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(Received for publication, February 3, 1997)
From the Cancer and Polio Research Fund Laboratories, School of
Biological Sciences, University of Liverpool, P. O. Box 147,
Liverpool L69 7ZB, United Kingdom
The S100-related calcium-binding protein S100A4
(p9Ka) is expressed at a low level in rat mammary epithelial cells from
normal mammary gland and benign mammary tumors. In transgenic mice,
expressed rat S100A4 transgenes co-operate with the activated
c-erbB-2 oncogene, neu, to form metastatic
mammary tumors. Elevated levels of S100A4 (p9Ka) in cultured benign rat
or mouse mammary epithelial cells are associated with the induction of
metastatic capability. A cis-acting sequence related to the
consensus recognition sequence of GC-factor, 1,300 base pairs upstream
of the start site of transcription of the rat S100A4 gene, acts as a
cis-acting inhibitor of transcription of the S100A4 (p9Ka)
gene in a low S100A4 (p9Ka)-expressing benign rat mammary epithelial
cell line, but not in highly expressing rat mammary epithelial cell
lines. There is an inverse relationship between the level of S100A4
(p9Ka) mRNA and the level of GC-factor mRNA in a range of rat
mammary cell lines. The results suggest a novel mechanism for
regulating the expression of the mRNA encoding an S100 protein.
Volume 272, Number 32,
Issue of August 8, 1997
pp. 20283-20290
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
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