JBC Transcription and Nuclear Factor Monoclonals

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Volume 272, Number 47, Issue of November 21, 1997 pp. 29801-29809
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

Identification of a Novel Transcriptional Regulatory Element Common to the p53 and Interferon Regulatory Factor 1 Genes

(Received for publication, June 13, 1997, and in revised form, August 14, 1997)

Christophe Lallemand , Mahasti Bayat-Sarmadi , Brigitte Blanchard and Michael G. Tovey

From the Laboratory of Viral Oncology, CNRS, UPR 9045, IFC-1, 7, Rue Guy Moquet, 94801 Villejuif Cedex, France

The promoter regions of both the interferon regulatory factor (IRF1) and p53 antioncogenes contain a previously unidentified sequence denoted IRF1 p53 common sequence (IPCS), which markedly increases the transcriptional activity of a reporter gene placed under the control of an heterologous promoter in transfected U937 cells. In contrast, transfection of U937 cells with reporter vectors containing p53 and IRF1 promoters with mutated IPCS sites resulted in a 4-fold reduction in the constitutive expression of those two genes. The transcriptional activity of IPCS is strictly correlated with the binding of a novel nuclear factor, IPCS-binding factor (IPCS-BF). IPCS-BF, which is composed of a single polypeptide of 26 kDa, is present constitutively in nuclear extracts of both U937 cells and peripheral blood mononuclear cells from healthy donors. The finding that the pattern of binding of IPCS-BF to the IPCS is unlike that of any known transcription factor and that the IPCS sequence does not exhibit any significant homology with any known binding site present in the data base, strongly suggest that IPCS-BF is a novel transcription factor which, by virtue of this ability to regulate the expression of the p53 and IRF1 genes, could play a central role in the control of cell proliferation and/or apoptosis.


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