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Volume 272, Number 38, Issue of September 19, 1997 pp. 23473-23476
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

COMMUNICATION:
Proteinase-mediated Insect Resistance to Bacillus thuringiensis Toxins

(Received for publication, June 4, 1997, and in revised form, July 7, 1997)

From the United States Grain Marketing Research Laboratory, United States Department of Agriculture, Agricultural Research Service, Manhattan, Kansas 66502-2736

Two Bacillus thuringiensis (Bt)-resistant strains of the Indianmeal moth, Plodia interpunctella, lack a major gut proteinase that activates Bt protoxins. The absence of this enzyme is genetically linked to larval survival on Bt-treated diets. When considered with previous data supporting the existence of receptor-mediated insect resistance to Bt, these results provide evidence that insect adaptation to these toxins occurs through multiple physiological mechanisms, which complicate efforts to prevent or manage resistance to Bt toxins in insect control programs.

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