JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oka, T.
Right arrow Articles by Futai, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oka, T.
Right arrow Articles by Futai, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Volume 272, Number 39, Issue of September 26, 1997 pp. 24387-24392
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

Three vha Genes Encode Proteolipids of Caenorhabditis elegans Vacuolar-type ATPase
GENE STRUCTURES AND PREFERENTIAL EXPRESSION IN AN H-SHAPED EXCRETORY CELL AND RECTAL CELLS

(Received for publication, May 13, 1997, and in revised form, July 7, 1997)

Toshihiko Oka , Ryuji Yamamoto and Masamitsu Futai

From the Department of Molecular Cell Biology, Division of Biological Science, Institute of Scientific and Industrial Research, Osaka University, Osaka 567, Japan

The proteolipids of the vacuolar-type H+-ATPase (V-ATPase) are major components of the integral membrane sector. The vha-1 and vha-2 (vacuolar-type H+-ATPase) genes in Caenorhabditis elegans encode putative 16-kDa proteolipids and are tandemly localized on chromosome III. The vha-2 gene has three exons, whereas vha-1 has no introns. The deduced amino acid sequences of the two genes exhibit about 60% identity with the homologues from yeast, mouse, and cow. The mRNAs of both vha genes are trans-spliced to spliced leaders, suggesting that these genes constitute a polycistronic transcriptional unit. The vha-4 gene consists of four exons and is very similar to the yeast VMA16 gene that codes for the 23-kDa proteolipid. This is the first example of three distinct V-ATPase proteolipids being identified in higher eukaryotes. Northern blot and transgenic analyses show that the three vha genes may be highly expressed in the H-shaped excretory cell, rectum, and a pair of cells posterior to the anus. These results suggest that the V-ATPase activity may be important for exporting toxic compounds or metabolic wastes in this organism.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 PhysiologyHome page
O. Drory and N. Nelson
The emerging structure of vacuolar ATPases.
Physiology, October 1, 2006; 21: 317 - 325.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Watanabe, Y. Nagamatsu, K. Gengyo-Ando, S. Mitani, and Y. Ohshima
Control of body size by SMA-5, a homolog of MAP kinase BMK1/ERK5, in C. elegans
Development, July 15, 2005; 132(14): 3175 - 3184.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
K. Aviezer-Hagai, V. Padler-Karavani, and N. Nelson
Biochemical support for the V-ATPase rotary mechanism: antibody against HA-tagged Vma7p or Vma16p but not Vma10p inhibits activity
J. Exp. Biol., September 15, 2003; 206(18): 3227 - 3237.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. A. T. DOW and S. A. DAVIES
Integrative Physiology and Functional Genomics of Epithelial Function in a Genetic Model Organism
Physiol Rev, July 1, 2003; 83(3): 687 - 729.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Toyomura, Y. Murata, A. Yamamoto, T. Oka, G.-H. Sun-Wada, Y. Wada, and M. Futai
From Lysosomes to the Plasma Membrane: LOCALIZATION OF VACUOLAR TYPE H+-ATPase WITH THE a3 ISOFORM DURING OSTEOCLAST DIFFERENTIATION
J. Biol. Chem., June 6, 2003; 278(24): 22023 - 22030.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
O. Uchida, H. Nakano, M. Koga, and Y. Ohshima
The C. elegans che-1 gene encodes a zinc finger transcription factor required for specification of the ASE chemosensory neurons
Development, April 1, 2003; 130(7): 1215 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. Burglin and G Ruvkun
Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6
Development, January 3, 2001; 128(5): 779 - 790.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
T. Toyomura, T. Oka, C. Yamaguchi, Y. Wada, and M. Futai
Three Subunit a Isoforms of Mouse Vacuolar H+-ATPase. PREFERENTIAL EXPRESSION OF THE a3 ISOFORM DURING OSTEOCLAST DIFFERENTIATION
J. Biol. Chem., March 17, 2000; 275(12): 8760 - 8765.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
M Futai, T Oka, G Sun-Wada, Y Moriyama, H Kanazawa, and Y Wada
Luminal acidification of diverse organelles by V-ATPase in animal cells
J. Exp. Biol., January 1, 2000; 203(1): 107 - 116.
[Abstract]

Home page
 J. Biol. Chem.Home page
S. Rahlfs, S. Aufurth, and V. Muller
The Na+-F1F0-ATPase Operon from Acetobacterium woodii. OPERON STRUCTURE AND PRESENCE OF MULTIPLE COPIES OF atpE WHICH ENCODE PROTEOLIPIDS OF 8- AND 18-kDa
J. Biol. Chem., November 26, 1999; 274(48): 33999 - 34004.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Nelson and W. R. Harvey
Vacuolar and Plasma Membrane Proton-Adenosinetriphosphatases
Physiol Rev, April 1, 1999; 79(2): 361 - 385.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Oka, R. Yamamoto, and M. Futai
Multiple Genes for Vacuolar-type ATPase Proteolipids in Caenorhabditis elegans. A NEW GENE, vha-3, HAS A DISTINCT CELL-SPECIFIC DISTRIBUTION
J. Biol. Chem., August 28, 1998; 273(35): 22570 - 22576.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Oka and M. Futai
Requirement of V-ATPase for Ovulation and Embryogenesis in Caenorhabditis elegans
J. Biol. Chem., September 15, 2000; 275(38): 29556 - 29561.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Powell, L. A. Graham, and T. H. Stevens
Molecular Characterization of the Yeast Vacuolar H+-ATPase Proton Pore
J. Biol. Chem., July 28, 2000; 275(31): 23654 - 23660.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Pujol, C. Bonnerot, J. J. Ewbank, Y. Kohara, and D. Thierry-Mieg
The Caenorhabditis elegans unc-32 Gene Encodes Alternative Forms of a Vacuolar ATPase a Subunit
J. Biol. Chem., April 6, 2001; 276(15): 11913 - 11921.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Oka, T. Toyomura, K. Honjo, Y. Wada, and M. Futai
Four Subunit a Isoforms of Caenorhabditis elegans Vacuolar H+-ATPase. CELL-SPECIFIC EXPRESSION DURING DEVELOPMENT
J. Biol. Chem., August 24, 2001; 276(35): 33079 - 33085.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Nishi, S. Kawasaki-Nishi, and M. Forgac
Expression and Localization of the Mouse Homologue of the Yeast V-ATPase 21-kDa Subunit c'' (Vma16p)
J. Biol. Chem., August 31, 2001; 276(36): 34122 - 34130.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. K. Curtis, S. A. Francis, Y. Oluwatosin, and P. M. Kane
Mutational Analysis of the Subunit C (Vma5p) of the Yeast Vacuolar H+-ATPase
J. Biol. Chem., March 8, 2002; 277(11): 8979 - 8988.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1997 by the American Society for Biochemistry and Molecular Biology.