| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Volume 272, Number 51, Issue of December 19, 1997 pp. 32019-32024
(Received for publication, July 30, 1997, and in revised form, September 18, 1997)
,
From the PICK1 is a protein kinase C (PKC) 
Department of Molecular Endocrinology,
GlaxoWellcome, Research Triangle Park, North Carolina 27709 and the
¶ Department of Molecular Biology and Oncology, The University of
Texas, Southwestern Medical Center at Dallas, Hamon Center for Basic
Cancer Research, Dallas, Texas 75235-9148
-binding
protein initially identified using the yeast two-hybrid system. Here we
report that PICK1 contains a PDZ domain that interacts specifically
with a previously unidentified PDZ-binding domain (QSAV) at the extreme COOH terminus of PKC and that mutation of a putative
carboxylate-binding loop within the PICK1 PDZ domain abolishes this
interaction. The PDZ-binding domain in PKC is absent from other PKC
isoforms that do not interact with PICK1. We also demonstrate that
PICK1 can homooligomerize through sequences that are distinct from the
carboxylate-binding loop, suggesting that self-association and PKC
binding are not mutually exclusive. A Caenorhabditis
elegans PICK1-like protein is also able to bind to PKC,
suggesting a conservation of function through evolution. Association of
PKC with PICK1 provides a potential mechanism for the selective
targeting of PKC to unique subcellular sites.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  H. Stensman and C. Larsson Identification of Acidic Amino Acid Residues in the Protein Kinase C{alpha} V5 Domain That Contribute to Its Insensitivity to Diacylglycerol J. Biol. Chem., September 28, 2007; 282(39): 28627 - 28638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Joch, A. R. Ase, C. X.-Q. Chen, P. A. MacDonald, M. Kontogiannea, A. T. Corera, A. Brice, P. Seguela, and E. A. Fon Parkin-mediated Monoubiquitination of the PDZ Protein PICK1 Regulates the Activity of Acid-sensing Ion Channels Mol. Biol. Cell, August 1, 2007; 18(8): 3105 - 3118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Sossin Isoform specificity of protein kinase Cs in synaptic plasticity Learn. Mem., April 2, 2007; 14(4): 236 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Elkins, E. Papagrigoriou, G. Berridge, X. Yang, C. Phillips, C. Gileadi, P. Savitsky, and D. A. Doyle Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions Protein Sci., April 1, 2007; 16(4): 683 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Yeong, Y. Zhu, D. Smith, C. Verma, W. G. Lim, B. J. Tan, Q. T. Li, N. S. Cheung, M. Cai, Y.-Z. Zhu, et al. The Last 10 Amino Acid Residues beyond the Hydrophobic Motif Are Critical for the Catalytic Competence and Function of Protein Kinase C{alpha} J. Biol. Chem., October 13, 2006; 281(41): 30768 - 30781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yawata, H. Tsuchida, M. Kengaku, and T. Hirano Membrane-proximal region of glutamate receptor delta2 subunit is critical for long-term depression and interaction with protein interacting with C kinase 1 in a cerebellar Purkinje neuron. J. Neurosci., April 5, 2006; 26(14): 3626 - 3633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Bartoe, W. L. McKenna, T. K. Quan, B. K. Stafford, J. A. Moore, J. Xia, K. Takamiya, R. L. Huganir, and L. Hinck Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction. J. Neurosci., March 22, 2006; 26(12): 3192 - 3205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Madsen, T. Beuming, M. Y. Niv, C.-w. Chang, K. K. Dev, H. Weinstein, and U. Gether Molecular Determinants for the Complex Binding Specificity of the PDZ Domain in PICK1 J. Biol. Chem., May 27, 2005; 280(21): 20539 - 20548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Shin, F. Shen, and J. R. Huguenard Polyamines Modulate AMPA Receptor-Dependent Synaptic Responses in Immature Layer V Pyramidal Neurons J Neurophysiol, May 1, 2005; 93(5): 2634 - 2643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Dev, S. Nakanishi, and J. M. Henley The PDZ Domain of PICK1 Differentially Accepts Protein Kinase C-{alpha} and GluR2 as Interacting Ligands J. Biol. Chem., October 1, 2004; 279(40): 41393 - 41397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bjerggaard, J. U. Fog, H. Hastrup, K. Madsen, C. J. Loland, J. A. Javitch, and U. Gether Surface Targeting of the Dopamine Transporter Involves Discrete Epitopes in the Distal C Terminus But Does Not Require Canonical PDZ Domain Interactions J. Neurosci., August 4, 2004; 24(31): 7024 - 7036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. H. Lee, J. O. You, K. S. Ha, D. S. Bae, P.-G. Suh, S. G. Rhee, and Y. S. Bae AHNAK-mediated Activation of Phospholipase C-{gamma}1 through Protein Kinase C J. Biol. Chem., June 18, 2004; 279(25): 26645 - 26653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Terashima, L. Cotton, K. K. Dev, G. Meyer, S. Zaman, F. Duprat, J. M. Henley, G. L. Collingridge, and J. T. R. Isaac Regulation of Synaptic Strength and AMPA Receptor Subunit Composition by PICK1 J. Neurosci., June 9, 2004; 24(23): 5381 - 5390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Deval, M. Salinas, A. Baron, E. Lingueglia, and M. Lazdunski ASIC2b-dependent Regulation of ASIC3, an Essential Acid-sensing Ion Channel Subunit in Sensory Neurons via the Partner Protein PICK-1 J. Biol. Chem., May 7, 2004; 279(19): 19531 - 19539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Gonzalez and M. B. Robinson Protein KINASE C-Dependent Remodeling of Glutamate Transporter Function Mol. Interv., February 1, 2004; 4(1): 48 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Williams, S. C.-Y. Wu, W. L. McKenna, and L. Hinck Surface Expression of the Netrin Receptor UNC5H1 Is Regulated through a Protein Kinase C-Interacting Protein/Protein Kinase-Dependent Mechanism J. Neurosci., December 10, 2003; 23(36): 11279 - 11288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Seidenman, J. P. Steinberg, R. Huganir, and R. Malinow Glutamate Receptor Subunit 2 Serine 880 Phosphorylation Modulates Synaptic Transmission and Mediates Plasticity in CA1 Pyramidal Cells J. Neurosci., October 8, 2003; 23(27): 9220 - 9228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-L. Wang, S.-F. Yeh, Y.-I Chang, S.-F. Hsiao, W.-N. Lian, C.-H. Lin, C.-Y. F. Huang, and W.-J. Lin PICK1, an Anchoring Protein That Specifically Targets Protein Kinase C{alpha} to Mitochondria Selectively upon Serum Stimulation in NIH 3T3 Cells J. Biol. Chem., September 26, 2003; 278(39): 37705 - 37712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Nourry, S. G. N. Grant, and J.-P. Borg PDZ Domain Proteins: Plug and Play! Sci. Signal., April 22, 2003; 2003(179): re7 - re7. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-T. Lim, R. L. Longley, J. R. Couchman, and A. Woods Direct Binding of Syndecan-4 Cytoplasmic Domain to the Catalytic Domain of Protein Kinase Calpha (PKCalpha ) Increases Focal Adhesion Localization of PKCalpha J. Biol. Chem., April 11, 2003; 278(16): 13795 - 13802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Schuh, S. Uldrijan, S. Gambaryan, N. Roethlein, and L. Neyses Interaction of the Plasma Membrane Ca2+ Pump 4b/CI with the Ca2+/Calmodulin-dependent Membrane-associated Kinase CASK J. Biol. Chem., March 7, 2003; 278(11): 9778 - 9783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baron, E. Deval, M. Salinas, E. Lingueglia, N. Voilley, and M. Lazdunski Protein Kinase C Stimulates the Acid-sensing Ion Channel ASIC2a via the PDZ Domain-containing Protein PICK1 J. Biol. Chem., December 20, 2002; 277(52): 50463 - 50468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Todt, B. Hu, A. Punturieri, J. Sonstein, T. Polak, and J. L. Curtis Activation of Protein Kinase C beta II by the Stereo-specific Phosphatidylserine Receptor Is Required for Phagocytosis of Apoptotic Thymocytes by Resident Murine Tissue Macrophages J. Biol. Chem., September 20, 2002; 277(39): 35906 - 35914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Lim, D. D. Hall, and J. W. Hell Selectivity and Promiscuity of the First and Second PDZ Domains of PSD-95 and Synapse-associated Protein 102 J. Biol. Chem., June 7, 2002; 277(24): 21697 - 21711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hirbec, O. Perestenko, A. Nishimune, G. Meyer, S. Nakanishi, J. M. Henley, and K. K. Dev The PDZ Proteins PICK1, GRIP, and Syntenin Bind Multiple Glutamate Receptor Subtypes. ANALYSIS OF PDZ BINDING MOTIFS J. Biol. Chem., May 3, 2002; 277(18): 15221 - 15224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Hung and M. Sheng PDZ Domains: Structural Modules for Protein Complex Assembly J. Biol. Chem., February 15, 2002; 277(8): 5699 - 5702. [Full Text] [PDF]
|
|
|
|
 |
|
 I. Eude, E. Dallot, F. Ferre, and M. Breuiller-Fouche Protein Kinase C{alpha} Is Required for Endothelin-1-Induced Proliferation of Human Myometrial Cells Biol Reprod, January 1, 2002; 66(1): 44 - 49. [Abstract] [Full Text]
|
|
|
|
|
|
J. Perroy, G. J. Gutierrez, V. Coulon, J. Bockaert, J.-P. Pin, and L. Fagni The C Terminus of the Metabotropic Glutamate Receptor Subtypes 2 and 7 Specifies the Receptor Signaling Pathways J. Biol. Chem., November 30, 2001; 276(49): 45800 - 45805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. S. Lin, A. C. Arai, Z. Wang, H.-P. Nothacker, and O. Civelli The Carboxyl Terminus of the Prolactin-Releasing Peptide Receptor Interacts with PDZ Domain Proteins Involved in alpha -Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Clustering Mol. Pharmacol., November 1, 2001; 60(5): 916 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Iwakura, T. Nagano, M. Kawamura, H. Horikawa, K. Ibaraki, N. Takei, and H. Nawa N-Methyl-D-aspartate-induced alpha -Amino-3-hydroxy-5-methyl-4-isoxazoleproprionic Acid (AMPA) Receptor Down-regulation Involves Interaction of the Carboxyl Terminus of GluR2/3 with Pick1. LIGAND-BINDING STUDIES USING Sindbis VECTORS CARRYING AMPA RECEPTOR DECOYS J. Biol. Chem., October 19, 2001; 276(43): 40025 - 40032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Perez, L. Khatri, C. Chang, S. Srivastava, P. Osten, and E. B. Ziff PICK1 Targets Activated Protein Kinase C{alpha} to AMPA Receptor Clusters in Spines of Hippocampal Neurons and Reduces Surface Levels of the AMPA-Type Glutamate Receptor Subunit 2 J. Neurosci., August 1, 2001; 21(15): 5417 - 5428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Svensson, R. Zeidman, U. Trollér, A. Schultz, and C. Larsson Protein Kinase C {beta}I Is Implicated in the Regulation of Neuroblastoma Cell Growth and Proliferation Cell Growth Differ., December 1, 2000; 11(12): 641 - 648. [Abstract] [Full Text]
|
|
|
|
|
|
K. K. Dev, Y. Nakajima, J. Kitano, S. P. Braithwaite, J. M. Henley, and S. Nakanishi PICK1 Interacts with and Regulates PKC Phosphorylation of mGLUR7 J. Neurosci., October 1, 2000; 20(19): 7252 - 7257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Chung, J. Xia, R. H. Scannevin, X. Zhang, and R. L. Huganir Phosphorylation of the AMPA Receptor Subunit GluR2 Differentially Regulates Its Interaction with PDZ Domain-Containing Proteins J. Neurosci., October 1, 2000; 20(19): 7258 - 7267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. RON and M. G. KAZANIETZ New insights into the regulation of protein kinase C and novel phorbol ester receptors FASEB J, October 1, 1999; 13(13): 1658 - 1676. [Abstract] [Full Text]
|
|
|
|
|
|
Q. Zhou, P. Ruiz-Lozano, M. E. Martone, and J. Chen Cypher, a Striated Muscle-restricted PDZ and LIM Domain-containing Protein, Binds to alpha -Actinin-2 and Protein Kinase C J. Biol. Chem., July 9, 1999; 274(28): 19807 - 19813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-g. Sun and S. A. Rotenberg Overexpression of Protein Kinase C{{alpha}} in MCF-10A Human Breast Cells Engenders Dramatic Alterations in Morphology, Proliferation, and Motility Cell Growth Differ., May 1, 1999; 10(5): 343 - 352. [Abstract] [Full Text]
|
|
|
|
|
|
M. Hasegawa, A. Cuenda, M. G. Spillantini, G. M. Thomas, V. Buee-Scherrer, P. Cohen, and M. Goedert Stress-activated Protein Kinase-3 Interacts with the PDZ Domain of alpha 1-Syntrophin. A MECHANISM FOR SPECIFIC SUBSTRATE RECOGNITION J. Biol. Chem., April 30, 1999; 274(18): 12626 - 12631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Deretic, S. Schmerl, P. A. Hargrave, A. Arendt, and J. H. McDowell Regulation of sorting and post-Golgi trafficking of rhodopsin by its C-terminal sequence QVS(A)PA PNAS, September 1, 1998; 95(18): 10620 - 10625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Gokmen-Polar and A. P. Fields Mapping of a Molecular Determinant for Protein Kinase C beta II Isozyme Function J. Biol. Chem., August 7, 1998; 273(32): 20261 - 20266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chapline, J. Cottom, H. Tobin, J. Hulmes, J. Crabb, and S. Jaken A Major, Transformation-sensitive PKC-binding Protein Is Also a PKC Substrate Involved in Cytoskeletal Remodeling J. Biol. Chem., July 31, 1998; 273(31): 19482 - 19489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-I. Hwang, K. Heo, K.-J. Shin, E. Kim, C.-H. C. Yun, S. H. Ryu, H.-S. Shin, and P.-G. Suh Regulation of Phospholipase C-beta 3 Activity by Na+/H+ Exchanger Regulatory Factor 2 J. Biol. Chem., May 26, 2000; 275(22): 16632 - 16637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Jaulin-Bastard, H. Saito, A. Le Bivic, V. Ollendorff, S. Marchetto, D. Birnbaum, and J.-P. Borg The ERBB2/HER2 Receptor Differentially Interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 Domain Proteins J. Biol. Chem., April 27, 2001; 276(18): 15256 - 15263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Boudin and A. M. Craig Molecular Determinants for PICK1 Synaptic Aggregation and mGluR7a Receptor Coclustering. ROLE OF THE PDZ, COILED-COIL, AND ACIDIC DOMAINS J. Biol. Chem., August 3, 2001; 276(32): 30270 - 30276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Duggan, J. Garcia-Anoveros, and D. P. Corey The PDZ Domain Protein PICK1 and the Sodium Channel BNaC1 Interact and Localize at Mechanosensory Terminals of Dorsal Root Ganglion Neurons and Dendrites of Central Neurons J. Biol. Chem., February 8, 2002; 277(7): 5203 - 5208. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
