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(Received for publication, September 5, 1996)
From the Cutaneous Biology Research Center, Department of
Dermatology, Massachusetts General Hospital, Harvard Medical
School, Charlestown, Massachusetts 02129
Maxadilan is a potent vasodilator peptide
isolated from salivary gland lysates of the sand fly Lutzomyia
longipalpis, a vector of leishmaniasis. The peptide aids the fly
in obtaining blood from the skin of its vertebrate hosts but the
mammalian receptor through which this insect ligand acts was unknown.
We demonstrate that maxadilan is an agonist of the type I receptor for
pituitary adenylate cyclase activating peptide, a neuropeptide with
vascular activity. This surprising observation is a unique example of
convergent evolution from a functional standpoint as these two peptides
do not share significant sequence homology.
Volume 272, Number 2,
Issue of January 10, 1997
pp. 966-970
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
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