|
|
|
|||||||
|
|||||||||
(Received for publication, April 7, 1997, and in revised form, April 30, 1997)
From the Glutathione peroxidase, a selenium-containing
enzyme, is believed to protect cells from the toxicity of
hydroperoxides. The physiological role of this enzyme has previously
been implicated mainly using animals fed with a selenium-deficient
diet. Although selenium deficiency also affects the activity of several
other cellular selenium-containing enzymes, a dramatic decrease of
glutathione peroxidase activity has been postulated to play a role in
the pathogenesis of a number of diseases, particularly those whose progression is associated with an overproduction of reactive oxygen species, found in selenium-deficient animals. To further clarify the
physiological relevance of this enzyme, a model of mice deficient in
cellular glutathione peroxidase (GSHPx-1), the major isoform of
glutathione peroxidase ubiquitously expressed in all types of cells,
was generated by gene-targeting technology. Mice deficient in this
enzyme were apparently healthy and fertile and showed no increased
sensitivity to hyperoxia. Their tissues exhibited neither a retarded
rate in consuming extracellular hydrogen peroxide nor an increased
content of protein carbonyl groups and lipid peroxidation compared with
those of wild-type mice. However, platelets from GSHPx-1-deficient mice
incubated with arachidonic acid generated less
12-hydroxyeicosatetraenoic acid and more polar products relative to
control platelets at a higher concentration of arachidonic acid,
presumably reflecting a decreased ability to reduce the 12-hydroperoxyeicosatetraenoic acid intermediate. These results suggest
that the contribution of GSHPx-1 to the cellular antioxidant mechanism
under normal animal development and physiological conditions and to the
pulmonary defense against hyperoxic insult is very limited.
Nevertheless, the potential antioxidant role of this enzyme in
protecting cells and animals against the pathogenic effect of reactive
oxygen species in other disorders remains to be defined. The knockout
mouse model described in this report will also provide a new tool for
future study to distinguish the physiological role of this enzyme from
other selenium-containing proteins in mammals under normal and disease
states.
Volume 272, Number 26,
Issue of June 27, 1997
pp. 16644-16651
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
,
,
,
,
,
and
Institute of Chemical Toxicology and
Department of Biochemistry, Wayne State University,
Detroit, Michigan 48201, the 
Department of Pathology, School
of Medicine, Tufts University, Boston, Massachusetts 02111, and the
Center for Experimental Therapeutics,
University of Pennsylvania, Philadelphia, Pennsylvania 19104
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K. M. Heyob, L. K. Rogers, and S. E. Welty Glutathione Reductase Targeted to Type II Cells Does Not Protect Mice from Hyperoxic Lung Injury Am. J. Respir. Cell Mol. Biol., December 1, 2008; 39(6): 683 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Yang, H.-Y. Qian, J. Huang, Y.-J. Geng, R.-L. Gao, K.-F. Dou, G.-S. Yang, J.-J. Li, R. Shen, Z.-X. He, et al. Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts Eur. Heart J., June 2, 2008; 29(12): 1578 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.-S. Han, F. L. Muller, V. I. Perez, W. Qi, H. Liang, L. Xi, C. Fu, E. Doyle, M. Hickey, J. Cornell, et al. The in vivo gene expression signature of oxidative stress Physiol Genomics, June 1, 2008; 34(1): 112 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Peters, N. Chatterjee, R. B. Hayes, R. E. Schoen, Y. Wang, S. J. Chanock, and C. B. Foster Variation in the Selenoenzyme Genes and Risk of Advanced Distal Colorectal Adenoma Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1144 - 1154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. T. Demchenko, D. N. Atochin, D. R. Gutsaeva, R. R. Godfrey, P. L. Huang, C. A. Piantadosi, and B. W. Allen Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects Am J Physiol Lung Cell Mol Physiol, May 1, 2008; 294(5): L984 - L990. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chrissobolis, S. P. Didion, D. A. Kinzenbaw, L. I. Schrader, S. Dayal, S. R. Lentz, and F. M. Faraci Glutathione Peroxidase-1 Plays a Major Role in Protecting Against Angiotensin II-Induced Vascular Dysfunction Hypertension, April 1, 2008; 51(4): 872 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. N. Stemm, J. C. Tharappel, H.-J. Lehmler, C. Srinivasan, J. S. Morris, V. L. Spate, L. W. Robertson, B. T. Spear, and H. P. Glauert Effect of Dietary Selenium on the Promotion of Hepatocarcinogenesis by 3,3', 4,4'-Tetrachlorobiphenyl and 2,2', 4,4', 5,5'-Hexachlorobiphenyl Experimental Biology and Medicine, March 1, 2008; 233(3): 366 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Shetty, F. L. Huang, and K.-P. Huang Ischemia-elicited Oxidative Modulation of Ca2+/Calmodulin-dependent Protein Kinase II J. Biol. Chem., February 29, 2008; 283(9): 5389 - 5401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Carlson, M. E. Moustafa, A. Sengupta, U. Schweizer, R. Shrimali, M. Rao, N. Zhong, S. Wang, L. Feigenbaum, B. J. Lee, et al. Selective Restoration of the Selenoprotein Population in a Mouse Hepatocyte Selenoproteinless Background with Different Mutant Selenocysteine tRNAs Lacking Um34 J. Biol. Chem., November 9, 2007; 282(45): 32591 - 32602. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Hulbert, R. Pamplona, R. Buffenstein, and W. A. Buttemer Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals Physiol Rev, October 1, 2007; 87(4): 1175 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Hoffmann, C. Jourdan-Le Saux, F. W. Hoffmann, P. S. Chang, O. Bollt, Q. He, E. K. Tam, and M. J. Berry A Role for Dietary Selenium and Selenoproteins in Allergic Airway Inflammation J. Immunol., September 1, 2007; 179(5): 3258 - 3267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Torzewski, V. Ochsenhirt, A. L. Kleschyov, M. Oelze, A. Daiber, H. Li, H. Rossmann, S. Tsimikas, K. Reifenberg, F. Cheng, et al. Deficiency of Glutathione Peroxidase-1 Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice Arterioscler. Thromb. Vasc. Biol., April 1, 2007; 27(4): 850 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Zhu, X. Zhang, J. P. McClung, and X. G. Lei Impact of Cu,Zn-Superoxide Dismutase and Se-Dependent Glutathione Peroxidase-1 Knockouts on Acetaminophen-Induced Cell Death and Related Signaling in Murine Liver Experimental Biology and Medicine, December 1, 2006; 231(11): 1726 - 1732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Singh, T. Rangasamy, R. K. Thimmulappa, H. Lee, W. O. Osburn, R. Brigelius-Flohe, T. W. Kensler, M. Yamamoto, and S. Biswal Glutathione Peroxidase 2, the Major Cigarette Smoke-Inducible Isoform of GPX in Lungs, Is Regulated by Nrf2 Am. J. Respir. Cell Mol. Biol., December 1, 2006; 35(6): 639 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chambellan, P. J. Cruickshank, P. McKenzie, S. B. Cannady, K. Szabo, S. A. A. Comhair, and S. C. Erzurum Gene Expression Profile of Human Airway Epithelium Induced by Hyperoxia In Vivo Am. J. Respir. Cell Mol. Biol., October 1, 2006; 35(4): 424 - 435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Zhu and X. G. Lei Double Null of Selenium-Glutathione Peroxidase-1 and Copper, Zinc-Superoxide Dismutase Enhances Resistance of Mouse Primary Hepatocytes to Acetaminophen Toxicity. Experimental Biology and Medicine, May 1, 2006; 231(5): 545 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Matsushima, T. Ide, M. Yamato, H. Matsusaka, F. Hattori, M. Ikeuchi, T. Kubota, K. Sunagawa, Y. Hasegawa, T. Kurihara, et al. Overexpression of Mitochondrial Peroxiredoxin-3 Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice Circulation, April 11, 2006; 113(14): 1779 - 1786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, S. A. Phelan, Y. Manevich, S. I. Feinstein, and A. B. Fisher Transgenic Mice Overexpressing Peroxiredoxin 6 Show Increased Resistance to Lung Injury in Hyperoxia Am. J. Respir. Cell Mol. Biol., April 1, 2006; 34(4): 481 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Haendeler and S. Dimmeler Inseparably Tied: Functional and Antioxidative Capacity of Endothelial Progenitor Cells Circ. Res., February 3, 2006; 98(2): 157 - 158. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Banning, S. Deubel, D. Kluth, Z. Zhou, and R. Brigelius-Flohe The GI-GPx Gene Is a Target for Nrf2 Mol. Cell. Biol., June 15, 2005; 25(12): 4914 - 4923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Diwadkar-Navsariwala and A. M. Diamond The Link between Selenium and Chemoprevention: A Case for Selenoproteins J. Nutr., November 1, 2004; 134(11): 2899 - 2902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Shefer, M. Wleklinski-Lee, and Z. Yablonka-Reuveni Skeletal muscle satellite cells can spontaneously enter an alternative mesenchymal pathway J. Cell Sci., October 15, 2004; 117(22): 5393 - 5404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-S. Chang, C.-S. Cho, S. Park, S. Yu, S. W. Kang, and S. G. Rhee Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria J. Biol. Chem., October 1, 2004; 279(40): 41975 - 41984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. V. Zubkova and B. Robaire Effect of Glutathione Depletion on Antioxidant Enzymes in the Epididymis, Seminal Vesicles, and Liver and on Spermatozoa Motility in the Aging Brown Norway Rat Biol Reprod, September 1, 2004; 71(3): 1002 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-S. Ho, Y. Xiong, W. Ma, A. Spector, and D. S. Ho Mice Lacking Catalase Develop Normally but Show Differential Sensitivity to Oxidant Tissue Injury J. Biol. Chem., July 30, 2004; 279(31): 32804 - 32812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, Y. Manevich, S. I. Feinstein, and A. B. Fisher Adenovirus-mediated transfer of the 1-cys peroxiredoxin gene to mouse lung protects against hyperoxic injury Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1188 - L1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Schweizer, L. Schomburg, and N. E. Savaskan The Neurobiology of Selenium: Lessons from Transgenic Mice J. Nutr., April 1, 2004; 134(4): 707 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shiomi, H. Tsutsui, H. Matsusaka, K. Murakami, S. Hayashidani, M. Ikeuchi, J. Wen, T. Kubota, H. Utsumi, and A. Takeshita Overexpression of Glutathione Peroxidase Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice Circulation, February 3, 2004; 109(4): 544 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cao, Y. Leng, W. Huang, X. Liu, and D. Kufe Glutathione Peroxidase 1 Is Regulated by the c-Abl and Arg Tyrosine Kinases J. Biol. Chem., October 10, 2003; 278(41): 39609 - 39614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Henderson and C. R. Wolf Transgenic Analysis of Human Drug-Metabolizing Enzymes: Preclinical Drug Development and Toxicology Mol. Interv., September 1, 2003; 3(6): 331 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-S. Kim, Y. Manevich, S. I. Feinstein, J. H. Pak, Y. S. Ho, and A. B. Fisher Induction of 1-cys peroxiredoxin expression by oxidative stress in lung epithelial cells Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L363 - L369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T.-H. Lee, S.-U. Kim, S.-L. Yu, S. H. Kim, D. S. Park, H.-B. Moon, S. H. Dho, K.-S. Kwon, H. J. Kwon, Y.-H. Han, et al. Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice Blood, June 15, 2003; 101(12): 5033 - 5038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Burk, K. E. Hill, and A. K. Motley Selenoprotein Metabolism and Function: Evidence for More than One Function for Selenoprotein P J. Nutr., May 1, 2003; 133(5): 1517S - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-S. Ho Transgenic and Knockout Models for Studying the Role of Lung Antioxidant Enzymes in Defense against Hyperoxia Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): S51 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dayal, K. L. Brown, C. J. Weydert, L. W. Oberley, E. Arning, T. Bottiglieri, F. M. Faraci, and S. R. Lentz Deficiency of Glutathione Peroxidase-1 Sensitizes Hyperhomocysteinemic Mice to Endothelial Dysfunction Arterioscler. Thromb. Vasc. Biol., December 1, 2002; 22(12): 1996 - 2002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Knight, Y.-S. Ho, A. Farhood, and H. Jaeschke Peroxynitrite Is a Critical Mediator of Acetaminophen Hepatotoxicity in Murine Livers: Protection by Glutathione J. Pharmacol. Exp. Ther., November 1, 2002; 303(2): 468 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Cudkowicz, K. A. Pastusza, P. C. Sapp, R. K. Mathews, J. Leahy, P. Pasinelli, J. W. Francis, D. Jiang, J. K. Andersen, and R. H. Brown Jr. Survival in transgenic ALS mice does not vary with CNS glutathione peroxidase activity Neurology, September 10, 2002; 59(5): 729 - 734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Johnson, G. Goyette Jr, Y. Ravindranath, and Y.-S. Ho Oxidation of glutathione peroxidase-deficient red cells by organic peroxides Blood, July 30, 2002; 100(4): 1515 - 1516. [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Cho, A. E. Jedlicka, S. P. M. Reddy, T. W. Kensler, M. Yamamoto, L.-Y. Zhang, and S. R. Kleeberger Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice Am. J. Respir. Cell Mol. Biol., February 1, 2002; 26(2): 175 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-T. King, C.-S. Lin, J.-H. Lin, and W.-C. Lee Whole-body hyperthermia-induced thermotolerance is associated with the induction of Heat Shock Protein 70 in mice J. Exp. Biol., January 15, 2002; 205(2): 273 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. N. Reddy, F. J. Giblin, L.-R. Lin, L. Dang, N. J. Unakar, D. C. Musch, D. L. Boyle, L. J. Takemoto, Y.-S. Ho, T. Knoernschild, et al. Glutathione Peroxidase-1 Deficiency Leads to Increased Nuclear Light Scattering, Membrane Damage, and Cataract Formation in Gene-Knockout Mice Invest. Ophthalmol. Vis. Sci., December 1, 2001; 42(13): 3247 - 3255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fu, H. Sies, and X. G. Lei Opposite Roles of Selenium-dependent Glutathione Peroxidase-1 in Superoxide Generator Diquat- and Peroxynitrite-induced Apoptosis and Signaling J. Biol. Chem., November 9, 2001; 276(46): 43004 - 43009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ghose, J. Fleming, K. El-Bayoumy, and P. R. Harrison Enhanced Sensitivity of Human Oral Carcinomas to Induction of Apoptosis by Selenium Compounds: Involvement of Mitogen-activated Protein Kinase and Fas Pathways Cancer Res., October 1, 2001; 61(20): 7479 - 7487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Esworthy, R. Aranda, M. G. Martin, J. H. Doroshow, S. W. Binder, and F.-F. Chu Mice with combined disruption of Gpx1 and Gpx2 genes have colitis Am J Physiol Gastrointest Liver Physiol, September 1, 2001; 281(3): G848 - G855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Van Remmen, M. D. Williams, Z. Guo, L. Estlack, H. Yang, E. J. Carlson, C. J. Epstein, T. T. Huang, and A. Richardson Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1422 - H1432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Guo, H. Van Remmen, H. Yang, X. Chen, J. Mele, J. Vijg, C. J. Epstein, Y.-S. Ho, and A. Richardson Changes in Expression of Antioxidant Enzymes Affect Cell-Mediated LDL Oxidation and Oxidized LDL-Induced Apoptosis in Mouse Aortic Cells Arterioscler. Thromb. Vasc. Biol., July 1, 2001; 21(7): 1131 - 1138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Copeland, V. A. Stepanik, and D. M. Driscoll Insight into Mammalian Selenocysteine Insertion: Domain Structure and Ribosome Binding Properties of Sec Insertion Sequence Binding Protein 2 Mol. Cell. Biol., March 1, 2001; 21(5): 1491 - 1498. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. BARSYTE, D. A. LOVEJOY, and G. J. LITHGOW Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans FASEB J, March 1, 2001; 15(3): 627 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Johnson, G. Goyette Jr, Y. Ravindranath, and Y.-S. Ho Red cells from glutathione peroxidase-1-deficient mice have nearly normal defenses against exogenous peroxides Blood, September 1, 2000; 96(5): 1985 - 1988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Esworthy, J. R. Mann, M. Sam, and F.-F. Chu Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma -irradiation damage Am J Physiol Gastrointest Liver Physiol, August 1, 2000; 279(2): G426 - G436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Klivenyi, O. A. Andreassen, R. J. Ferrante, A. Dedeoglu, G. Mueller, E. Lancelot, M. Bogdanov, J. K. Andersen, D. Jiang, and M. F. Beal Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine J. Neurosci., January 1, 2000; 20(1): 1 - 7. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. K. Fukagawa Aging: Is Oxidative Stress a Marker or Is It Causal? Experimental Biology and Medicine, December 1, 1999; 222(3): 293 - 298. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Fu, W.-H. Cheng, D. A. Ross, and X. g. Lei Cellular Glutathione Peroxidase Protects Mice Against Lethal Oxidative Stress Induced by Various Doses of Diquat Experimental Biology and Medicine, November 1, 1999; 222(2): 164 - 169. [Abstract] [Full Text]
|
|
|
|
|
|
W.-H. Cheng, B. A. Valentine, and X. G. Lei High Levels of Dietary Vitamin E Do Not Replace Cellular Glutathione Peroxidase in Protecting Mice from Acute Oxidative Stress J. Nutr., November 1, 1999; 129(11): 1951 - 1957. [Abstract] [Full Text]
|
|
|
|
|
|
J. R. Gasdaska, J. W. Harney, P. Y. Gasdaska, G. Powis, and M. J. Berry Regulation of Human Thioredoxin Reductase Expression and Activity by 3'-Untranslated Region Selenocysteine Insertion Sequence and mRNA Instability Elements J. Biol. Chem., September 3, 1999; 274(36): 25379 - 25385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-H. CHENG, Y. X. FU, J. M. PORRES, D. A. ROSS, and X. G. LEI Selenium-dependent cellular glutathione peroxidase protects mice against a pro-oxidant-induced oxidation of NADPH, NADH, lipids, and protein FASEB J, August 1, 1999; 13(11): 1467 - 1475. [Abstract] [Full Text]
|
|
|
|
|
|
C. Buettner, J. W. Harney, and M. J. Berry The Caenorhabditis elegans Homologue of Thioredoxin Reductase Contains a Selenocysteine Insertion Sequence (SECIS) Element That Differs from Mammalian SECIS Elements but Directs Selenocysteine Incorporation J. Biol. Chem., July 30, 1999; 274(31): 21598 - 21602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Singh and H. Shichi A Novel Glutathione Peroxidase in Bovine Eye. SEQUENCE ANALYSIS, mRNA LEVEL, AND TRANSLATION J. Biol. Chem., October 2, 1998; 273(40): 26171 - 26178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Beck, R. S. Esworthy, Y. Ho, and F. Chu Glutathione peroxidase protects mice from viral-induced myocarditis FASEB J, September 1, 1998; 12(12): 1143 - 1149. [Abstract] [Full Text]
|
|
|
|
|
|
J. B. de Haan, C. Bladier, P. Griffiths, M. Kelner, R. D. O'Shea, N. S. Cheung, R. T. Bronson, M. J. Silvestro, S. Wild, S. S. Zheng, et al. Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide J. Biol. Chem., August 28, 1998; 273(35): 22528 - 22536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-H. Cheng, Y.-S. Ho, B. A. Valentine, D. A. Ross,, G. F. Combs Jr., and X. G. Lei Cellular Glutathione Peroxidase Is the Mediator of Body Selenium To Protect against Paraquat Lethality in Transgenic Mice J. Nutr., July 1, 1998; 128(7): 1070 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. BECKMAN and B. N. AMES The Free Radical Theory of Aging Matures Physiol Rev, April 1, 1998; 78(2): 547 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. N. Johnson, L. F. Brass, and C. D. Funk Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase PNAS, March 17, 1998; 95(6): 3100 - 3105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Beattie, A. M. Wood, A. M. Newman, I. Bremner, K. H. A. Choo, A. E. Michalska, J. S. Duncan, and P. Trayhurn Obesity and hyperleptinemia in metallothionein (-I and -II) null mice PNAS, January 6, 1998; 95(1): 358 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Forgione, N. Weiss, S. Heydrick, A. Cap, E. S. Klings, C. Bierl, R. T. Eberhardt, H. W. Farber, and J. Loscalzo Cellular glutathione peroxidase deficiency and endothelial dysfunction Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1255 - H1261. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |