|
|
|
|||||||
|
|||||||||
(Received for publication, April 28, 1997, and in revised form, July 8, 1997)
From the A genetic model of salt-resistant hypertension
has been developed recently through disruption of the guanylyl
cyclase-A (GC-A) natriuretic peptide receptor gene (Lopez, M. J.,
Wong, S. K., Kishimoto, I., Dubois, S., Mach, V., Friesen, J.,
Garbers, D. L., and Beuve, A. (1995) Nature 378, 65-68). These genetically altered mice were used to determine which of
the natural peptides with natriuretic peptide-like structures regulate
blood pressure through the GC-A receptor. Atrial natriuretic peptide
(ANP) or B-type natriuretic peptide (BNP) half-maximally relaxed
precontracted aortic rings in wild-type mice at about 24 nM, but failed to relax such aortas in GC-A null mice, even
at micromolar concentrations. C-type natriuretic peptide (CNP), in
contrast, caused half-maximal relaxation at concentrations of 335 and
146 nM in aortas from either wild-type or null mice,
respectively, suggesting that this peptide acted through a receptor
other than GC-A. Since the in vitro results with aortic
smooth muscle do not necessarily reflect the physiology of the smaller
blood vessels important in blood pressure regulation, the blood
pressures of conscious mice infused with the various peptides were
determined. ANP caused decreases in blood pressure when infused at
rates of 500 ng/kg/min, a rate which resulted in a plasma concentration
of 0.8 nM. In the null mice, in contrast, ANP failed
to lower blood pressure even at infusion rates of 50 µg/kg/min. Much
higher infusion rates for CNP (50 µg/kg/min), which yielded final
plasma concentrations of 18.3 nM, were required to lower
blood pressure in wild-type mice, but the effects of CNP were not
altered in GC-A null mice. Thus, two natriuretic peptides (ANP, BNP)
act through GC-A whereas another (CNP) acts through another receptor to
regulate blood pressure.
Volume 272, Number 37,
Issue of September 12, 1997
pp. 23064-23068
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
§
,
and
Department of Pharmacology,
§ Department of Pediatrics, and 
Howard Hughes Medical
Institute, University of Texas Southwestern Medical Center, Dallas,
Texas 75235-9050
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  D. M. Dickey, A. R. Yoder, and L. R. Potter A Familial Mutation Renders Atrial Natriuretic Peptide Resistant to Proteolytic Degradation J. Biol. Chem., July 17, 2009; 284(29): 19196 - 19202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Gardner, S. Chen, D. J. Glenn, and C. L. Grigsby Molecular Biology of the Natriuretic Peptide System: Implications for Physiology and Hypertension Hypertension, March 1, 2007; 49(3): 419 - 426. [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Mullins, M. A. Bailey, and J. J. Mullins Hypertension, Kidney, and Transgenics: A Fresh Perspective Physiol Rev, April 1, 2006; 86(2): 709 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Potter, S. Abbey-Hosch, and D. M. Dickey Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions Endocr. Rev., February 1, 2006; 27(1): 47 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Patel, M. L. Valencik, A. M. Pritchett, J. C. Burnett Jr., J. A. McDonald, and M. M. Redfield Cardiac-specific attenuation of natriuretic peptide A receptor activity accentuates adverse cardiac remodeling and mortality in response to pressure overload Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H777 - H784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kuhn Structure, Regulation, and Function of Mammalian Membrane Guanylyl Cyclase Receptors, With a Focus on Guanylyl Cyclase-A Circ. Res., October 17, 2003; 93(8): 700 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ehmke Inducing vasoconstriction by activating guanylyl cyclase Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1376 - R1377. [Full Text] [PDF]
|
|
|
|
|
|
P. S. Andrew and S. Kaufman Guanylyl cyclase mediates ANP-induced vasoconstriction of murine splenic vessels Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1567 - R1571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sabrane, S. Gambaryan, R. P. Brandes, R. Holtwick, M. Voss, and M. Kuhn Increased Sensitivity to Endothelial Nitric Oxide (NO) Contributes to Arterial Normotension in Mice with Vascular Smooth Muscle-selective Deletion of the Atrial Natriuretic Peptide (ANP) Receptor J. Biol. Chem., May 9, 2003; 278(20): 17963 - 17968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Holtwick, M. Gotthardt, B. Skryabin, M. Steinmetz, R. Potthast, B. Zetsche, R. E. Hammer, J. Herz, and M. Kuhn Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure PNAS, May 14, 2002; 99(10): 7142 - 7147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Bryan and L. R. Potter The Atrial Natriuretic Peptide Receptor (NPR-A/GC-A) Is Dephosphorylated by Distinct Microcystin-sensitive and Magnesium-dependent Protein Phosphatases J. Biol. Chem., May 3, 2002; 277(18): 16041 - 16047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L King and M R Wilkins Natriuretic peptide receptors and the heart Heart, April 1, 2002; 87(4): 314 - 315. [Full Text] [PDF]
|
|
|
|
|
|
M Kuhn, R Holtwick, H A Baba, J C Perriard, W Schmitz, and E Ehler Progressive cardiac hypertrophy and dysfunction in atrial natriuretic peptide receptor (GC-A) deficient mice Heart, April 1, 2002; 87(4): 368 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pierkes, S. Gambaryan, P. Boknik, S. M. Lohmann, W. Schmitz, R. Potthast, R. Holtwick, and M. Kuhn Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice Cardiovasc Res, March 1, 2002; 53(4): 852 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Sagnella Atrial natriuretic peptide mimetics and vasopeptidase inhibitors Cardiovasc Res, August 15, 2001; 51(3): 416 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pedram, M. Razandi, and E. R. Levin Natriuretic Peptides Suppress Vascular Endothelial Cell Growth Factor Signaling to Angiogenesis Endocrinology, April 1, 2001; 142(4): 1578 - 1586. [Abstract] [Full Text]
|
|
|
|
|
|
I. Kishimoto, K. Rossi, and D. L. Garbers A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy PNAS, February 8, 2001; (2001) 51625598. [Abstract] [Full Text]
|
|
|
|
|
|
H. Chusho, Y. Ogawa, N. Tamura, M. Suda, A. Yasoda, T. Miyazawa, I. Kishimoto, Y. Komatsu, H. Itoh, K. Tanaka, et al. Genetic Models Reveal That Brain Natriuretic Peptide Can Signal through Different Tissue-Specific Receptor-Mediated Pathways Endocrinology, October 1, 2000; 141(10): 3807 - 3813. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Lucas, G. M. Pitari, S. Kazerounian, I. Ruiz-Stewart, J. Park, S. Schulz, K. P. Chepenik, and S. A. Waldman Guanylyl Cyclases and Signaling by Cyclic GMP Pharmacol. Rev., September 1, 2000; 52(3): 375 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Faraci and C. D. Sigmund Vascular Biology in Genetically Altered Mice : Smaller Vessels, Bigger Insight Circ. Res., December 3, 1999; 85(12): 1214 - 1225. [Full Text] [PDF]
|
|
|
|
|
|
K. N. Pandey, P. M. Oliver, N. Maeda, and O. Smithies Hypertension Associated with Decreased Testosterone Levels in Natriuretic Peptide Receptor-A Gene-Knockout and Gene-Duplicated Mutant Mouse Models Endocrinology, November 1, 1999; 140(11): 5112 - 5119. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. Zhao, L. Long, N. W. Morrell, and M. R. Wilkins NPR-A–Deficient Mice Show Increased Susceptibility to Hypoxia-Induced Pulmonary Hypertension Circulation, February 9, 1999; 99(5): 605 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Olson, B. Y. Ho, L. W. Cashdollar, and J. G. Drewett Functionally Active Catalytic Domain Is Essential for Guanylyl Cyclase-Linked Receptor Mediated Inhibition of Human Aldosterone Synthesis Mol. Pharmacol., November 1, 1998; 54(5): 761 - 769. [Abstract] [Full Text]
|
|
|
|
|
|
I. Kishimoto, K. Rossi, and D. L. Garbers A genetic model provides evidence that the receptor for atrial natriuretic peptide (guanylyl cyclase-A) inhibits cardiac ventricular myocyte hypertrophy PNAS, February 27, 2001; 98(5): 2703 - 2706. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |