|
|
|
|||||||
|
|||||||||
(Received for publication, June 30, 1997)
From the Department of Molecular Pharmacology, Stanford University
School of Medicine, Stanford, California 94305-5332
We analyzed mouse hepatoma cells using
differential display to discover new genes that respond to the
environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). We identified a
class I major histocompatibility complex (MHC) gene, which we
designated as MHC Q1b, whose expression decreases
in the presence of TCDD. TCDD-induced down-regulation of MHC
Q1b requires both the aromatic hydrocarbon receptor
and the aromatic hydrocarbon receptor nuclear translocator,
transcription factors that up-regulate other genes in response to TCDD.
Down-regulation of MHC Q1b by TCDD appears to
involve both transcriptional and post-transcriptional regulatory
events; the post-transcriptional destabilization of MHC
Q1b mRNA is probably a secondary response to
TCDD. Our findings reveal new mechanistic aspects of gene regulation by
TCDD. In addition, our observations suggest a mechanism that might
account for some of TCDD's immunotoxic effects.
Volume 272, Number 47,
Issue of November 21, 1997
pp. 29614-29619
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
Down-regulation of Major Histocompatibility Complex
Q1b Gene Expression by
2,3,7,8-Tetrachlorodibenzo-p-dioxin
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Joiakim, P. A. Mathieu, A. A. Elliott, and J. J. Reiners Jr. Superinduction of CYP1A1 in MCF10A Cultures by Cycloheximide, Anisomycin, and Puromycin: A Process Independent of Effects on Protein Translation and Unrelated to Suppression of Aryl Hydrocarbon Receptor Proteolysis by the Proteasome Mol. Pharmacol., October 1, 2004; 66(4): 936 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Caruso, P. A. Mathieu, A. Joiakim, B. Leeson, D. Kessel, B. F. Sloane, and J. J. Reiners Jr. Differential Susceptibilities of Murine Hepatoma 1c1c7 and Tao Cells to the Lysosomal Photosensitizer NPe6: Influence of Aryl Hydrocarbon Receptor on Lysosomal Fragility and Protease Contents Mol. Pharmacol., April 1, 2004; 65(4): 1016 - 1028. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Joiakim, P. A. Mathieu, C. Palermo, T. A. Gasiewicz, and J. J. Reiners Jr. THE JUN N-TERMINAL KINASE INHIBITOR SP600125 IS A LIGAND AND ANTAGONIST OF THE ARYL HYDROCARBON RECEPTOR Drug Metab. Dispos., November 1, 2003; 31(11): 1279 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Soprano and K. J. Soprano Pharmacological Doses of Some Synthetic Retinoids Can Modulate Both the Aryl Hydrocarbon Receptor and Retinoid Receptor Pathways J. Nutr., January 1, 2003; 133(1): 277S - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Kumar, P. Ramadoss, R. K. Reen, J. P. Vanden Heuvel, and G. H. Perdew The Q-rich Subdomain of the Human Ah Receptor Transactivation Domain Is Required for Dioxin-mediated Transcriptional Activity J. Biol. Chem., November 2, 2001; 276(45): 42302 - 42310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Svensson and K. Lundberg Immune-Specific Up-Regulation of Adseverin Gene Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Mol. Pharmacol., July 1, 2001; 60(1): 135 - 142. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. R. Krig and R. H. Rice TCDD Suppression of Tissue Transglutaminase Stimulation by Retinoids in Malignant Human Keratinocytes Toxicol. Sci., August 1, 2000; 56(2): 357 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gao, L. Dong, and J. P. Whitlock Jr. A Novel Response to Dioxin. INDUCTION OF ECTO-ATPase GENE EXPRESSION J. Biol. Chem., June 19, 1998; 273(25): 15358 - 15365. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |