JBC Transcription and Nuclear Factor Monoclonals

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wolberg, A. S.
Right arrow Articles by Erie, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wolberg, A. S.
Right arrow Articles by Erie, D. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Volume 272, Number 27, Issue of July 4, 1997 pp. 16717-16720
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

COMMUNICATION:
Human Factor IX Binds to Specific Sites on the Collagenous Domain of Collagen IV

(Received for publication, November 14, 1996, and in revised form, April 28, 1997)

Alisa S. Wolberg Dagger , Darrel W. Stafford Dagger and Dorothy A. Erie

From the Dagger  Department of Biology and Center for Thrombosis and Hemostasis and the  Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599

The primary region of factor IX that mediates binding to bovine aortic endothelial cells resides in residues 3-11 of the N-terminal region known as the Gla domain. Recently, it was proposed that the observed binding to endothelial cells is actually a measure of the interaction between factor IX and collagen IV (Cheung, W. F., van den Born, J., Kuhn, K., Kjellen, L., Hudson, B. G., and Stafford, D. W. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 11068-11073). To confirm that factor IX binds to collagen IV and to examine the specificity of this interaction, we used scanning force microscopy to examine factor IX binding to collagen IV. We imaged collagen IV in the presence and the absence of factor IX and observed specific interactions between factor IX and collagen IV. Our results demonstrate that factor IX binds to collagen IV at specific sites in the collagenous domain ~98 and ~50 nm from the C-terminal pepsin-cleaved end.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
B.-G. Yang, T. Tanaka, M. H. Jang, Z. Bai, H. Hayasaka, and M. Miyasaka
Binding of Lymphoid Chemokines to Collagen IV That Accumulates in the Basal Lamina of High Endothelial Venules: Its Implications in Lymphocyte Trafficking
J. Immunol., October 1, 2007; 179(7): 4376 - 4382.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. E. Russell, E. H. N. Olsen, R. A. Raymer, E. P. Merricks, D. A. Bellinger, M. S. Read, B. J. Rup, J. C. Keith Jr, K. P. McCarthy, R. G. Schaub, et al.
Reduced bleeding events with subcutaneous administration of recombinant human factor IX in immune-tolerant hemophilia B dogs
Blood, December 15, 2003; 102(13): 4393 - 4398.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Aktimur, M. A. Gabriel, D. Gailani, and J. R. Toomey
The Factor IX gamma -Carboxyglutamic Acid (Gla) Domain Is Involved in Interactions between Factor IX and Factor XIa
J. Biol. Chem., February 28, 2003; 278(10): 7981 - 7987.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Gui, H.-F. Lin, D.-Y. Jin, M. Hoffman, D. L. Straight, H. R. Roberts, and D. W. Stafford
Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo
Blood, June 17, 2002; 100(1): 153 - 158.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1997 by the American Society for Biochemistry and Molecular Biology.