| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, June 6, 1997, and in revised form, August 12, 1997)
From the Division of Drug Metabolism, Faculty of Pharmaceutical
Sciences, Hokkaido University, N12W6, Kita-ku, Sapporo,
Hokkaido 060, Japan
A xenobiotic-responsive element (XRE)-binding
factor(s) other than the AhR·Arnt complex was found to inhibit the
transcription of CYP1A1 gene in the liver from adult
rabbits, known to be nonresponsive to CYP1A1 inducers. The constitutive
factor(s) in liver nuclear extracts bound to the core sequence of XRE.
The binding was eliminated by the presence of an excess amount of the
AhR·Arnt complex synthesized in vitro. To identify the
constitutive factor(s), a sequence similar to rabbit XRE was sought. It
was found that the sequence of rabbit XRE overlapped with that of the
upstream stimulatory factor 1 (USF1)-binding site in the mouse
metallothionein I promoter. In fact, a super shift assay using a
specific antibody against human USF1 indicated that USF1 was capable of
binding to rabbit XRE. Additionally, the AhR·Arnt-mediated activation
of XRE-TK/Luc reporter gene in RK13 cells was blocked by the
transfection with a USF1 expression vector with the amounts of the
expression vector transfected. These results indicate that the XRE of
the rabbit CYP1A1 gene is recognized by the basic
helix-loop-helix proteins to regulate the expression of
CYP1A1 in both an agonistic (AhR·Arnt) and an antagonistic (USF1) manner.
Volume 272, Number 48,
Issue of November 28, 1997
pp. 30025-30031
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
Inhibition of the Transcription of CYP1A1 Gene by the
Upstream Stimulatory Factor 1 in Rabbits
COMPETITIVE BINDING OF USF1 WITH AhR·Arnt COMPLEX
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  H. Utsunomiya, Y.-H. Cheng, Z. Lin, S. Reierstad, P. Yin, E. Attar, Q. Xue, G. Imir, S. Thung, E. Trukhacheva, et al. Upstream Stimulatory Factor-2 Regulates Steroidogenic Factor-1 Expression in Endometriosis Mol. Endocrinol., April 1, 2008; 22(4): 904 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Y. Dimova and T. Kietzmann Cell Type-dependent Regulation of the Hypoxia-responsive Plasminogen Activator Inhibitor-1 Gene by Upstream Stimulatory Factor-2 J. Biol. Chem., February 3, 2006; 281(5): 2999 - 3005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Jiang and C. R. Mendelson O2 Enhancement of Human Trophoblast Differentiation and hCYP19 (Aromatase) Gene Expression Are Mediated by Proteasomal Degradation of USF1 and USF2 Mol. Cell. Biol., October 15, 2005; 25(20): 8824 - 8833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. V. Sun, D. R. Boverhof, L. D. Burgoon, M. R. Fielden, and T. R. Zacharewski Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences Nucleic Acids Res., August 24, 2004; 32(15): 4512 - 4523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Hough and J. Piatigorsky Preferential Transcription of Rabbit Aldh1a1 in the Cornea: Implication of Hypoxia-Related Pathways Mol. Cell. Biol., February 1, 2004; 24(3): 1324 - 1340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Jiang and C. R. Mendelson USF1 and USF2 Mediate Inhibition of Human Trophoblast Differentiation and CYP19 Gene Expression by Mash-2 and Hypoxia Mol. Cell. Biol., September 1, 2003; 23(17): 6117 - 6128. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-P. Yang, L. A. Freeman, C. L. Knapper, M. J. A. Amar, A. Remaley, H. B. Brewer Jr., and S. Santamarina-Fojo The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene J. Lipid Res., February 1, 2002; 43(2): 297 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pan, T. A. Black, Q. Shi, C. A. Jones, N. Petrovic, J. Loudon, C. Kane, C. D. Sigmund, and K. W. Gross Critical Roles of a Cyclic AMP Responsive Element and an E-box in Regulation of Mouse Renin Gene Expression J. Biol. Chem., November 30, 2001; 276(49): 45530 - 45538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Handschin, M. Podvinec, R. Looser, R. Amherd, and U. A. Meyer Multiple Enhancer Units Mediate Drug Induction of CYP2H1 by Xenobiotic-Sensing Orphan Nuclear Receptor Chicken Xenobiotic Receptor Mol. Pharmacol., October 1, 2001; 60(4): 681 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Samoylenko, U. Roth, K. Jungermann, and T. Kietzmann The upstream stimulatory factor-2a inhibits plasminogen activator inhibitor-1 gene expression by binding to a promoter element adjacent to the hypoxia-inducible factor-1 binding site Blood, May 1, 2001; 97(9): 2657 - 2666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Kingsley-Kallesen, D. Kelly, and A. Rizzino Transcriptional Regulation of the Transforming Growth Factor-beta 2 Promoter by cAMP-responsive Element-binding Protein (CREB) and Activating Transcription Factor-1 (ATF-1) Is Modulated by Protein Kinases and the Coactivators p300 and CREB-binding Protein J. Biol. Chem., November 26, 1999; 274(48): 34020 - 34028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Chen and K. S. Ramos A CCAAT/Enhancer-binding Protein Site within Antioxidant/Electrophile Response Element Along with CREB-binding Protein Participate in the Negative Regulation of Rat GST-Ya Gene in Vascular Smooth Muscle Cells J. Biol. Chem., August 25, 2000; 275(35): 27366 - 27376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Saito, Y. Takahashi, H. Hashimoto, and T. Kamataki Novel Transcriptional Regulation of the Human CYP3A7 Gene by Sp1 and Sp3 through Nuclear Factor kappa B-like Element J. Biol. Chem., October 5, 2001; 276(41): 38010 - 38022. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
