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, a Novel Phosphatidylinositol 3-Kinase Catalytic Subunit
That Associates with p85 and Is Expressed Predominantly in
Leukocytes
(Received for publication, January 23, 1997, and in revised form, May 20, 1997)
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From We have identified a novel p110 isoform of
phosphatidylinositol 3-kinase from human leukocytes that we have termed
p110 ICOS Corporation, Bothell, Washington 98021, § Department of Biological Chemistry, University of
Michigan, Ann Arbor, Michigan 48109, ¶ Fred Hutchinson Cancer
Research Center, Seattle, Washington 98104
. In addition, we have independently isolated p110 from a
mouse embryo library on the basis of its ability to interact with
Ha-RasV12 in the yeast two-hybrid system. This unique
isoform contains all of the conserved structural features
characteristic of the p110 family. Recombinant p110 phosphorylates
phosphatidylinositol and coimmunoprecipitates with p85. However, in
contrast to previously described p110 subunits, p110 is expressed in
a tissue-restricted fashion; it is expressed at high levels in
lymphocytes and lymphoid tissues and may therefore play a role in
phosphatidylinositol 3-kinase-mediated signaling in the immune
system.
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