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(Received for publication, January 9, 1997, and in revised form, May 21, 1997)
From the Georgetown University Medical Center, Department of
Pharmacology and the Lombardi Cancer Center,
Washington, D.C. 20007
Transcription factor Sp1 is a phosphoprotein
whose level and DNA binding activity are markedly increased in
doxorubicin-resistant HL-60 (HL-60/AR) leukemia cells. The
trans-activating and DNA binding properties of Sp1 in
HL-60/AR cells are stimulated by cAMP-dependent protein
kinase (PKA) and PKA agonists and inhibited by PKA antagonists as well
as by the PKA regulatory subunit. Reporter gene activity under the
control of the Sp1-dependent SV40 promoter is stimulated in
insect cells transiently expressing Sp1 and PKA, and the DNA binding
activity of recombinant Sp1 is activated by exogenous PKA in
vitro. These results indicate that Sp1 is a cAMP-responsive transcription factor and that Sp1-dependent genes may be
modulated through a cAMP-dependent signaling pathway.
Volume 272, Number 34,
Issue of August 22, 1997
pp. 21137-21141
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
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K. Yamada, T. Tanaka, K. Miyamoto, and T. Noguchi Sp Family Members and Nuclear Factor-Y Cooperatively Stimulate Transcription from the Rat Pyruvate Kinase M Gene Distal Promoter Region via Their Direct Interactions J. Biol. Chem., June 9, 2000; 275(24): 18129 - 18137. [Abstract] [Full Text] [PDF]
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S. Horie, H. Ishii, F. Matsumoto, M. Kusano, K. Kizaki, J. Matsuda, and M. Kazama Acceleration of Thrombomodulin Gene Transcription by Retinoic Acid. RETINOIC ACID RECEPTORS AND Sp1 REGULATE THE PROMOTER ACTIVITY THROUGH INTERACTIONS WITH TWO DIFFERENT SEQUENCES IN THE 5'-FLANKING REGION OF HUMAN GENE J. Biol. Chem., January 19, 2001; 276(4): 2440 - 2450. [Abstract] [Full Text] [PDF]
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A.-C. Poncelet and H. W. Schnaper Sp1 and Smad Proteins Cooperate to Mediate Transforming Growth Factor-beta 1-induced alpha 2(I) Collagen Expression in Human Glomerular Mesangial Cells J. Biol. Chem., March 2, 2001; 276(10): 6983 - 6992. [Abstract] [Full Text] [PDF]
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Y. Yang, C. K. Hwang, E. Junn, G. Lee, and M. M. Mouradian ZIC2 and Sp3 Repress Sp1-induced Activation of the Human D1ADopamine Receptor Gene J. Biol. Chem., December 1, 2000; 275(49): 38863 - 38869. [Abstract] [Full Text] [PDF]
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K.-Y. Kim, T. Rhim, I. Choi, and S.-S. Kim N-Acetylcysteine Induces Cell Cycle Arrest in Hepatic Stellate Cells through Its Reducing Activity J. Biol. Chem., October 26, 2001; 276(44): 40591 - 40598. [Abstract] [Full Text] [PDF]
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T. Fukada and N. K. Tonks The Reciprocal Role of Egr-1 and Sp Family Proteins in Regulation of the PTP1B Promoter in Response to the p210 Bcr-Abl Oncoprotein-tyrosine Kinase J. Biol. Chem., June 29, 2001; 276(27): 25512 - 25519. [Abstract] [Full Text] [PDF]
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D. N. Douglas, V. W. Dolinsky, R. Lehner, and D. E. Vance A Role for Sp1 in the Transcriptional Regulation of Hepatic Triacylglycerol Hydrolase in the Mouse J. Biol. Chem., June 29, 2001; 276(27): 25621 - 25630. [Abstract] [Full Text] [PDF]
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H. Sellak, X. Yang, X. Cao, T. Cornwell, G. A. Soff, and T. Lincoln Sp1 Transcription Factor as a Molecular Target for Nitric Oxide- and Cyclic Nucleotide-Mediated Suppression of cGMP-Dependent Protein Kinase-I{alpha} Expression in Vascular Smooth Muscle Cells Circ. Res., March 8, 2002; 90(4): 405 - 412. [Abstract] [Full Text] [PDF]
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