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-Catenin
(Received for publication, June 23, 1997)
,
,
From the Several lines of evidence suggest that
accumulation of cytoplasmic 
Lombardi Cancer Center, Georgetown
University Medical Center, Washington, D. C. 20007 and the
§ NCI, DCBD, National Institutes of Health,
Bethesda, Maryland 20892
-catenin transduces an oncogenic signal.
We show that -catenin is ubiquitinated and degraded by the
proteosome and that -catenin stability is regulated by a
diacylglycerol-independent protein kinase C-like kinase activity, which
is required for -catenin ubiquitination. We also define a six-amino
acid sequence found in both -catenin and the NF-
B regulatory
protein IB
, which, upon phosphorylation, targets both proteins
for ubiquitination. Mutation of a single serine within the
ubiquitination targeting sequence prevents ubiquitination of
-catenin. Mutations within the ubiquitination targeting sequence of
-catenin may be oncogenic.
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