| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, April 18, 1997, and in revised form, June 11, 1997)
From the Department of Chemistry and Biochemistry, School of
Medicine and Revelle College, University of California at San
Diego, La Jolla, California 92093-0601
Ceramide has emerged as an important lipid
messenger for many cellular processes triggered via surface receptors.
In the present study, inflammatory activation of
P388D1 macrophages with bacterial lipopolysaccharide
(LPS) and platelet-activating factor (PAF) stimulated a transient
accumulation of ceramide. Moreover, cell-permeable ceramide mimicked
LPS/PAF in triggering arachidonate mobilization in these cells.
LPS/PAF-induced ceramide synthesis did not result from sphingomyelinase
activation but from increased de novo synthesis. Participation of this pathway in arachidonate signaling was detected since fumonisin B1, an inhibitor of de novo
ceramide synthesis, was able to inhibit the LPS/PAF-induced response.
These studies have uncovered a new role for sphingolipid metabolism in
cellular signaling and constitute evidence that products of the
sphingomyelin biosynthetic pathway may serve a specific role in signal
transduction by influencing the activity of the novel Group V secretory
phospholipase A2.
Volume 272, Number 33,
Issue of August 15, 1997
pp. 20373-20377
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Uhlig and E. Gulbins Sphingolipids in the Lungs Am. J. Respir. Crit. Care Med., December 1, 2008; 178(11): 1100 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Pindado, J. Balsinde, and M. A. Balboa TLR3-Dependent Induction of Nitric Oxide Synthase in RAW 264.7 Macrophage-Like Cells via a Cytosolic Phospholipase A2/Cyclooxygenase-2 Pathway J. Immunol., October 1, 2007; 179(7): 4821 - 4828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Ruiperez, J. Casas, M. A. Balboa, and J. Balsinde Group V Phospholipase A2-Derived Lysophosphatidylcholine Mediates Cyclooxygenase-2 Induction in Lipopolysaccharide-Stimulated Macrophages J. Immunol., July 1, 2007; 179(1): 631 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Singh and P. V. Subbaiah Modulation of the activity and arachidonic acid selectivity of group X secretory phospholipase A2 by sphingolipids J. Lipid Res., March 1, 2007; 48(3): 683 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Saavedra, W. Zhang, B. Peterson, and B. S. Cummings Differential Roles for Cytosolic and Microsomal Ca2+-Independent Phospholipase A2 in Cell Growth and Maintenance of Phospholipids J. Pharmacol. Exp. Ther., September 1, 2006; 318(3): 1211 - 1219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Balboa, R. Perez, and J. Balsinde Amplification Mechanisms of Inflammation: Paracrine Stimulation of Arachidonic Acid Mobilization by Secreted Phospholipase A2 Is Regulated by Cytosolic Phospholipase A2-Derived Hydroperoxyeicosatetraenoic Acid J. Immunol., July 15, 2003; 171(2): 989 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Balboa and J. Balsinde Involvement of Calcium-independent Phospholipase A2 in Hydrogen Peroxide-induced Accumulation of Free Fatty Acids in Human U937 Cells J. Biol. Chem., October 18, 2002; 277(43): 40384 - 40389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. O. Gronroos, V. J. O. Laine, M. J. W. Janssen, M. R. Egmond, and T. J. Nevalainen Bactericidal Properties of Group IIA and Group V Phospholipases A2 J. Immunol., March 15, 2001; 166(6): 4029 - 4034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kuwata, S. Yamamoto, Y. Miyazaki, S. Shimbara, Y. Nakatani, H. Suzuki, N. Ueda, S. Yamamoto, M. Murakami, and I. Kudo Studies on a Mechanism by Which Cytosolic Phospholipase A2 Regulates the Expression and Function of Type IIA Secretory Phospholipase A2 J. Immunol., October 1, 2000; 165(7): 4024 - 4031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, T. Kambe, S. Shimbara, K.-i. Higashino, K. Hanasaki, H. Arita, M. Horiguchi, M. Arita, H. Arai, K. Inoue, et al. Different Functional Aspects of the Group II Subfamily (Types IIA and V) and Type X Secretory Phospholipase A2s in Regulating Arachidonic Acid Release and Prostaglandin Generation. IMPLICATIONS OF CYCLOOXYGENASE-2 INDUCTION AND PHOSPHOLIPID SCRAMBLASE-MEDIATED CELLULAR MEMBRANE PERTURBATION J. Biol. Chem., October 29, 1999; 274(44): 31435 - 31444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Balsinde, M. A. Balboa, and E. A. Dennis Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A2 PNAS, July 7, 1998; 95(14): 7951 - 7956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, S. Shimbara, T. Kambe, H. Kuwata, M. V. Winstead, J. A. Tischfield, and I. Kudo The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release. TYPE IIA AND TYPE V SECRETORY PHOSPHOLIPASE A2S ARE FUNCTIONALLY REDUNDANT AND ACT IN CONCERT WITH CYTOSOLIC PHOSPHOLIPASE A2 J. Biol. Chem., June 5, 1998; 273(23): 14411 - 14423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Wells, R. C. Dickson, and R. L. Lester Heat-induced Elevation of Ceramide in Saccharomyces cerevisiae via de Novo Synthesis J. Biol. Chem., March 27, 1998; 273(13): 7235 - 7243. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
