| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, February 24, 1997, and in revised form, March 21, 1997)
From the Third Division, Department of Medicine, Kobe University
School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650 Japan
Leptin, secreted by adipocytes, regulates satiety
and energy expenditure. Several forms of leptin receptors produced by
alternative mRNA splicing are found in many tissues, including the
hypothalamus, liver, lung, kidney, hematopoietic cells, and gonads,
suggesting that leptin exerts effects in these tissues. In accordance
with the distribution of leptin receptors, there is accumulating
evidence that leptin plays various roles in reproduction,
hematopoiesis, and the immune systems in addition to the regulation of
food intake and energy expenditure. In the present study, we examined
the in vitro effects of leptin on proliferation of a mouse
embryonic cell line, C3H10T1/2, and its mechanism of action. Leptin
caused a dose- and time-dependent increase in
mitogen-activated protein kinase (MAPK) activity that was accompanied
by an increase in C3H10T1/2 cell number. The MAPK kinase-1-specific
inhibitor PD98059 completely blocked the increases in both MAPK
activity and cell proliferation caused by leptin. These findings
indicate that leptin stimulates the proliferation of C3H10T1/2 cells
via the MAPK cascade.
Volume 272, Number 20,
Issue of May 16, 1997
pp. 12897-12900
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
COMMUNICATION:
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Martin, V. David, L. Malaval, M.-H. Lafage-Proust, L. Vico, and T. Thomas Opposite Effects of Leptin on Bone Metabolism: A Dose-Dependent Balance Related to Energy Intake and Insulin-Like Growth Factor-I Pathway Endocrinology, July 1, 2007; 148(7): 3419 - 3425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. F. Si, J. Li, X. W. Lu, and Y. Jin Suppressive Effects of Leflunomide on Leptin-Induced Collagen I Production Involved in Hepatic Stellate Cell Proliferation Experimental Biology and Medicine, March 1, 2007; 232(3): 427 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Pino, J. M. Rodriguez, S. Rios, P. Astudillo, L. Leiva, G. Seitz, M. Fernandez, and J P. Rodriguez Aromatase activity of human mesenchymal stem cells is stimulated by early differentiation, vitamin D and leptin J. Endocrinol., December 1, 2006; 191(3): 715 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Martin, R. de Vittoris, V. David, R. Moraes, M. Begeot, M.-H. Lafage-Proust, C. Alexandre, L. Vico, and T. Thomas Leptin Modulates both Resorption and Formation while Preventing Disuse-Induced Bone Loss in Tail-Suspended Female Rats Endocrinology, August 1, 2005; 146(8): 3652 - 3659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Ramos, B. R. Rueda, P. C. Leavis, and R. R. Gonzalez Leptin Serves as an Upstream Activator of an Obligatory Signaling Cascade in the Embryo-Implantation Process Endocrinology, February 1, 2005; 146(2): 694 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Craig, H. Zhu, P. W. Dyce, J. Petrik, and J. Li Leptin Enhances Oocyte Nuclear and Cytoplasmic Maturation via the Mitogen-Activated Protein Kinase Pathway Endocrinology, November 1, 2004; 145(11): 5355 - 5363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. C. Russo, S. Metaxas, K. Kobayashi, M. Harris, and G. A. Werther Antiapoptotic Effects of Leptin in Human Neuroblastoma Cells Endocrinology, September 1, 2004; 145(9): 4103 - 4112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yin, D. Wang, H. Zhang, X. Yi, X. Sun, B. Shi, H. Wu, G. Wu, X. Wang, and Y. Shang Molecular Mechanisms Involved in the Growth Stimulation of Breast Cancer Cells by Leptin Cancer Res., August 15, 2004; 64(16): 5870 - 5875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Gonzalez, B. R. Rueda, M. P. Ramos, R. D. Littell, S. Glasser, and P. C. Leavis Leptin-Induced Increase in Leukemia Inhibitory Factor and Its Receptor by Human Endometrium Is Partially Mediated by Interleukin 1 Receptor Signaling Endocrinology, August 1, 2004; 145(8): 3850 - 3857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Tajmir, R. B. Ceddia, R.-K. Li, I. R. Coe, and G. Sweeney Leptin Increases Cardiomyocyte Hyperplasia via Extracellular Signal-Regulated Kinase- and Phosphatidylinositol 3-Kinase-Dependent Signaling Pathways Endocrinology, April 1, 2004; 145(4): 1550 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tabe, M. Konopleva, M. F. Munsell, F. C. Marini, C. Zompetta, T. McQueen, T. Tsao, S. Zhao, S. Pierce, J. Igari, et al. PML-RAR{alpha} is associated with leptin-receptor induction: the role of mesenchymal stem cell-derived adipocytes in APL cell survival Blood, March 1, 2004; 103(5): 1815 - 1822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Cao, K. M. Mak, C. Ren, and C. S. Lieber Leptin Stimulates Tissue Inhibitor of Metalloproteinase-1 in Human Hepatic Stellate Cells: RESPECTIVE ROLES OF THE JAK/STAT AND JAK-MEDIATED H2O2-DEPENDENT MAPK PATHWAYS J. Biol. Chem., February 6, 2004; 279(6): 4292 - 4304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bjorbaek and B. B. Kahn Leptin Signaling in the Central Nervous System and the Periphery Recent Prog. Horm. Res., January 1, 2004; 59(1): 305 - 331. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Zabeau, D. Defeau, J. Van der Heyden, H. Iserentant, J. Vandekerckhove, and J. Tavernier Functional Analysis of Leptin Receptor Activation Using a Janus Kinase/Signal Transducer and Activator of Transcription Complementation Assay Mol. Endocrinol., January 1, 2004; 18(1): 150 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Gonzalez, K. Leary, J. C. Petrozza, and P. C. Leavis Leptin regulation of the interleukin-1 system in human endometrial cells Mol. Hum. Reprod., March 1, 2003; 9(3): 151 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B.S. Harris, T. D. Mitchell, and S. Hebert Leptin-Induced Changes in Body Composition in High Fat-Fed Mice Experimental Biology and Medicine, January 1, 2003; 228(1): 24 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kveiborg, R. Chiusaroli, N. A. Sims, M. Wu, G. Sabatakos, W. C. Horne, and R. Baron The Increased Bone Mass in {Delta}FosB Transgenic Mice Is Independent of Circulating Leptin Levels Endocrinology, November 1, 2002; 143(11): 4304 - 4309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawamura, N. Sato, J. Fukuda, H. Kodama, J. Kumagai, H. Tanikawa, A. Nakamura, and T. Tanaka Leptin Promotes the Development of Mouse Preimplantation Embryos in Vitro Endocrinology, May 1, 2002; 143(5): 1922 - 1931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Machinal-Quelin, M. N. Dieudonne, M. C. Leneveu, R. Pecquery, and Y. Giudicelli Proadipogenic effect of leptin on rat preadipocytes in vitro: activation of MAPK and STAT3 signaling pathways Am J Physiol Cell Physiol, April 1, 2002; 282(4): C853 - C863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takekoshi, K. Ishii, T. Nanmoku, S. Shibuya, Y. Kawakami, K. Isobe, and T. Nakai Leptin Stimulates Catecholamine Synthesis in a PKC-Dependent Manner in Cultured Porcine Adrenal Medullary Chromaffin Cells Endocrinology, November 1, 2001; 142(11): 4861 - 4871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Brannian, S. M. Schmidt, D. O. Kreger, and K. A. Hansen Baseline non-fasting serum leptin concentration to body mass index ratio is predictive of IVF outcomes Hum. Reprod., September 1, 2001; 16(9): 1819 - 1826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Burguera, L. C. Hofbauer, T. Thomas, F. Gori, G. L. Evans, S. Khosla, B. L. Riggs, and R. T. Turner Leptin Reduces Ovariectomy-Induced Bone Loss in Rats Endocrinology, August 1, 2001; 142(8): 3546 - 3553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takekoshi, K. Ishii, Y. Kawakami, K. Isobe, T. Nanmoku, and T. Nakai Ca2+ Mobilization, Tyrosine Hydroxylase Activity, and Signaling Mechanisms in Cultured Porcine Adrenal Medullary Chromaffin Cells: Effects of Leptin Endocrinology, January 1, 2001; 142(1): 290 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. ATTOUB, V. NOE, L. PIROLA, E. BRUYNEEL, E. CHASTRE, M. MAREEL, M. P. WYMANN, and C. GESPACH Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, Rho-, and Rac-dependent signaling pathways FASEB J, November 1, 2000; 14(14): 2329 - 2338. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. Fantuzzi and R. Faggioni Leptin in the regulation of immunity, inflammation, and hematopoiesis J. Leukoc. Biol., October 1, 2000; 68(4): 437 - 446. [Abstract] [Full Text]
|
|
|
|
|
|
A. S. Banks, S. M. Davis, S. H. Bates, and M. G. Myers Jr. Activation of Downstream Signals by the Long Form of the Leptin Receptor J. Biol. Chem., May 5, 2000; 275(19): 14563 - 14572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Jaiswal, N. Jaiswal, S. P. Bruder, G. Mbalaviele, D. R. Marshak, and M. F. Pittenger Adult Human Mesenchymal Stem Cell Differentiation to the Osteogenic or Adipogenic Lineage Is Regulated by Mitogen-activated Protein Kinase J. Biol. Chem., March 24, 2000; 275(13): 9645 - 9652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Harvey, N. G. McKay, K. S. Walker, J. Van der Kaay, C. P. Downes, and M. L. J. Ashford Essential Role of Phosphoinositide 3-Kinase in Leptin-induced KATP Channel Activation in the Rat CRI-G1 Insulinoma Cell Line J. Biol. Chem., February 18, 2000; 275(7): 4660 - 4669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Paolisso, M. R. Tagliamonte, M. Galderisi, G. A. Zito, A. Petrocelli, C. Carella, O. de Divitiis, and M. Varricchio Plasma Leptin Level Is Associated With Myocardial Wall Thickness in Hypertensive Insulin-Resistant Men Hypertension, November 1, 1999; 34(5): 1047 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Li and J. M. Friedman Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction PNAS, August 17, 1999; 96(17): 9677 - 9682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Barkan, H. Jia, A. Dantes, L. Vardimon, A. Amsterdam, and M. Rubinstein Leptin Modulates the Glucocorticoid-Induced Ovarian Steroidogenesis Endocrinology, April 1, 1999; 140(4): 1731 - 1738. [Abstract] [Full Text]
|
|
|
|
|
|
R. B. S. Harris Parabiosis between db/db and ob/ob or db/+ Mice Endocrinology, January 1, 1999; 140(1): 138 - 145. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Faggioni, G. Fantuzzi, C. Gabay, A. Moser, C. A. Dinarello, K. R. Feingold, and C. Grunfeld Leptin deficiency enhances sensitivity to endotoxin-induced lethality Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R136 - R142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bouloumie, H. C. A. Drexler, M. Lafontan, and R. Busse Leptin, the Product of Ob Gene, Promotes Angiogenesis Circ. Res., November 16, 1998; 83(10): 1059 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. McCowen, J. C. Chow, and R. J. Smith Leptin Signaling in the Hypothalamus of Normal Rats in Vivo Endocrinology, November 1, 1998; 139(11): 4442 - 4447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Morton, V. Emilsson, Y.-L. Liu, and M. A. Cawthorne Leptin Action in Intestinal Cells J. Biol. Chem., October 2, 1998; 273(40): 26194 - 26201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bjorbak, R. M. Buchholz, S. M. Davis, S. H. Bates, D. D. Pierroz, H. Gu, B. G. Neel, M. G. Myers Jr., and J. S. Flier Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors J. Biol. Chem., February 9, 2001; 276(7): 4747 - 4755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Shanley, A. J. Irving, and J. Harvey Leptin Enhances NMDA Receptor Function and Modulates Hippocampal Synaptic Plasticity J. Neurosci., December 15, 2001; 21(24): RC186 - RC186. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
