| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, March 25, 1997)
From the Department of Inflammation Research, Merck Research
Laboratories, Rahway, New Jersey 07065
Following interleukin (IL)-1 stimulation, the
majority of the cellular interleukin-1 receptor-associated kinase
(IRAK) translocates to a discrete subset of the Type I IL-1 receptor
(IL-1R1) in MRC-5 human lung fibroblasts. As the IRAK becomes
multiphosphorylated, it is degraded by proteasomes at a rate comparable
to that of the degradation of the phosphorylated I
Volume 272, Number 34,
Issue of August 22, 1997
pp. 21540-21547
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
B
protein.
Proteasome inhibitors block the degradation of phosphorylated IRAK and
correspondingly increase the amount of IL-1R1 that can be
coimmunoprecipitated with IRAK. The nonspecific kinase inhibitor K-252b
blocks IRAK phosphorylation and degradation, but does not inhibit IRAK
association with the IL-1R1 indicating that translocation of IRAK to
the IL-1R1 and its phosphorylation are independent events. The IL-1
specificity of these effects is indicated by the lack of IRAK
phosphorylation and degradation by IL-1 in the presence of the IL-1
receptor antagonist or by the activation of MRC-5 cells by tumor
necrosis factor . Long term exposure of MRC-5 cells to IL-1
desensitizes the resynthesized IB to IL-1, but not to tumor
necrosis factor stimulation, but no additional effects on IRAK are
seen.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Lockett, M. G. Goebl, and M. A. Harrington Transient membrane recruitment of IRAK-1 in response to LPS and IL-1{beta} requires TNF R1 Am J Physiol Cell Physiol, August 1, 2008; 295(2): C313 - C323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Liu, Y.-J. Park, and E. Abraham Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-{kappa}B activation requires cytosolic and nuclear activity FASEB J, July 1, 2008; 22(7): 2285 - 2296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Xiao, W. Qian, K. Staschke, Y. Qian, G. Cui, L. Deng, M. Ehsani, X. Wang, Y.-W. Qian, Z. J. Chen, et al. Pellino 3b Negatively Regulates Interleukin-1-induced TAK1-dependent NF{kappa}B Activation J. Biol. Chem., May 23, 2008; 283(21): 14654 - 14664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Conze, C.-J. Wu, J. A. Thomas, A. Landstrom, and J. D. Ashwell Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-{kappa}B Activation Mol. Cell. Biol., May 15, 2008; 28(10): 3538 - 3547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Perry, S. A. Moschos, A. E. Williams, N. J. Shepherd, H. M. Larner-Svensson, and M. A. Lindsay Rapid Changes in MicroRNA-146a Expression Negatively Regulate the IL-1{beta}-Induced Inflammatory Response in Human Lung Alveolar Epithelial Cells J. Immunol., April 15, 2008; 180(8): 5689 - 5698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Windheim, M. Stafford, M. Peggie, and P. Cohen Interleukin-1 (IL-1) Induces the Lys63-Linked Polyubiquitination of IL-1 Receptor-Associated Kinase 1 To Facilitate NEMO Binding and the Activation of I{kappa}B{alpha} Kinase Mol. Cell. Biol., March 1, 2008; 28(5): 1783 - 1791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kubo-Murai, K. Hazeki, K. Nigorikawa, T. Omoto, N. Inoue, and O. Hazeki IRAK-4-dependent Degradation of IRAK-1 is a Negative Feedback Signal for TLR-mediated NF-{kappa}B Activation J. Biochem., March 1, 2008; 143(3): 295 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Rutkute, R. H. Asmis, and M. N. Nikolova-Karakashian Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation J. Lipid Res., November 1, 2007; 48(11): 2443 - 2452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zhande, S. M. Dauphinee, J. A. Thomas, M. Yamamoto, S. Akira, and A. Karsan FADD Negatively Regulates Lipopolysaccharide Signaling by Impairing Interleukin-1 Receptor-Associated Kinase 1-MyD88 Interaction Mol. Cell. Biol., November 1, 2007; 27(21): 7394 - 7404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Brikos, R. Wait, S. Begum, L. A. J. O'Neill, and J. Saklatvala Mass Spectrometric Analysis of the Endogenous Type I Interleukin-1 (IL-1) Receptor Signaling Complex Formed after IL-1 Binding Identifies IL-1RAcP, MyD88, and IRAK-4 as the Stable Components Mol. Cell. Proteomics, September 1, 2007; 6(9): 1551 - 1559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Koziczak-Holbro, C. Joyce, A. Gluck, B. Kinzel, M. Muller, C. Tschopp, J. C. Mathison, C. N. Davis, and H. Gram IRAK-4 Kinase Activity Is Required for Interleukin-1 (IL-1) Receptor- and Toll-like Receptor 7-mediated Signaling and Gene Expression J. Biol. Chem., May 4, 2007; 282(18): 13552 - 13560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yao, T. W. Kim, J. Qin, Z. Jiang, Y. Qian, H. Xiao, Y. Lu, W. Qian, M. F. Gulen, N. Sizemore, et al. Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NF{kappa}B Activation Pathways Bifurcate at IL-1 Receptor-associated Kinase Modification J. Biol. Chem., March 2, 2007; 282(9): 6075 - 6089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Y. Zhang and R. A. Daynes Glucocorticoid Conditioning of Myeloid Progenitors Enhances TLR4 Signaling via Negative Regulation of the Phosphatidylinositol 3-Kinase-Akt Pathway J. Immunol., February 15, 2007; 178(4): 2517 - 2526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hacker and M. Karin Regulation and Function of IKK and IKK-Related Kinases Sci. Signal., October 17, 2006; 2006(357): re13 - re13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Qin, J. Yao, G. Cui, H. Xiao, T. W. Kim, J. Fraczek, P. Wightman, S. Sato, S. Akira, A. Puel, et al. TLR8-mediated NF-{kappa}B and JNK Activation Are TAK1-independent and MEKK3-dependent J. Biol. Chem., July 28, 2006; 281(30): 21013 - 21021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Lasker and S. K. Nair Intracellular TLR Signaling: A Structural Perspective on Human Disease J. Immunol., July 1, 2006; 177(1): 11 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Medvedev, I. Sabroe, J. D. Hasday, and S. N. Vogel Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease Innate Immunity, June 1, 2006; 12(3): 133 - 150. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Lotz, D. Gutle, S. Walther, S. Menard, C. Bogdan, and M. W. Hornef Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells J. Exp. Med., April 17, 2006; 203(4): 973 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Z. Q. Wang, N. Wara-Aswapati, J. A. Boch, Y. Yoshida, C.-D. Hu, D. L. Galson, and P. E. Auron TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src J. Cell Sci., April 15, 2006; 119(8): 1579 - 1591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. H. Li, J. H. Wang, and H. P. Redmond Bacterial lipoprotein-induced self-tolerance and cross-tolerance to LPS are associated with reduced IRAK-1 expression and MyD88-IRAK complex formation J. Leukoc. Biol., April 1, 2006; 79(4): 867 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hirata, T. Ohmae, W. Shibata, S. Maeda, K. Ogura, H. Yoshida, T. Kawabe, and M. Omata MyD88 and TNF Receptor-Associated Factor 6 Are Critical Signal Transducers in Helicobacter pylori-Infected Human Epithelial Cells J. Immunol., March 15, 2006; 176(6): 3796 - 3803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Didierlaurent, B. Brissoni, D. Velin, N. Aebi, A. Tardivel, E. Kaslin, J. C. Sirard, G. Angelov, J. Tschopp, and K. Burns Tollip Regulates Proinflammatory Responses to Interleukin-1 and Lipopolysaccharide Mol. Cell. Biol., February 1, 2006; 26(3): 735 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Wang, T.-H. Chuang, T. Ronni, S. Gu, Y.-C. Du, H. Cai, H.-Q. Sun, H. L. Yin, and X. Chen Flightless I Homolog Negatively Modulates the TLR Pathway J. Immunol., February 1, 2006; 176(3): 1355 - 1362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dunne and L. O'Neill New insights into the post-translational modification of Toll-like receptor signaling molecules Innate Immunity, December 1, 2005; 11(6): 325 - 332. [Abstract] [PDF]
|
|
|
|
|
|
T. P. Carroll, C. M. Greene, C. C. Taggart, A. G. Bowie, S. J. O'Neill, and N. G. McElvaney Viral Inhibition of IL-1- and Neutrophil Elastase-Induced Inflammatory Responses in Bronchial Epithelial Cells J. Immunol., December 1, 2005; 175(11): 7594 - 7601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ohnuma, T. Yamochi, M. Uchiyama, K. Nishibashi, S. Iwata, O. Hosono, H. Kawasaki, H. Tanaka, N. H. Dang, and C. Morimoto CD26 Mediates Dissociation of Tollip and IRAK-1 from Caveolin-1 and Induces Upregulation of CD86 on Antigen-Presenting Cells Mol. Cell. Biol., September 1, 2005; 25(17): 7743 - 7757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Pruett, Q. Zheng, C. Schwab, and R. Fan Sodium Methyldithiocarbamate Inhibits MAP Kinase Activation through Toll-like Receptor 4, Alters Cytokine Production by Mouse Peritoneal Macrophages, and Suppresses Innate Immunity Toxicol. Sci., September 1, 2005; 87(1): 75 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Rao, S. Nguyen, K. Ngo, and W.-P. Fung-Leung A Novel Splice Variant of Interleukin-1 Receptor (IL-1R)-Associated Kinase 1 Plays a Negative Regulatory Role in Toll/IL-1R-Induced Inflammatory Signaling Mol. Cell. Biol., August 1, 2005; 25(15): 6521 - 6532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chao, Y. Shen, X. Zhu, H. Zhao, M. Novikov, U. Schmidt, and A. Rosenzweig Lipopolysaccharide Improves Cardiomyocyte Survival and Function after Serum Deprivation J. Biol. Chem., June 10, 2005; 280(23): 21997 - 22005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Medvedev, K. Thomas, A. Awomoyi, D. B. Kuhns, J. I. Gallin, X. Li, and S. N. Vogel Cutting Edge: Expression of IL-1 Receptor-Associated Kinase-4 (IRAK-4) Proteins with Mutations Identified in a Patient with Recurrent Bacterial Infections Alters Normal IRAK-4 Interaction with Components of the IL-1 Receptor Complex J. Immunol., June 1, 2005; 174(11): 6587 - 6591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zeyda, M. D. Saemann, K. M. Stuhlmeier, D. G. Mascher, P. N. Nowotny, G. J. Zlabinger, W. Waldhausl, and T. M. Stulnig Polyunsaturated Fatty Acids Block Dendritic Cell Activation and Function Independently of NF-{kappa}B Activation J. Biol. Chem., April 8, 2005; 280(14): 14293 - 14301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Storling, N. Allaman-Pillet, A. E. Karlsen, N. Billestrup, C. Bonny, and T. Mandrup-Poulsen Antitumorigenic Effect of Proteasome Inhibitors on Insulinoma Cells Endocrinology, April 1, 2005; 146(4): 1718 - 1726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. De Nardo, P. Masendycz, S. Ho, M. Cross, A. J. Fleetwood, E. C. Reynolds, J. A. Hamilton, and G. M. Scholz A Central Role for the Hsp90{middle dot}Cdc37 Molecular Chaperone Module in Interleukin-1 Receptor-associated-kinase-dependent Signaling by Toll-like Receptors J. Biol. Chem., March 18, 2005; 280(11): 9813 - 9822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Huang, T. Li, D. C. Sane, and L. Li IRAK1 Serves as a Novel Regulator Essential for Lipopolysaccharide-induced Interleukin-10 Gene Expression J. Biol. Chem., December 3, 2004; 279(49): 51697 - 51703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hatao, M. Muroi, N. Hiki, T. Ogawa, Y. Mimura, M. Kaminishi, and K.-i. Tanamoto Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein J. Leukoc. Biol., October 1, 2004; 76(4): 904 - 908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Noubir, Z. Hmama, and N. E. Reiner Dual Receptors and Distinct Pathways Mediate Interleukin-1 Receptor-associated Kinase Degradation in Response to Lipopolysaccharide: INVOLVEMENT OF CD14/TLR4, CR3, AND PHOSPHATIDYLINOSITOL 3-KINASE J. Biol. Chem., June 11, 2004; 279(24): 25189 - 25195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Wheeler, J. D. Catravas, K. Odoms, A. Denenberg, V. Malhotra, and H. R. Wong Epigallocatechin-3-gallate, a Green Tea-Derived Polyphenol, Inhibits IL-1{beta}-Dependent Proinflammatory Signal Transduction in Cultured Respiratory Epithelial Cells J. Nutr., May 1, 2004; 134(5): 1039 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Hongkuan Fan and J. A. Cook Review: Molecular mechanisms of endotoxin tolerance Innate Immunity, April 1, 2004; 10(2): 71 - 84. [Abstract] [PDF]
|
|
|
|
|
|
C. Kollewe, A.-C. Mackensen, D. Neumann, J. Knop, P. Cao, S. Li, H. Wesche, and M. U. Martin Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling J. Biol. Chem., February 13, 2004; 279(7): 5227 - 5236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Radons, S. Dove, D. Neumann, R. Altmann, A. Botzki, M. U. Martin, and W. Falk The Interleukin 1 (IL-1) Receptor Accessory Protein Toll/IL-1 Receptor Domain: ANALYSIS OF PUTATIVE INTERACTION SITES BY IN VITRO MUTAGENESIS AND MOLECULAR MODELING J. Biol. Chem., December 5, 2003; 278(49): 49145 - 49153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Haase, C. J. Kirschning, A. Sing, P. Schrottner, K. Fukase, S. Kusumoto, H. Wagner, J. Heesemann, and K. Ruckdeschel A Dominant Role of Toll-Like Receptor 4 in the Signaling of Apoptosis in Bacteria-Faced Macrophages J. Immunol., October 15, 2003; 171(8): 4294 - 4303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Medvedev, A. Lentschat, D. B. Kuhns, J. C.G. Blanco, C. Salkowski, S. Zhang, M. Arditi, J. I. Gallin, and S. N. Vogel Distinct Mutations in IRAK-4 Confer Hyporesponsiveness to Lipopolysaccharide and Interleukin-1 in a Patient with Recurrent Bacterial Infections J. Exp. Med., August 18, 2003; 198(4): 521 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Jensen and A. S. Whitehead Pellino3, a Novel Member of the Pellino Protein Family, Promotes Activation of c-Jun and Elk-1 and May Act as a Scaffolding Protein J. Immunol., August 1, 2003; 171(3): 1500 - 1506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Qureshi, P.-Y. Perera, J. Shen, G. Zhang, A. Lenschat, G. Splitter, D. C. Morrison, and S. N. Vogel The Proteasome as a Lipopolysaccharide-Binding Protein in Macrophages: Differential Effects of Proteasome Inhibition on Lipopolysaccharide-Induced Signaling Events J. Immunol., August 1, 2003; 171(3): 1515 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Hobbs and F. M. Watt Regulation of Interleukin-1{alpha} Expression by Integrins and Epidermal Growth Factor Receptor in Keratinocytes from a Mouse Model of Inflammatory Skin Disease J. Biol. Chem., May 23, 2003; 278(22): 19798 - 19807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Shen and J. L. Manley Pelle kinase is activated by autophosphorylation during Toll signaling in Drosophila Development, March 6, 2003; 129(8): 1925 - 1933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Burns, S. Janssens, B. Brissoni, N. Olivos, R. Beyaert, and J. Tschopp Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4 J. Exp. Med., January 20, 2003; 197(2): 263 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Yeo, J.-G. Yoon, S.-C. Hong, and A.-K. Yi CpG DNA Induces Self and Cross-Hyporesponsiveness of RAW264.7 Cells in Response to CpG DNA and Lipopolysaccharide: Alterations in IL-1 Receptor-Associated Kinase Expression J. Immunol., January 15, 2003; 170(2): 1052 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Jiang, J. Ninomiya-Tsuji, Y. Qian, K. Matsumoto, and X. Li Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol Mol. Cell. Biol., October 15, 2002; 22(20): 7158 - 7167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ross, L. Yang, S. Dower, F. Volpe, and F. Guesdon Identification of Threonine 66 as a Functionally Critical Residue of the Interleukin-1 Receptor-associated Kinase J. Biol. Chem., September 27, 2002; 277(40): 37414 - 37421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Adib-Conquy and J.-M. Cavaillon Gamma Interferon and Granulocyte/Monocyte Colony-stimulating Factor Prevent Endotoxin Tolerance in Human Monocytes by Promoting Interleukin-1 Receptor-associated Kinase Expression and Its Association to MyD88 and Not by Modulating TLR4 Expression J. Biol. Chem., July 26, 2002; 277(31): 27927 - 27934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Mamidipudi, X. Li, and M. W. Wooten Identification of Interleukin 1 Receptor-associated Kinase as a Conserved Component in the p75-Neurotrophin Receptor Activation of Nuclear Factor-kappa B J. Biol. Chem., July 26, 2002; 277(31): 28010 - 28018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sato, O. Takeuchi, T. Fujita, H. Tomizawa, K. Takeda, and S. Akira A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways Int. Immunol., July 1, 2002; 14(7): 783 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Chen, W.-T. Wu, F.-M. Ho, and W.-W. Lin Inhibition of Interleukin-1beta -induced NF-kappa B Activation by Calcium/Calmodulin-dependent Protein Kinase Kinase Occurs through Akt Activation Associated with Interleukin-1 Receptor-associated Kinase Phosphorylation and Uncoupling of MyD88 J. Biol. Chem., June 28, 2002; 277(27): 24169 - 24179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Radons, S. Gabler, H. Wesche, C. Korherr, R. Hofmeister, and W. Falk Identification of Essential Regions in the Cytoplasmic Tail of Interleukin-1 Receptor Accessory Protein Critical for Interleukin-1 Signaling J. Biol. Chem., May 3, 2002; 277(19): 16456 - 16463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Li, A. Strelow, E. J. Fontana, and H. Wesche IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase PNAS, April 16, 2002; 99(8): 5567 - 5572. [Abstract] [Full Text] [PDF]
|
|
|
