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Volume 272, Number 5, Issue of January 31, 1997 pp. 2615-2619
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.

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Isolation of the Mouse Aldose Reductase Promoter and Identification of a Tonicity-responsive Element

(Received for publication, May 28, 1996, and in revised form, August 12, 1996)

From the Laboratoire de Reproduction et Développement, CNRS, URA 1940, Université Blaise Pascal-Clermont-Ferrand II, 63177 Aubiere Cédex, France

Aldose reductase (AR; EC 1.1.1.21) is an oxidoreductase that catalyzes the NADPH-dependent conversion of glucose to sorbitol, the first step of the polyol pathway. AR is of great interest due to its implication in the etiology of diabetic complications. In renal medullary cells, AR also plays an osmoregulatory role by accumulating sorbitol to maintain the intracellular osmotic balance during antidiuresis. We have previously cloned the AR cDNA from mouse kidney, and we report here the isolation of the mouse AR gene promoter. Transient transfection of chloramphenicol acetyltransferase reporter constructs containing various 5-flanking regions of the mouse AR gene in CV1 cells led to the identification of a sequence spanning base pairs 1053 to 1040, required for an enhancer activity in hypertonic compared with isotonic cell culture conditions. This sequence is similar to the tonicity-responsive element first characterized in the betaine--aminobutyric acid transporter promoter.

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