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Volume 272, Number 44, Issue of October 31, 1997 pp. 27818-27822
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

rRNA Maturation as a "Quality" Control Step in Ribosomal Subunit Assembly in Dictyostelium discoideum

(Received for publication, May 21, 1997, and in revised form, August 19, 1997)

From the Department of Clinical and Biological Sciences, Ospedale S. Luigi, Orbassano, Torino, Italy

In Dictyostelium discoideum, newly assembled ribosomal subunits enter polyribosomes while they still contain immature rRNA. rRNA maturation requires the engagement of the subunits in protein synthesis and leads to stabilization of their structure. Maturation of pre-17 S rRNA occurs only after the newly formed 40 S ribosomal particle has entered an 80 S ribosome and participated at least in the formation of one peptide bond or in one translocation event; maturation of pre-26 S rRNA requires the presence on the 80 S particle of a peptidyl-tRNA containing at least 6 amino acids. Newly assembled particles that cannot fulfill these requirements for structural reasons are disassembled into free immature rRNA and ribosomal proteins.

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