|
|
|
|||||||
|
|||||||||
(Received for publication, April 22, 1996, and in revised form, August 28, 1996)
From the Departments of Nitric oxide (NO) and tumor necrosis factor- The protective effect of SNAP pretreatment on TNF
Volume 272, Number 2,
Issue of January 10, 1997
pp. 1402-1411
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
-induced Apoptosis by Inducing Heat Shock Protein 70 Expression
§
,
,
and
Surgery,
§ Pharmacology, and 
Cell Biology and Physiology,
School of Medicine, University of Pittsburgh,
Pittsburgh, Pennsylvania 15261
(TNF) play important roles in the pathogenesis of liver disease
during acute inflammation. The present study was designed to elucidate
the effect of NO pre-exposure on TNF-induced hepatotoxicity.
Pretreatment of primary cultures of rat hepatocytes with the NO donor
S-nitroso-N-acetylpenicillamine (SNAP) induced
the expression of heat shock protein 70 (HSP70) mRNA and protein,
which was associated with thermotolerance and cytoprotection from
TNF+actinomycin D-induced hepatotoxicity and apoptosis. SNAP
transiently changed the intracellular redox state by inducing
glutathione (GSH) oxidation associated with the formation of
S-nitrosoglutathione (GSNO). HSP70 mRNA was also induced by the GSH-oxidizing agent diamide and the GSH-conjugating agent N-ethylmaleimide, suggesting that NO induces HSP70
expression through GSH oxidation.
-induced apoptosis
correlated with the level of HSP70 expression. SNAP pretreatment inhibited reactive oxygen intermediate generation and lipid
peroxidation effects that were reversed by blocking HSP70 expression
using an antisense oligonucleotide to HSP70. Finally, endogenous NO formation, induced in hepatocytes stimulated with interferon-
and
interleukin-1
, led to the formation of GSNO and GSSG, induced HSP70,
and attenuated TNF-mediated cytotoxicity. These findings demonstrated that NO can induce resistance to TNF-induced
hepatotoxicity, possibly through the stimulation of HSP70
expression.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Lian and X. Zheng HSCARG Regulates NF-{kappa}B Activation by Promoting the Ubiquitination of RelA or COMMD1 J. Biol. Chem., July 3, 2009; 284(27): 17998 - 18006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Zaki, S. Fujii, T. Okamoto, S. Islam, S. Khan, K. A. Ahmed, T. Sawa, and T. Akaike Cytoprotective Function of Heme Oxygenase 1 Induced by a Nitrated Cyclic Nucleotide Formed during Murine Salmonellosis J. Immunol., March 15, 2009; 182(6): 3746 - 3756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Khazaei, M. Habibi-Rezaei, F. Karimzadeh, A. A. Moosavi-Movahedi, A. A. Sarrafnejhad, F. Sabouni, and M. Bakhti Microglial Cell Death Induced by Glycated Bovine Serum Albumin: Nitric Oxide Involvement J. Biochem., August 1, 2008; 144(2): 197 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Kim, P. A. Loughran, J. Rao, T. R. Billiar, and B. S. Zuckerbraun Carbon monoxide activates NF-{kappa}B via ROS generation and Akt pathways to protect against cell death of hepatocytes Am J Physiol Gastrointest Liver Physiol, July 1, 2008; 295(1): G146 - G152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. D. Oberley, J. M. Swanlund, H. J. Zhang, and K. C. Kregel Aging Results in Increased Autophagy of Mitochondria and Protein Nitration in Rat Hepatocytes Following Heat Stress J. Histochem. Cytochem., June 1, 2008; 56(6): 615 - 627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Gazoni, C. G. Tribble, M. Q. Zhao, E. B. Unger, R. A. Farrar, P. I. Ellman, L. G. Fernandez, V. E. Laubach, and I. L. Kron Pulmonary Macrophage Inhibition and Inhaled Nitric Oxide Attenuate Lung Ischemia-Reperfusion Injury Ann. Thorac. Surg., July 1, 2007; 84(1): 247 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mori Regulation of Nitric Oxide Synthesis and Apoptosis by Arginase and Arginine Recycling J. Nutr., June 1, 2007; 137(6): 1616S - 1620S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Kim, K. H. Park, Y. J. Kim, H. J. Park, and D. M. Kim Thermal Injury Induces Heat Shock Protein in the Optic Nerve Head In Vivo Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 4888 - 4894. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hong, Y. Nakano, A. Yokomakura, K. Ishihara, S. Kim, Y.-S. Kang, and K. Ohuchi Nitric Oxide Production by the Vacuolar-Type (H+)-ATPase Inhibitors Bafilomycin A1 and Concanamycin A and Its Possible Role in Apoptosis in RAW 264.7 Cells J. Pharmacol. Exp. Ther., November 1, 2006; 319(2): 672 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Priego, M. Granado, E. Castillero, A. I. Martin, M A. Villanua, and A. Lopez-Calderon Nitric oxide production by hepatocytes contributes to the inhibitory effect of endotoxin on insulin-like growth factor I gene expression. J. Endocrinol., September 1, 2006; 190(3): 847 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Nisoli and M. O. Carruba Nitric oxide and mitochondrial biogenesis J. Cell Sci., July 15, 2006; 119(14): 2855 - 2862. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Tiwari, K. J. Messer, and P. R. Mayeux Inducible Nitric Oxide Synthase and Apoptosis in Murine Proximal Tubule Epithelial Cells Toxicol. Sci., June 1, 2006; 91(2): 493 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Massip-Salcedo, A. Casillas-Ramirez, R. Franco-Gou, R. Bartrons, I. Ben Mosbah, A. Serafin, J. Rosello-Catafau, and C. Peralta Heat Shock Proteins and Mitogen-activated Protein Kinases in Steatotic Livers Undergoing Ischemia-Reperfusion: Some Answers Am. J. Pathol., May 1, 2006; 168(5): 1474 - 1485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Du, Q. Guan, H. Diao, Z. Yin, and A. M. Jevnikar Nitric oxide induces apoptosis in renal tubular epithelial cells through activation of caspase-8 Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1044 - F1054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yoshioka, T. Kitao, T. Kishino, A. Yamamuro, and S. Maeda Nitric oxide protects macrophages from hydrogen peroxide-induced apoptosis by inducing the formation of catalase. J. Immunol., April 15, 2006; 176(8): 4675 - 4681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Manukhina, H. F. Downey, and R. T. Mallet Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia. Experimental Biology and Medicine, April 1, 2006; 231(4): 343 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. J. Mur, T. L. W. Carver, and E. Prats NO way to live; the various roles of nitric oxide in plant-pathogen interactions J. Exp. Bot., February 1, 2006; 57(3): 489 - 505. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liu, K. W. L. Kam, G. H. Borchert, G. M. Kravtsov, H. J. Ballard, and T. M. Wong Further study on the role of HSP70 on Ca2+ homeostasis in rat ventricular myocytes subjected to simulated ischemia Am J Physiol Cell Physiol, February 1, 2006; 290(2): C583 - C591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Mannick Immunoregulatory and antimicrobial effects of nitrogen oxides. Proceedings of the ATS, January 1, 2006; 3(2): 161 - 165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. St. Croix, K. Leelavaninchkul, S. C. Watkins, V. E. Kagan, and B. R. Pitt Nitric Oxide and Zinc Homeostasis in Acute Lung Injury Proceedings of the ATS, October 1, 2005; 2(3): 236 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wang, J. J. Brems, R. L. Gamelli, and J. Ding Reversibility of Caspase Activation and Its Role during Glycochenodeoxycholate-induced Hepatocyte Apoptosis J. Biol. Chem., June 24, 2005; 280(25): 23490 - 23495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hong, A. Yokomakura, Y. Nakano, H. S. Ban, K. Ishihara, J.-W. Ahn, O. Zee, and K. Ohuchi Induction of Nitric Oxide Production by the Cytostatic Macrolide Apicularen A [2,4-Heptadienamide, N-[(1E)-3-[(3S,5R,7R,9S)-3,4,5,6,7,8,9,10-octahydro-7,14 Dihydroxy-1-oxo-5,9-epoxy-1H-2-benzoxacyclododecin-3-yl]-1 propenyl]-, (2Z,4Z)-(9CI)] and Possible Role of Nitric Oxide in Apicularen A-Induced Apoptosis in RAW 264.7 Cells J. Pharmacol. Exp. Ther., March 1, 2005; 312(3): 968 - 977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Lee, K.-M. Kim, S. Namkoong, C.-K. Kim, Y.-C. Kang, H. Lee, K.-S. Ha, J.-A Han, H.-T. Chung, Y.-G. Kwon, et al. Nitric Oxide Inhibition of Homocysteine-induced Human Endothelial Cell Apoptosis by Down-regulation of p53-dependent Noxa Expression through the Formation of S-Nitrosohomocysteine J. Biol. Chem., February 18, 2005; 280(7): 5781 - 5788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Jeong, K. Y. Lee, D. Shin, H. Chung, S. H. Jeon, and R. H. Seong Nitric Oxide Inhibits Glucocorticoid-induced Apoptosis of Thymocytes by Repressing the SRG3 Expression J. Biol. Chem., August 13, 2004; 279(33): 34373 - 34379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, K. W. L. Kam, J.-J. Zhou, W.-Y. Yan, M. Chen, S. Wu, and T. M. Wong Effects of Heat Shock Protein 70 Activation by Metabolic Inhibition Preconditioning or {kappa}-Opioid Receptor Stimulation on Ca2+ Homeostasis in Rat Ventricular Myocytes Subjected to Ischemic Insults J. Pharmacol. Exp. Ther., August 1, 2004; 310(2): 606 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Na, S.-J. Lee, Y.-C. Kang, Y.-L. Cho, W.-D. Nam, P. K. M. Kim, K.-S. Ha, H.-T. Chung, H. Lee, Y.-G. Kwon, et al. Inhibition of Farnesyltransferase Prevents Collagen-Induced Arthritis by Down-Regulation of Inflammatory Gene Expression through Suppression of p21ras-Dependent NF-{kappa}B Activation J. Immunol., July 15, 2004; 173(2): 1276 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yamashita, S. Akamine, Y. Sumida, M. Inoue, T. Sawada, T. Nagayasu, and T. Oka Inhaled nitric oxide attenuates apoptosis in ischemia-reperfusion injury of the rabbit lung Ann. Thorac. Surg., July 1, 2004; 78(1): 292 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Beere `The stress of dying': the role of heat shock proteins in the regulation of apoptosis J. Cell Sci., June 1, 2004; 117(13): 2641 - 2651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O. Velardez, A. H. Poliandri, J. P. Cabilla, C. C. A. Bodo, L. I. Machiavelli, and B. H. Duvilanski Long-Term Treatment of Anterior Pituitary Cells with Nitric Oxide Induces Programmed Cell Death Endocrinology, April 1, 2004; 145(4): 2064 - 2070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Reinehr, B. Gorg, A. Hongen, and D. Haussinger CD95-tyrosine Nitration Inhibits Hyperosmotic and CD95 Ligand-induced CD95 Activation in Rat Hepatocytes J. Biol. Chem., March 12, 2004; 279(11): 10364 - 10373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Gong, A. I. Cederbaum, and N. Nieto The Liver-Selective Nitric Oxide Donor O2-Vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) Protects HepG2 Cells against Cytochrome P450 2E1-Dependent Toxicity Mol. Pharmacol., January 1, 2004; 65(1): 130 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Zuckerbraun, T. R. Billiar, S. L. Otterbein, P. K.M. Kim, F. Liu, A. M.K. Choi, F. H. Bach, and L. E. Otterbein Carbon Monoxide Protects against Liver Failure through Nitric Oxide-induced Heme Oxygenase 1 J. Exp. Med., December 1, 2003; 198(11): 1707 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tedeschi, M. Menegazzi, D. Margotto, H. Suzuki, U. Forstermann, and H. Kleinert Anti-Inflammatory Actions of St. John's Wort: Inhibition of Human Inducible Nitric-Oxide Synthase Expression by Down-Regulating Signal Transducer and Activator of Transcription-1{alpha} (STAT-1{alpha}) Activation J. Pharmacol. Exp. Ther., October 1, 2003; 307(1): 254 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Bykov, H. Jarvelainen, and K. Lindros L-CARNITINE ALLEVIATES ALCOHOL-INDUCED LIVER DAMAGE IN RATS: ROLE OF TUMOUR NECROSIS FACTOR-ALPHA Alcohol Alcohol., September 1, 2003; 38(5): 400 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. C. Boo and H. Jo Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases Am J Physiol Cell Physiol, September 1, 2003; 285(3): C499 - C508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-S. HA, K.-M. KIM, Y.-G. KWON, S.-K. BAI, W.-D. NAM, Y.-M. YOO, P. K. M. KIM, H.-T. CHUNG, T. R. BILLIAR, and Y.-M. KIM Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation FASEB J, June 1, 2003; 17(9): 1036 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yao, M. Hausding, G. Erkel, T. Anke, U. Forstermann, and H. Kleinert Sporogen, S14-95, and S-Curvularin, Three Inhibitors of Human Inducible Nitric-Oxide Synthase Expression Isolated from Fungi Mol. Pharmacol., February 1, 2003; 63(2): 383 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Park, H.-J. Na, Y.-G. Kwon, K.-S. Ha, S.-J. Lee, C.-K. Kim, K.-S. Lee, T. Yoneyama, K. Hatakeyama, P. K. M. Kim, et al. Nitric Oxide (NO) Pretreatment Increases Cytokine-induced NO Production in Cultured Rat Hepatocytes by Suppressing GTP Cyclohydrolase I Feedback Inhibitory Protein Level and Promoting Inducible NO Synthase Dimerization J. Biol. Chem., November 27, 2002; 277(49): 47073 - 47079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. M. Kim, Y. Wang, A. Gambotto, Y.-M. Kim, R. Weller, B. S. Zuckerbraun, Y. Hua, S. C. Watkins, and T. R. Billiar Hepatocyte Fas-associating Death Domain Protein/Mediator of Receptor-induced Toxicity (FADD/MORT1) Levels Increase in Response to Pro-apoptotic Stimuli J. Biol. Chem., October 4, 2002; 277(41): 38855 - 38862. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Xu Role of Heat Shock Proteins in Atherosclerosis Arterioscler. Thromb. Vasc. Biol., October 1, 2002; 22(10): 1547 - 1559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Dobbin, N. C. Smith, and A. M. Johnson Heat Shock Protein 70 Is a Potential Virulence Factor in Murine Toxoplasma Infection Via Immunomodulation of Host NF-{kappa}B and Nitric Oxide J. Immunol., July 15, 2002; 169(2): 958 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. J. Kang, S. J. Seo, H. S. Yun-Choi, D. H. Lee, Y.-M. Kim, and K. C. Chang A Synthetic Isoquinoline Alkaloid, 1-(beta -Naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), Reduces Inducible Nitric Oxide Synthase Expression and Improves Survival in a Rodent Model of Endotoxic Shock J. Pharmacol. Exp. Ther., May 1, 2002; 301(2): 561 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Torok, H. Higuchi, S. Bronk, and G. J. Gores Nitric Oxide Inhibits Apoptosis Downstream of Cytochrome c Release by Nitrosylating Caspase 9 Cancer Res., March 1, 2002; 62(6): 1648 - 1653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. K. Song, T. R. Billiar, and Y. J. Lee Role of Galectin-3 in Breast Cancer Metastasis : Involvement of Nitric Oxide Am. J. Pathol., March 1, 2002; 160(3): 1069 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, J. E. Saavedra, T. Lu, J.-G. Song, J. Clark, M. P. Waalkes, and L. K. Keefer O2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate Protection Against D-Galactosamine/Endotoxin-Induced Hepatotoxicity in Mice: Genomic Analysis Using Microarrays J. Pharmacol. Exp. Ther., January 1, 2002; 300(1): 18 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Gottschling, R. R. Maronpot, J. R. Hailey, S. Peddada, C. R. Moomaw, J. E. Klaunig, and A. Nyska The Role of Oxidative Stress in Indium Phosphide-Induced Lung Carcinogenesis in Rats Toxicol. Sci., November 1, 2001; 64(1): 28 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Johnson, T. L. Macdonald, J. B. Mannick, M. R. Conaway, and B. Gaston Accelerated S-Nitrosothiol Breakdown by Amyotrophic Lateral Sclerosis Mutant Copper,Zinc-Superoxide Dismutase J. Biol. Chem., October 19, 2001; 276(43): 39872 - 39878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R D Rakhit and M S Marber Nitric oxide: an emerging role in cardioprotection? Heart, October 1, 2001; 86(4): 368 - 372. [Full Text] [PDF]
|
|
|
|
|
|
M. Jaiswal, N. F. LaRusso, and G. J. Gores Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis Am J Physiol Gastrointest Liver Physiol, September 1, 2001; 281(3): G626 - G634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fiorucci, E. Distrutti, M. N. Ajuebor, A. Mencarelli, R. Mannucci, B. Palazzetti, P. Del Soldato, A. Morelli, and J. L. Wallace NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines Am J Physiol Gastrointest Liver Physiol, September 1, 2001; 281(3): G654 - G665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S Latchman Heat shock proteins and cardiac protection Cardiovasc Res, September 1, 2001; 51(4): 637 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Nadler, E. C. Dickinson, D. Beer-Stolz, S. M. Alber, S. C. Watkins, D. W. Pratt, and H. R. Ford Scavenging nitric oxide reduces hepatocellular injury after endotoxin challenge Am J Physiol Gastrointest Liver Physiol, July 1, 2001; 281(1): G173 - G181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-J. Zhou, J.-M. Pei, G.-Y. Wang, S. Wu, W.-P. Wang, C.-H. Cho, and T.-M. Wong Inducible HSP70 mediates delayed cardioprotection via U-50488H pretreatment in rat ventricular myocytes Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H40 - H47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Tendler, C. Bao, T. Wang, E. L. Huang, E. A. Ratovitski, D. A. Pardoll, and C. J. Lowenstein Intersection of Interferon and Hypoxia Signal Transduction Pathways in Nitric Oxide-induced Tumor Apoptosis Cancer Res., May 1, 2001; 61(9): 3682 - 3688. [Abstract] [Full Text]
|
|
|
|
|
|
F. Tsukahara, T. Yoshioka, and T. Muraki Molecular and Functional Characterization of HSC54, a Novel Variant of Human Heat-Shock Cognate Protein 70 Mol. Pharmacol., April 13, 2001; 58(6): 1257 - 1263. [Abstract] [Full Text]
|
|
|
|
 |
|
 P J Roberts, G P Riley, K Morgan, R Miller, J O Hunter, and S J Middleton The physiological expression of inducible nitric oxide synthase (iNOS) in the human colon J. Clin. Pathol., April 1, 2001; 54(4): 293 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Adrie, C. Richter, M. Bachelet, N. Banzet, D. Francois, A. T. Dinh-Xuan, J. F. Dhainaut, B. S. Polla, and M.-J. Richard Contrasting effects of NO and peroxynitrites on HSP70 expression and apoptosis in human monocytes Am J Physiol Cell Physiol, August 1, 2000; 279(2): C452 - C460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, L. He, S. H. Ahmed, S.-W. Chen, M. P. Goldberg, J. S. Beckman, C. Y. Hsu, and C. Iadecola Oxygen-Glucose Deprivation Induces Inducible Nitric Oxide Synthase and Nitrotyrosine Expression in Cerebral Endothelial Cells Editorial Comment Stroke, July 1, 2000; 31(7): 1744 - 1751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Vakkala, K. Kahlos, E. Lakari, P. Pääkkö, V. Kinnula, and Y. Soini Inducible Nitric Oxide Synthase Expression, Apoptosis, and Angiogenesis in in Situ and Invasive Breast Carcinomas Clin. Cancer Res., June 1, 2000; 6(6): 2408 - 2416. [Abstract] [Full Text]
|
|
|
|
|
|
E. Hatano, C. A. Bradham, A. Stark, Y. Iimuro, J. J. Lemasters, and D. A. Brenner The Mitochondrial Permeability Transition Augments Fas-induced Apoptosis in Mouse Hepatocytes J. Biol. Chem., April 14, 2000; 275(16): 11814 - 11823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-M. Kim, H.-T. Chung, R. L. Simmons, and T. R. Billiar Cellular Non-heme Iron Content Is a Determinant of Nitric Oxide-mediated Apoptosis, Necrosis, and Caspase Inhibition J. Biol. Chem., April 6, 2000; 275(15): 10954 - 10961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. G. Seo, T. Nishinaka, and C. Yabe-Nishimura Nitric Oxide Up-Regulates Aldose Reductase Expression in Rat Vascular Smooth Muscle Cells: A Potential Role for Aldose Reductase in Vascular Remodeling Mol. Pharmacol., April 1, 2000; 57(4): 709 - 717. [Abstract] [Full Text]
|
|
|
|
 |
|
 C L Potter and P J Hanson Exogenous nitric oxide inhibits apoptosis in guinea pig gastric mucous cells Gut, February 1, 2000; 46(2): 156 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z Dastoor and J Dreyer Nuclear translocation and aggregate formation of heat shock cognate protein 70 (Hsc70) in oxidative stress and apoptosis J. Cell Sci., January 8, 2000; 113(16): 2845 - 2854. [Abstract] [PDF]
|
|
|
|
 |
|
 K. B. Seydel, S. J. Smith, and S. L. Stanley Jr. Innate Immunity to Amebic Liver Abscess Is Dependent on Gamma Interferon and Nitric Oxide in a Murine Model of Disease Infect. Immun., January 1, 2000; 68(1): 400 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Plumpe, N. P. Malek, C.-T. Bock, T. Rakemann, M. P. Manns, and C. Trautwein NF-kappa B determines between apoptosis and proliferation in hepatocytes during liver regeneration Am J Physiol Gastrointest Liver Physiol, January 1, 2000; 278(1): G173 - G183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Akbay, K Cinar, O Uzunalimoglu, S Eranil, C Yurdaydin, H Bozkaya, and M Bozdayi Serum cytotoxin and oxidant stress markers in N-acetylcysteine treated thioacetamide hepatotoxicity of rats Human and Experimental Toxicology, November 1, 1999; 18(11): 669 - 676. [Abstract] [PDF]
|
|
|
|
|
|
C. DIDIER, N. EMONET-PICCARDI, J.-C. BéANI, J. CADET, and M.-J. RICHARD L-arginine increases UVA cytotoxicity in irradiated human keratinocyte cell line: potential role of nitric oxide FASEB J, October 1, 1999; 13(13): 1817 - 1824. [Abstract] [Full Text]
|
|
|
|
|
|
K. B. Sandau, D. Callsen, and B. Brüne Protection against Nitric Oxide-Induced Apoptosis in Rat Mesangial Cells Demands Mitogen-Activated Protein Kinases and Reduced Glutathione Mol. Pharmacol., October 1, 1999; 56(4): 744 - 751. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y.-M. Kim, H.-T. Chung, S.-S. Kim, J.-A Han, Y.-M. Yoo, K.-M. Kim, G.-H. Lee, H.-Y. Yun, A. Green, J. Li, et al. Nitric Oxide Protects PC12 Cells from Serum Deprivation-Induced Apoptosis by cGMP-Dependent Inhibition of Caspase Signaling J. Neurosci., August 15, 1999; 19(16): 6740 - 6747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D Rakhit, R. J Edwards, and M. S Marber Nitric oxide, nitrates and ischaemic preconditioning Cardiovasc Res, August 15, 1999; 43(3): 621 - 627. [Full Text] [PDF]
|
|
|
|
|
|
K. Guzik, J. Dobrucki, and J. Pryjma Heat-Shocked Monocytes Are Resistant to Staphylococcus aureus-Induced Apoptotic DNA Fragmentation due to Expression of HSP72 Infect. Immun., August 1, 1999; 67(8): 4216 - 4222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Furuke, P. R. Burd, J. A. Horvath-Arcidiacono, K. Hori, H. Mostowski, and E. T. Bloom Human NK Cells Express Endothelial Nitric Oxide Synthase, and Nitric Oxide Protects Them from Activation-Induced Cell Death by Regulating Expression of TNF-{alpha} J. Immunol., August 1, 1999; 163(3): 1473 - 1480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sciorati, P. Rovere, M. Ferrarini, C. Paolucci, S. Heltai, R. Vaiani, E. Clementi, and A. A. Manfredi Generation of Nitric Oxide by the Inducible Nitric Oxide Synthase Protects {gamma}{delta} T Cells from Mycobacterium tuberculosis-Induced Apoptosis J. Immunol., August 1, 1999; 163(3): 1570 - 1576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wright, G. Kolios, J. Westwick, and S. G. Ward Cytokine-induced Apoptosis in Epithelial HT-29 Cells Is Independent of Nitric Oxide Formation. EVIDENCE FOR AN INTERLEUKIN-13-DRIVEN PHOSPHATIDYLINOSITOL 3-KINASE-DEPENDENT SURVIVAL MECHANISM J. Biol. Chem., June 11, 1999; 274(24): 17193 - 17201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, C. A. Bombeck, S. Yang, Y.-M. Kim, and T. R. Billiar Nitric Oxide Suppresses Apoptosis via Interrupting Caspase Activation and Mitochondrial Dysfunction in Cultured Hepatocytes J. Biol. Chem., June 11, 1999; 274(24): 17325 - 17333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Latour and P. Buc-Calderon Survival and Metabolic Function of Freshly Isolated Rat Hepatocytes Exposed First to a Heat Shock and Then to an Oxidative Stress International Journal of Toxicology, June 1, 1999; 18(4): 239 - 244. [Abstract] [PDF]
|
|
|
|
|
|
J. Li and T. R. Billiar IV. Determinants of nitric oxide protection and toxicity in liver Am J Physiol Gastrointest Liver Physiol, May 1, 1999; 276(5): G1069 - G1073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li, Z. M. Marshall, and A. R. Whorton Stimulation of cystine uptake by nitric oxide: regulation of endothelial cell glutathione levels Am J Physiol Cell Physiol, April 1, 1999; 276(4): C803 - C811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rossig, B. Fichtlscherer, K. Breitschopf, J. Haendeler, A. M. Zeiher, A. Mulsch, and S. Dimmeler Nitric Oxide Inhibits Caspase-3 by S-Nitrosation in Vivo J. Biol. Chem., March 12, 1999; 274(11): 6823 - 6826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Morikawa, Y. Kato, T. Sugiyama, N. Koide, D. Chakravortty, T. Yoshida, and T. Yokochi Role of Nitric Oxide in Lipopolysaccharide-Induced Hepatic Injury in D-Galactosamine-Sensitized Mice as an Experimental Endotoxic Shock Model Infect. Immun., March 1, 1999; 67(3): 1018 - 1024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Lang, G. J. Nystrom, and R. A. Frost Regulation of IGF binding protein-1 in Hep G2 cells by cytokines and reactive oxygen species Am J Physiol Gastrointest Liver Physiol, March 1, 1999; 276(3): G719 - G727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-M. Kim, C. A. Bombeck, and T. R. Billiar Nitric Oxide as a Bifunctional Regulator of Apoptosis Circ. Res., February 19, 1999; 84(3): 253 - 256. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Koglin, D. J. Granville, T. Glysing-Jensen, J. S. Mudgett, C. M. Carthy, B. M. McManus, and M. E. Russell Attenuated Acute Cardiac Rejection in NOS2 -/- Recipients Correlates With Reduced Apoptosis Circulation, February 16, 1999; 99(6): 836 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Ing, J. Zang, V. J. Dzau, K. A. Webster, and N. H. Bishopric Modulation of Cytokine-Induced Cardiac Myocyte Apoptosis by Nitric Oxide, Bak, and Bcl-x Circ. Res., January 22, 1999; 84(1): 21 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Scarim, M. R. Heitmeier, and J. A. Corbett Heat Shock Inhibits Cytokine-Induced Nitric Oxide Synthase Expression by Rat and Human Islets Endocrinology, December 1, 1998; 139(12): 5050 - 5057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-M. Kim, T.-H. Kim, D.-W. Seol, R. V. Talanian, and T. R. Billiar Nitric Oxide Suppression of Apoptosis Occurs in Association with an Inhibition of Bcl-2 Cleavage and Cytochrome c Release J. Biol. Chem., November 20, 1998; 273(47): 31437 - 31441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Liu, L. S. Khemlani, R. A. Shapiro, M. L. Johnson, K. Liu, D. A. Geller, S. C. Watkins, S. M. Goyert, and T. R. Billiar Expression of CD14 by Hepatocytes: Upregulation by Cytokines during Endotoxemia Infect. Immun., November 1, 1998; 66(11): 5089 - 5098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Jones and M. J. Czaja III. Intracellular signaling in response to toxic liver injury Am J Physiol Gastrointest Liver Physiol, November 1, 1998; 275(5): G874 - G878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-M. Kim, R. V. Talanian, J. Li, and T. R. Billiar Nitric Oxide Prevents IL-1{beta} and IFN-{gamma}-Inducing Factor (IL-18) Release from Macrophages by Inhibiting Caspase-1 (IL-1{beta}-Converting Enzyme) J. Immunol., October 15, 1998; 161(8): 4122 - 4128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Ceneviva, E. Tzeng, D. G. Hoyt, E. Yee, A. Gallagher, J. F. Engelhardt, Y.-M. Kim, T. R. Billiar, S. A. Watkins, and B. R. Pitt Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells Am J Physiol Lung Cell Mol Physiol, October 1, 1998; 275(4): L717 - L728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xu, S. Bialik, B. E. Jones, Y. Iimuro, R. N. Kitsis, A. Srinivasan, D. A. Brenner, and M. J. Czaja NF-kappa B inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis Am J Physiol Cell Physiol, October 1, 1998; 275(4): C1058 - C1066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ambs, M. O. Ogunfusika, W. G. Merriam, W. P. Bennett, T. R. Billiar, and C. C. Harris Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice PNAS, July 21, 1998; 95(15): 8823 - 8828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sekkai, F. Aillet, N. Israel, and M. Lepoivre Inhibition of NF-kappa B and HIV-1 Long Terminal Repeat Transcriptional Activation by Inducible Nitric Oxide Synthase 2 Activity J. Biol. Chem., February 13, 1998; 273(7): 3895 - 3900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Mangipudy, P. S. Rao, A. Andrews, T. J. Bucci, F. A. Witzmann, and H. M. Mehendale Dose-Dependent Modulation of Cell Death: Apoptosis Versus Necrosis in Thioacetamide Hepatotoxicity International Journal of Toxicology, February 1, 1998; 17(2): 193 - 211. [Abstract] [PDF]
|
|
|
|
|
|
P. Rauhala and C. C. Chiueh Neuroprotection by S-nitrosoglutathione of brain dopamine neurons from oxidative stress FASEB J, February 1, 1998; 12(2): 165 - 173. [Abstract] [Full Text]
|
|
|
|
 |
|
 R.J. Moen, K. P. LaVoi, M. Zhang, and M. J. Blake Clonidine-Induced Heat-Shock Protein Expression in Rat Aorta Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1998; 3(2): 171 - 184. [Abstract] [PDF]
|
|
|
|
|
|
S. Dimmeler, V. Rippmann, U. Weiland, J. Haendeler, and A. M. Zeiher Angiotensin II Induces Apoptosis of Human Endothelial Cells : Protective Effect of Nitric Oxide Circ. Res., December 19, 1997; 81(6): 970 - 976. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-M. Kim, R. V. Talanian, and T. R. Billiar Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms J. Biol. Chem., December 5, 1997; 272(49): 31138 - 31148. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |