JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sciorati, C.
Right arrow Articles by Clementi, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sciorati, C.
Right arrow Articles by Clementi, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Volume 272, Number 37, Issue of September 12, 1997 pp. 23211-23215
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

Autocrine Nitric Oxide Modulates CD95-induced Apoptosis in gamma delta T Lymphocytes

(Received for publication, June 20, 1997)

Clara Sciorati Dagger , Patrizia Rovere § , Marina Ferrarini § , Silvia Heltai § , Angelo A. Manfredi § and Emilio Clementi Dagger

From the Dagger  Receptor Biochemistry Unit, DIBIT and § Second Department of Medicine, Laboratory of Cancer Immunology, Scientific Institute Ospedale San Raffaele and the  Department of Pharmacology, School of Pharmacy, CNR-IBAF, University of Reggio Calabria, 88021 Catanzaro and Consiglio Nazionale delle Ricerche Cellular and Molecular Pharmacology Centre, Via Olgettina 58, 20132 Milano, Italy

gamma delta T lymphocytes play an important early role in the defense against pathogens. Their function is terminated by acquisition of susceptibility to CD95-triggered apoptosis. Here we show that the regulation of this process depends on the activity of the endothelial NO synthase expressed by gamma delta T lymphocytes, which is modulated in an activation-dependent way. The effects of nitric oxide thus generated, mediated via cGMP generation, are exerted at at least two sites along the CD95 signaling cascade: one at, or upstream, and the other downstream of ceramide generation. At either site, nitric oxide/cGMP action is sufficient for protection from apoptosis. The effect of NO is selective for apoptosis induced by CD95 cross-linking, since it does not affect apoptotic program triggered by other stimuli. The evidence here reported demonstrates a new physiological role for nitric oxide, acting as a survival factor for T lymphocytes.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Cell Biol.Home page
D. Deponti, S. Francois, S. Baesso, C. Sciorati, A. Innocenzi, V. Broccoli, F. Muscatelli, R. Meneveri, E. Clementi, G. Cossu, et al.
Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation
J. Cell Biol., October 22, 2007; 179(2): 305 - 319.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. Sciorati, B. G. Galvez, S. Brunelli, E. Tagliafico, S. Ferrari, G. Cossu, and E. Clementi
Ex vivo treatment with nitric oxide increases mesoangioblast therapeutic efficacy in muscular dystrophy
J. Cell Sci., December 15, 2006; 119(24): 5114 - 5123.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
C. Panzeri, C. De Palma, A. Martinuzzi, A. Daga, G. De Polo, N. Bresolin, C. C. Miller, E. L. Tudor, E. Clementi, and M. T. Bassi
The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function
Brain, July 1, 2006; 129(7): 1710 - 1719.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Falcone, C. Perrotta, C. De Palma, A. Pisconti, C. Sciorati, A. Capobianco, P. Rovere-Querini, A. A. Manfredi, and E. Clementi
Activation of Acid Sphingomyelinase and Its Inhibition by the Nitric Oxide/Cyclic Guanosine 3',5'-Monophosphate Pathway: Key Events in Escherichia coli-Elicited Apoptosis of Dendritic Cells
J. Immunol., October 1, 2004; 173(7): 4452 - 4463.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Perrotta, S. Falcone, A. Capobianco, A. Camporeale, C. Sciorati, C. D. Palma, A. Pisconti, P. Rovere-Querini, M. Bellone, A. A. Manfredi, et al.
Nitric Oxide Confers Therapeutic Activity to Dendritic Cells in a Mouse Model of Melanoma
Cancer Res., June 1, 2004; 64(11): 3767 - 3771.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Nagy, A. Koncz, and A. Perl
T Cell Activation-Induced Mitochondrial Hyperpolarization Is Mediated by Ca2+- and Redox-Dependent Production of Nitric Oxide
J. Immunol., November 15, 2003; 171(10): 5188 - 5197.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
R. Barsacchi, C. Perrotta, S. Bulotta, S. Moncada, N. Borgese, and E. Clementi
Activation of Endothelial Nitric-Oxide Synthase by Tumor Necrosis Factor-alpha : A Novel Pathway Involving Sequential Activation of Neutral Sphingomyelinase, Phosphatidylinositol-3' kinase, and Akt
Mol. Pharmacol., April 1, 2003; 63(4): 886 - 895.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T.-A. Kim, H. K. Avraham, Y.-H. Koh, S. Jiang, I.-W. Park, and S. Avraham
HIV-1 Tat-Mediated Apoptosis in Human Brain Microvascular Endothelial Cells
J. Immunol., March 1, 2003; 170(5): 2629 - 2637.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Takuma, P. Phuagphong, E. Lee, K. Mori, A. Baba, and T. Matsuda
Anti-apoptotic Effect of cGMP in Cultured Astrocytes. INHIBITION BY cGMP-DEPENDENT PROTEIN KINASE OF MITOCHONDRIAL PERMEABLE TRANSITION PORE
J. Biol. Chem., December 14, 2001; 276(51): 48093 - 48099.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. L. Jiménez, J. González-Nicolás, S. Alvarez, M. Fresno, and M. A. Muñoz-Fernández
Regulation of Human Immunodeficiency Virus Type 1 Replication in Human T Lymphocytes by Nitric Oxide
J. Virol., May 15, 2001; 75(10): 4655 - 4663.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
R. P. Cherla and R. K. Ganju
Stromal Cell-Derived Factor 1{{alpha}}-Induced Chemotaxis in T Cells Is Mediated by Nitric Oxide Signaling Pathways
J. Immunol., March 1, 2001; 166(5): 3067 - 3074.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
T. Polte, A. Abate, P. A. Dennery, and H. Schroder
Heme Oxygenase-1 Is a cGMP-Inducible Endothelial Protein and Mediates the Cytoprotective Action of Nitric Oxide
Arterioscler. Thromb. Vasc. Biol., May 1, 2000; 20(5): 1209 - 1215.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. F. Romano, A. Lamberti, R. Bisogni, C. Garbi, A. M. Pagnano, P. Auletta, P. Tassone, M. C. Turco, and S. Venuta
Amifostine Inhibits Hematopoietic Progenitor Cell Apoptosis by Activating NF-kappa B/Rel Transcription Factors
Blood, December 15, 1999; 94(12): 4060 - 4066.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y.-M. Kim, H.-T. Chung, S.-S. Kim, J.-A Han, Y.-M. Yoo, K.-M. Kim, G.-H. Lee, H.-Y. Yun, A. Green, J. Li, et al.
Nitric Oxide Protects PC12 Cells from Serum Deprivation-Induced Apoptosis by cGMP-Dependent Inhibition of Caspase Signaling
J. Neurosci., August 15, 1999; 19(16): 6740 - 6747.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Sciorati, P. Rovere, M. Ferrarini, C. Paolucci, S. Heltai, R. Vaiani, E. Clementi, and A. A. Manfredi
Generation of Nitric Oxide by the Inducible Nitric Oxide Synthase Protects {gamma}{delta} T Cells from Mycobacterium tuberculosis-Induced Apoptosis
J. Immunol., August 1, 1999; 163(3): 1570 - 1576.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Li, C. A. Bombeck, S. Yang, Y.-M. Kim, and T. R. Billiar
Nitric Oxide Suppresses Apoptosis via Interrupting Caspase Activation and Mitochondrial Dysfunction in Cultured Hepatocytes
J. Biol. Chem., June 11, 1999; 274(24): 17325 - 17333.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-P. Lievremont, C. Sciorati, E. Morandi, C. Paolucci, G. Bunone, G. Della Valle, J. Meldolesi, and E. Clementi
The p75NTR-induced Apoptotic Program Develops through a Ceramide-Caspase Pathway Negatively Regulated by Nitric Oxide
J. Biol. Chem., May 28, 1999; 274(22): 15466 - 15472.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. S. Williams, S. Noguchi, P. A. Henkart, and Y. Osawa
Nitric Oxide Synthase Plays a Signaling Role in TCR-Triggered Apoptotic Death
J. Immunol., December 15, 1998; 161(12): 6526 - 6531.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Y. M. W. Janssen, R. Soultanakis, K. Steece, E. Heerdt, R. J. Singh, J. Joseph, and B. Kalyanaraman
Depletion of nitric oxide causes cell cycle alterations, apoptosis, and oxidative stress in pulmonary cells
Am J Physiol Lung Cell Mol Physiol, December 1, 1998; 275(6): L1100 - L1109.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. Kim, O. Bang, Y. Lee, and S. Kang
Production of inducible nitric oxide is required for monocytic differentiation of U937 cells induced by vitamin E-succinate
J. Cell Sci., January 2, 1998; 111(4): 435 - 441.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
C. Paolucci, P. Rovere, C. De Nadai, A. A. Manfredi, and E. Clementi
Nitric Oxide Inhibits the Tumor Necrosis Factor alpha -regulated Endocytosis of Human Dendritic Cells in a Cyclic GMP-dependent Way
J. Biol. Chem., June 23, 2000; 275(26): 19638 - 19644.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Bulotta, R. Barsacchi, D. Rotiroti, N. Borgese, and E. Clementi
Activation of the Endothelial Nitric-oxide Synthase by Tumor Necrosis Factor-alpha . A NOVEL FEEDBACK MECHANISM REGULATING CELL DEATH
J. Biol. Chem., February 23, 2001; 276(9): 6529 - 6536.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. De Nadai, P. Sestili, O. Cantoni, J.-P. Lievremont, C. Sciorati, R. Barsacchi, S. Moncada, J. Meldolesi, and E. Clementi
Nitric oxide inhibits tumor necrosis factor-alpha -induced apoptosis by reducing the generation of ceramide
PNAS, May 9, 2000; 97(10): 5480 - 5485.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1997 by the American Society for Biochemistry and Molecular Biology.