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(Received for publication, May 2, 1997, and in revised form, June 6, 1997)
From the Institut de Pharmacologie Moléculaire et
Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
We have cloned and expressed a novel proton-gated
Na+ channel subunit that is specific for sensory
neurons. In COS cells, it forms a Na+ channel that responds
to a drop of the extracellular pH with both a rapidly inactivating and
a sustained Na+ current. This biphasic kinetic closely
resembles that of the H+-gated current described in sensory
neurons of dorsal root ganglia (1). Both the abundance of this novel
H+-gated Na+ channel subunit in sensory neurons
and the kinetics of the channel suggest that it is part of the channel
complex responsible for the sustained H+-activated cation
current in sensory neurons that is thought to be important for the
prolonged perception of pain that accompanies tissue acidosis (1, 2).
Volume 272, Number 34,
Issue of August 22, 1997
pp. 20975-20978
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
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