Chem., June 18, 1999; 274(25): 17580 - 17586.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. G. N. Garcia, A. D. Verin, K. Schaphorst, R. Siddiqui, C. E. Patterson, C. Csortos, and V. Natarajan
Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60src
Am J Physiol Lung Cell Mol Physiol, June 1, 1999; 276(6): L989 - L998.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. J. M. Diaz-Guerra, A. Castrillo, P. Martin-Sanz, and L. Bosca
Negative Regulation by Protein Tyrosine Phosphatase of IFN-{gamma}-Dependent Expression of Inducible Nitric Oxide Synthase
J. Immunol., June 1, 1999; 162(11): 6776 - 6783.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
E. Pötter, C. Bergwitz, and G. Brabant
The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues
Endocr. Rev., April 1, 1999; 20(2): 207 - 239.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
A. Baruch, M.-l. Hartmann, M. Yoeli, Y. Adereth, S. Greenstein, Y. Stadler, Y. Skornik, J. Zaretsky, N. I. Smorodinsky, I. Keydar, et al.
The Breast Cancer-associated MUC1 Gene Generates Both a Receptor and Its Cognate Binding Protein
Cancer Res., April 1, 1999; 59(7): 1552 - 1561.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
L Feng, X Zhou, J Liao, and M. Omary
Pervanadate-mediated tyrosine phosphorylation of keratins 8 and 19 via a p38 mitogen-activated protein kinase-dependent pathway
J. Cell Sci., January 7, 1999; 112(13): 2081 - 2090.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
M. Huber, L. Izzi, P. Grondin, C. Houde, T. Kunath, A. Veillette, and N. Beauchemin
The Carboxyl-terminal Region of Biliary Glycoprotein Controls Its Tyrosine Phosphorylation and Association with Protein-tyrosine Phosphatases SHP-1 and SHP-2 in Epithelial Cells
J. Biol. Chem., January 1, 1999; 274(1): 335 - 344.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. R. Simon, U. Rai, B. L. Fanburg, and B. H. Cochran
Activation of the JAK-STAT pathway by reactive oxygen species
Am J Physiol Cell Physiol, December 1, 1998; 275(6): C1640 - C1652.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. J. Zhao and R. Zhao
Purification and Cloning of PZR, a Binding Protein and Putative Physiological Substrate of Tyrosine Phosphatase SHP-2
J. Biol. Chem., November 6, 1998; 273(45): 29367 - 29372.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Feick, S. Gilhaus, and I. Schulz
Pervanadate Stimulates Amylase Release and Protein Tyrosine Phosphorylation of Paxillin and p125FAK in Differentiated AR4-2J Pancreatic Acinar Cells
J. Biol. Chem., June 26, 1998; 273(26): 16366 - 16373.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Olivier, B.-J. Romero-Gallo, C. Matte, J. Blanchette, B. I. Posner, M. J. Tremblay, and R. Faure
Modulation of Interferon-gamma -induced Macrophage Activation by Phosphotyrosine Phosphatases Inhibition. EFFECT ON MURINE LEISHMANIASIS PROGRESSION
J. Biol. Chem., May 29, 1998; 273(22): 13944 - 13949.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. M. Edwards, F. H. Wilford, X. Liu, L. Hennighausen, J. Djiane, and C. H. Streuli
Regulation of Mammary Differentiation by Extracellular Matrix Involves Protein-tyrosine Phosphatases
J. Biol. Chem., April 17, 1998; 273(16): 9495 - 9500.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. J. Haque, Q. Wu, W. Kammer, K. Friedrich, J. M. Smith, I. M. Kerr, G. R. Stark, and B. R. G. Williams
Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1
PNAS, August 5, 1997; 94(16): 8563 - 8568.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1997 by the American Society for Biochemistry and Molecular Biology.