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(Received for publication, October 9, 1997)
,
,
and
From the Interleukin-6 (IL-6) and glucocorticoids are
important mediators of inflammatory and immunological responses.
Glucocorticoids are known to synergistically enhance IL-6-mediated
cellular responses. We now show that IL-6 also has a synergistic effect
upon glucocorticoid signaling. In particular, IL-6-activated STAT3
associates with ligand-bound glucocorticoid receptor to form a
transactivating/signaling complex, which can function through either an
IL-6-responsive element or a glucocorticoid-responsive element. These
findings reveal a new level of interaction between these two crucial
signaling cascades and indicate that activated STAT3 can also act as a
transcriptional co-activator without direct association with its DNA
binding motif.
Department of Cell Biology and the
§ Department of Pediatrics, Pulmonary Division, University
of Alabama at Birmingham, Birmingham, Alabama 35294
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