| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, June 19, 1997, and in revised form, August 12, 1997)
From the Divisions of Tec is the prototype of a recently emerging
subfamily among nonreceptor type protein-tyrosine kinases and is known
to become tyrosine-phosphorylated and activated by a wide range of
cytokine stimulations in hematopoietic cells. Although Tec was recently shown to be involved in the cytokine-driven activation mechanism of
c-fos transcription, it is yet obscure how Tec relays the
signals from cell surface receptors to the nucleus. To identify
signaling molecules acting downstream of Tec, we have looked for
Tec-interacting proteins (TIPs) by using the yeast two-hybrid system.
Here we report the identification and characterization of a novel
protein, TIP3, which has been simultaneously identified by other groups as SOCS-1, JAB, or SSI-1. TIP3 carries one Src homology 2 domain with a
sequence similarity to that of CIS. In 293 cells, TIP3 associates with
Tec and suppresses its kinase activity. Interestingly, TIP3 can also
down-regulate the activity of Jak2 but not that of Lyn. We propose that
SOCS-1/JAB/SSI-1/TIP3 is a novel type of negative regulator to a subset
of protein-tyrosine kinases.
Volume 272, Number 43,
Issue of October 24, 1997
pp. 27178-27182
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
SOCS-1/JAB/SSI-1 Can Bind to and Suppress Tec Protein-tyrosine
Kinase
,
,
,
,
,
,
Cardiology and
Hematology and the ¶ Department of Molecular Biology, Jichi
Medical School, 3311-1 Yakushiji, Kawachi-gun, Tochigi 329-04, Japan
and the § Hematology Branch, NHLBI, National Institutes of
Health, Bethesda, Maryland 20892
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Brender, G. M. Tannahill, B. J. Jenkins, J. Fletcher, R. Columbus, C. J. M. Saris, M. Ernst, N. A. Nicola, D. J. Hilton, W. S. Alexander, et al. Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27 Blood, October 1, 2007; 110(7): 2528 - 2536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Qasimi, A. Ming-Lum, A. Ghanipour, C. J. Ong, M. E. Cox, J. Ihle, N. Cacalano, A. Yoshimura, and A. L-F. Mui Divergent Mechanisms Utilized by SOCS3 to Mediate Interleukin-10 Inhibition of Tumor Necrosis Factor {alpha} and Nitric Oxide Production by Macrophages J. Biol. Chem., March 10, 2006; 281(10): 6316 - 6324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Inagaki-Ohara, A Sasaki, G Matsuzaki, T Ikeda, M Hotokezaka, K Chijiiwa, M Kubo, H Yoshida, Y Nawa, and A Yoshimura Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice Gut, February 1, 2006; 55(2): 212 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lennartsson, T. Jelacic, D. Linnekin, and R. Shivakrupa Normal and Oncogenic Forms of the Receptor Tyrosine Kinase Kit Stem Cells, January 1, 2005; 23(1): 16 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-J. M. van de Geijn, J. Gits, L. H. J. Aarts, C. Heijmans-Antonissen, and I. P. Touw G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact Blood, August 1, 2004; 104(3): 667 - 674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kimura, T. Naka, S. Nagata, I. Kawase, and T. Kishimoto SOCS-1 suppresses TNF-{alpha}-induced apoptosis through the regulation of Jak activation Int. Immunol., July 1, 2004; 16(7): 991 - 999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Gomez-Guerrero, O. Lopez-Franco, G. Sanjuan, P. Hernandez-Vargas, Y. Suzuki, G. Ortiz-Munoz, J. Blanco, and J. Egido Suppressors of Cytokine Signaling Regulate Fc Receptor Signaling and Cell Activation during Immune Renal Injury J. Immunol., June 1, 2004; 172(11): 6969 - 6977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Cornish, M. M. Chong, G. M. Davey, R. Darwiche, N. A. Nicola, D. J. Hilton, T. W. Kay, R. Starr, and W. S. Alexander Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other {gamma}c-dependent Cytokines in Peripheral T Cells J. Biol. Chem., June 13, 2003; 278(25): 22755 - 22761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Wesemann, Y. Dong, G. M. O'Keefe, V. T. Nguyen, and E. N. Benveniste Suppressor of Cytokine Signaling 1 Inhibits Cytokine Induction of CD40 Expression in Macrophages J. Immunol., September 1, 2002; 169(5): 2354 - 2360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. W. Chong, H. E. Thomas, and T. W. H. Kay Suppressor of Cytokine Signaling-1 Regulates the Sensitivity of Pancreatic beta Cells to Tumor Necrosis Factor J. Biol. Chem., July 26, 2002; 277(31): 27945 - 27952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Tam, P. Lau, J. Djiane, D. J. Hilton, and M. J. Waters Tissue-Specific Induction of SOCS Gene Expression by PRL Endocrinology, November 1, 2001; 142(11): 5015 - 5026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamashita, S. Kajigaya, K. Yoshida, S. Ueno, J. Ota, K. Ohmine, M. Ueda, A. Miyazato, K.-i. Ohya, T. Kitamura, et al. Sak Serine-Threonine Kinase Acts as an Effector of Tec Tyrosine Kinase J. Biol. Chem., October 12, 2001; 276(42): 39012 - 39020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C V Clevenger and J B Kline Prolactin receptor signal transduction Lupus, October 1, 2001; 10(10): 706 - 718. [Abstract] [PDF]
|
|
|
|
|
|
A. H. Dalpke, S. Opper, S. Zimmermann, and K. Heeg Suppressors of Cytokine Signaling (SOCS)-1 and SOCS-3 Are Induced by CpG-DNA and Modulate Cytokine Responses in APCs J. Immunol., June 15, 2001; 166(12): 7082 - 7089. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Kline, D. J. Moore, and C. V. Clevenger Activation and Association of the Tec Tyrosine Kinase with the Human Prolactin Receptor: Mapping of a Tec/Vav1-Receptor Binding Site Mol. Endocrinol., May 1, 2001; 15(5): 832 - 841. [Abstract] [Full Text]
|
|
|
|
|
|
B. Sporri, P. E. Kovanen, A. Sasaki, A. Yoshimura, and W. J. Leonard JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling Blood, January 1, 2001; 97(1): 221 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. L. Bergad, S. J. Schwarzenberg, J. T. Humbert, M. Morrison, S. Amarasinghe, H. C. Towle, and S. A. Berry Inhibition of growth hormone action in models of inflammation Am J Physiol Cell Physiol, December 1, 2000; 279(6): C1906 - C1917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fujimoto, T. Naka, R. Nakagawa, Y. Kawazoe, Y. Morita, A. Tateishi, K. Okumura, M. Narazaki, and T. Kishimoto Defective Thymocyte Development and Perturbed Homeostasis of T cells in STAT-Induced STAT Inhibitor-1/Suppressors of Cytokine Signaling-1 Transgenic Mice J. Immunol., August 15, 2000; 165(4): 1799 - 1806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Emanuelli, P. Peraldi, C. Filloux, D. Sawka-Verhelle, D. Hilton, and E. Van Obberghen SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling J. Biol. Chem., May 19, 2000; 275(21): 15985 - 15991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Li, S. Chen, X. Xu, A. Sundstedt, K. M. Paulsson, P. Anderson, S. Karlsson, H.-O. Sjogren, and P. Wang Cytokine-induced Src Homology 2 Protein (CIS) Promotes T Cell Receptor-mediated Proliferation and Prolongs Survival of Activated T Cells J. Exp. Med., March 20, 2000; 191(6): 985 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. K. Teague, B. C. Schaefer, D. Hildeman, J. Bender, T. Mitchell, J. W. Kappler, and P. Marrack Activation-induced Inhibition of Interleukin 6-mediated T Cell Survival and Signal Transducer and Activator of Transcription 1 Signaling J. Exp. Med., March 13, 2000; 191(6): 915 - 926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Krebs and D. Hilton SOCS: physiological suppressors of cytokine signaling J. Cell Sci., January 8, 2000; 113(16): 2813 - 2819. [Abstract] [PDF]
|
|
|
|
|
|
A. C. Ward, I. Touw, and A. Yoshimura The Jak-Stat pathway in normal and perturbed hematopoiesis Blood, January 1, 2000; 95(1): 19 - 29. [Full Text] [PDF]
|
|
|
|
|
|
D. E. Isaksen, H. Baumann, P. A. Trobridge, A. G. Farr, S. D. Levin, and S. F. Ziegler Requirement for Stat5 in Thymic Stromal Lymphopoietin-Mediated Signal Transduction J. Immunol., December 1, 1999; 163(11): 5971 - 5977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bjorbak, K. El-Haschimi, J. D. Frantz, and J. S. Flier The Role of SOCS-3 in Leptin Signaling and Leptin Resistance J. Biol. Chem., October 15, 1999; 274(42): 30059 - 30065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-i. Ohya, S. Kajigaya, A. Kitanaka, K. Yoshida, A. Miyazato, Y. Yamashita, T. Yamanaka, U. Ikeda, K. Shimada, K. Ozawa, et al. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase PNAS, October 12, 1999; 96(21): 11976 - 11981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Dickensheets, C. Venkataraman, U. Schindler, and R. P. Donnelly Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression PNAS, September 14, 1999; 96(19): 10800 - 10805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pezet, H. Favre, P. A. Kelly, and M. Edery Inhibition and Restoration of Prolactin Signal Transduction by Suppressors of Cytokine Signaling J. Biol. Chem., August 27, 1999; 274(35): 24497 - 24502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Tollet-Egnell, A. Flores-Morales, A. Stavréus-Evers, L. Sahlin, and G. Norstedt Growth Hormone Regulation of SOCS-2, SOCS-3, and CIS Messenger Ribonucleic Acid Expression in the Rat Endocrinology, August 1, 1999; 140(8): 3693 - 3704. [Abstract] [Full Text]
|
|
|
|
|
|
C. Venkataraman, S. Leung, A. Salvekar, H. Mano, and U. Schindler Repression of IL-4-Induced Gene Expression by IFN-{gamma} Requires Stat1 Activation J. Immunol., April 1, 1999; 162(7): 4053 - 4061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.G. Begley and N.A. Nicola Resolving Conflicting Signals: Cross Inhibition of Cytokine Signaling Pathways Blood, March 1, 1999; 93(5): 1443 - 1447. [Full Text] [PDF]
|
|
|
|
|
|
W.-C. Yang, M. Ghiotto, B. Barbarat, and D. Olive The Role of Tec Protein-tyrosine Kinase in T Cell Signaling J. Biol. Chem., January 8, 1999; 274(2): 607 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Song and K. Shuai The Suppressor of Cytokine Signaling (SOCS) 1 and SOCS3 but Not SOCS2 Proteins Inhibit Interferon-mediated Antiviral and Antiproliferative Activities J. Biol. Chem., December 25, 1998; 273(52): 35056 - 35062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kamura, S. Sato, D. Haque, L. Liu, W. G. Kaelin Jr., R. C. Conaway, and J. W. Conaway The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families Genes & Dev., December 15, 1998; 12(24): 3872 - 3881. [Abstract] [Full Text]
|
|
|
|
|
|
B. R. Dey, S. L. Spence, P. Nissley, and R. W. Furlanetto Interaction of Human Suppressor of Cytokine Signaling (SOCS)-2 with the Insulin-like Growth Factor-I Receptor J. Biol. Chem., September 11, 1998; 273(37): 24095 - 24101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Auernhammer, V. Chesnokova, C. Bousquet, and S. Melmed Pituitary Corticotroph SOCS-3: Novel Intracellular Regulation of Leukemia-Inhibitory Factor-Mediated Proopiomelanocortin Gene Expression and Adrenocorticotropin Secretion Mol. Endocrinol., July 1, 1998; 12(7): 954 - 961. [Abstract] [Full Text]
|
|
|
|
|
|
R. P. Bourette, P. De Sepulveda, S. Arnaud, P. Dubreuil, R. Rottapel, and G. Mouchiroud Suppressor of Cytokine Signaling 1 Interacts with the Macrophage Colony-stimulating Factor Receptor and Negatively Regulates Its Proliferation Signal J. Biol. Chem., June 15, 2001; 276(25): 22133 - 22139. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
