| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
(Received for publication, August 2, 1996, and in revised form, November 7, 1996)
From SUGEN, Inc., Redwood City, California 94063
Cadherins are transmembrane receptors with an
extracellular domain that participates in homophilic cell to cell
adhesion and a cytoplasmic domain that associates with proteins called
catenins. Cadherin-mediated adhesion as well as adhesion-independent
functions for catenins play important roles in differentiation,
development, and malignant transformation. Mechanisms that regulate
steady-state catenin levels and cadherin-catenin complex stability are
poorly understood, but activities of both the Wnt-1 proto-oncogene and tyrosine kinases are implicated. Here I define, at the biochemical level, distinct mechanisms that modulate steady-state catenin levels.
Increased cadherin expression, providing more catenin binding sites,
leads to selective stabilization of the cadherin-associated population
of
Volume 272, Number 7,
Issue of February 14, 1997
pp. 4536-4543
©1997 by The American Society for Biochemistry and Molecular Biology, Inc.
DIFFERENTIAL EFFECTS OF Wnt-1 AND v-Src
- and 
-catenin, but not p120cas. In contrast,
expression of Wnt-1 leads primarily to increased stability of the
uncomplexed pool of -catenin without effect on p120cas.
Significantly, the Wnt-1-induced stabilization of uncomplexed -catenin is independent of cadherin expression. Transformation by
v-Src does not disrupt the catenin-cadherin complex despite the
phosphorylation of E-cadherin and -catenin on tyrosine. In contrast
to the effects of Wnt-1, v-Src does not modulate the uncomplexed
population of -catenin. p120cas is phosphorylated on
tyrosine by v-Src, and this is accompanied by a significant decrease in
the level of uncomplexed p120cas as well as a change in
behavior of p120cas upon biochemical fractionation. Taken
together these data suggest that p120cas and -catenin are
regulated independently.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Tominaga, Y. Fukunaga, E. Abelardo, and A. Nagafuchi Defining the function of beta-catenin tyrosine phosphorylation in cadherin-mediated cell-cell adhesion. Genes Cells, January 1, 2008; 13(1): 67 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Gastaldi, P. Bonvini, F. Sartori, A. Marrone, A. Iolascon, and A. Rosolen Plakoglobin is differentially expressed in alveolar and embryonal rhabdomyosarcoma and is regulated by DNA methylation and histone acetylation Carcinogenesis, September 1, 2006; 27(9): 1758 - 1767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Thoumine, M. Lambert, R.-M. Mege, and D. Choquet Regulation of N-Cadherin Dynamics at Neuronal Contacts by Ligand Binding and Cytoskeletal Coupling Mol. Biol. Cell, February 1, 2006; 17(2): 862 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Karni, Y. Gus, Y. Dor, O. Meyuhas, and A. Levitzki Active Src Elevates the Expression of {beta}-Catenin by Enhancement of Cap-Dependent Translation Mol. Cell. Biol., June 15, 2005; 25(12): 5031 - 5039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rochat, A. Fernandez, M. Vandromme, J.-P. Moles, T. Bouschet, G. Carnac, and N. J. C. Lamb Insulin and Wnt1 Pathways Cooperate to Induce Reserve Cell Activation in Differentiation and Myotube Hypertrophy Mol. Biol. Cell, October 1, 2004; 15(10): 4544 - 4555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mehta p120: the guardian of endothelial junctional integrity Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1140 - L1142. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ohkubo and M. Ozawa The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation J. Cell Sci., May 1, 2004; 117(9): 1675 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-T. Lin, M.-L. Yen, C.-Y. Lin, and M.-L. Kuo Inhibition of Vascular Endothelial Growth Factor-Induced Angiogenesis by Resveratrol through Interruption of Src-Dependent Vascular Endothelial Cadherin Tyrosine Phosphorylation Mol. Pharmacol., November 1, 2003; 64(5): 1029 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. DeBellefeuille, L. Hermo, M. Gregory, J. Dufresne, and D. G. Cyr Catenins in the Rat Epididymis: Their Expression and Regulation in Adulthood and during Postnatal Development Endocrinology, November 1, 2003; 144(11): 5040 - 5049. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. P.Y. Lee, D. Mruk, W. M. Lee, and C. Y. Cheng Is the Cadherin/Catenin Complex a Functional Unit of Cell-Cell Actin-Based Adherens Junctions in the Rat Testis? Biol Reprod, February 1, 2003; 68(2): 489 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Taddei, P. Chiarugi, P. Cirri, F. Buricchi, T. Fiaschi, E. Giannoni, D. Talini, G. Cozzi, L. Formigli, G. Raugei, et al. {beta}-Catenin Interacts with Low-Molecular-Weight Protein Tyrosine Phosphatase Leading to Cadherin-mediated Cell-Cell Adhesion Increase Cancer Res., November 15, 2002; 62(22): 6489 - 6499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. LIU, K. L. SCHAPHORST, A. D. VERIN, K. JACOBS, A. BIRUKOVA, R. M. DAY, N. BOGATCHEVA, D. P. BOTTARO, and J. G. N. GARCIA Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3{beta} FASEB J, July 1, 2002; 16(9): 950 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Kaplan, T. E. Meigs, and P. J. Casey Distinct Regions of the Cadherin Cytoplasmic Domain Are Essential for Functional Interaction with Galpha 12 and beta -Catenin J. Biol. Chem., November 16, 2001; 276(47): 44037 - 44043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Danilkovitch-Miagkova, A. Miagkov, A. Skeel, N. Nakaigawa, B. Zbar, and E. J. Leonard Oncogenic Mutants of RON and MET Receptor Tyrosine Kinases Cause Activation of the {beta}-Catenin Pathway Mol. Cell. Biol., September 1, 2001; 21(17): 5857 - 5868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Hamm-Alvarez, A. Chang, Y. Wang, G. Jerdeva, H. H. Lin, K.-J. Kim, and D. K. Ann Etk/Bmx activation modulates barrier function in epithelial cells Am J Physiol Cell Physiol, June 1, 2001; 280(6): C1657 - C1668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Sellin, S. Umar, J. Xiao, and A. P. Morris Increased {beta}-Catenin Expression and Nuclear Translocation Accompany Cellular Hyperproliferation in Vivo Cancer Res., April 1, 2001; 61(7): 2899 - 2906. [Abstract] [Full Text]
|
|
|
|
|
|
M Ozawa and T Ohkubo Tyrosine phosphorylation of p120(ctn) in v-Src transfected L cells depends on its association with E-cadherin and reduces adhesion activity J. Cell Sci., January 2, 2001; 114(3): 503 - 512. [Abstract] [PDF]
|
|
|
|
|
|
I Grosheva, M Shtutman, M Elbaum, and A. Bershadsky p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion J. Cell Sci., January 2, 2001; 114(4): 695 - 707. [Abstract] [PDF]
|
|
|
|
|
|
C. Y. Sasaki, H. Lin, P. J. Morin, and D. L. Longo Truncation of the Extracellular Region Abrogrates Cell Contact but Retains the Growth-suppressive Activity of E-cadherin Cancer Res., December 1, 2000; 60(24): 7057 - 7065. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. P. Playford, D. Bicknell, W. F. Bodmer, and V. M. Macaulay Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta -catenin PNAS, October 12, 2000; (2000) 210394297. [Abstract] [Full Text]
|
|
|
|
|
|
M. Lecuit, R. Hurme, J. Pizarro-Cerda, H. Ohayon, B. Geiger, and P. Cossart A role for alpha - and beta -catenins in bacterial uptake PNAS, August 29, 2000; 97(18): 10008 - 10013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Noren, B. P. Liu, K. Burridge, and B. Kreft p120 Catenin Regulates the Actin Cytoskeleton via Rho Family GTPases J. Cell Biol., August 7, 2000; 150(3): 567 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Ukropec, M. K. Hollinger, S. M. Salva, and M. J. Woolkalis SHP2 Association with VE-Cadherin Complexes in Human Endothelial Cells Is Regulated by Thrombin J. Biol. Chem., February 25, 2000; 275(8): 5983 - 5986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Thoreson, P. Z. Anastasiadis, J. M. Daniel, R. C. Ireton, M. J. Wheelock, K. R. Johnson, D. K. Hummingbird, and A. B. Reynolds Selective Uncoupling of p120ctn from E-cadherin Disrupts Strong Adhesion J. Cell Biol., January 10, 2000; 148(1): 189 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Lambert, F Padilla, and R. Mege Immobilized dimers of N-cadherin-Fc chimera mimic cadherin-mediated cell contact formation: contribution of both outside-in and inside-out signals J. Cell Sci., January 6, 2000; 113(12): 2207 - 2219. [Abstract] [PDF]
|
|
|
|
|
|
M Cozzolino, B Giovannone, A Serafino, K Knudsen, A Levi, S Alema, and A Salvatore Activation of TrkA tyrosine kinase in embryonal carcinoma cells promotes cell compaction, independently of tyrosine phosphorylation of catenins J. Cell Sci., January 5, 2000; 113(9): 1601 - 1610. [Abstract] [PDF]
|
|
|
|
|
|
P. Anastasiadis and A. Reynolds The p120 catenin family: complex roles in adhesion, signaling and cancer J. Cell Sci., January 4, 2000; 113(8): 1319 - 1334. [Abstract] [PDF]
|
|
|
|
|
|
D. W. Owens, G. W. McLean, A. W. Wyke, C. Paraskeva, E. K. Parkinson, M. C. Frame, and V. G. Brunton The Catalytic Activity of the Src Family Kinases Is Required to Disrupt Cadherin-dependent Cell-Cell Contacts Mol. Biol. Cell, January 1, 2000; 11(1): 51 - 64. [Abstract] [Full Text]
|
|
|
|
|
|
J. Luo, D. M. Lubaroff, and M. J. C. Hendrix Suppression of Prostate Cancer Invasive Potential and Matrix Metalloproteinase Activity by E-Cadherin Transfection Cancer Res., August 1, 1999; 59(15): 3552 - 3556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Kang, S. Soriano, M. P. Frosch, T. Collins, S. Naruse, S. S. Sisodia, G. Leibowitz, F. Levine, and E. H. Koo Presenilin 1 Facilitates the Constitutive Turnover of beta -Catenin: Differential Activity of Alzheimer's Disease-Linked PS1 Mutants in the beta -Catenin-Signaling Pathway J. Neurosci., June 1, 1999; 19(11): 4229 - 4237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Pötter, C. Bergwitz, and G. Brabant The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues Endocr. Rev., April 1, 1999; 20(2): 207 - 239. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. Torres, H. Eldar-Finkelman, E. G. Krebs, and R. T. Moon Regulation of Ribosomal S6 Protein Kinase-p90rsk, Glycogen Synthase Kinase 3, and beta -Catenin in Early Xenopus Development Mol. Cell. Biol., February 1, 1999; 19(2): 1427 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Dennis, M Aikawa, W Szeto, P. d'Amore, and J Papkoff A secreted frizzled related protein, FrzA, selectively associates with Wnt-1 protein and regulates wnt-1 signaling J. Cell Sci., January 11, 1999; 112(21): 3815 - 3820. [Abstract] [PDF]
|
|
|
|
|
|
S Orsulic, O Huber, H Aberle, S Arnold, and R Kemler E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation J. Cell Sci., January 4, 1999; 112(8): 1237 - 1245. [Abstract] [PDF]
|
|
|
|
|
|
R. Rosato, J. M. Veltmaat, J. Groffen, and N. Heisterkamp Involvement of the Tyrosine Kinase Fer in Cell Adhesion Mol. Cell. Biol., October 1, 1998; 18(10): 5762 - 5770. [Abstract] [Full Text]
|
|
|
|
|
|
B. St. Croix, C. Sheehan, J. W. Rak, V. A. Florenes, J. M. Slingerland, and R. S. Kerbel E-Cadherin-dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1 J. Cell Biol., July 27, 1998; 142(2): 557 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Calautti, S. Cabodi, P. L. Stein, M. Hatzfeld, N. Kedersha, and G. Paolo Dotto Tyrosine Phosphorylation and Src Family Kinases Control Keratinocyte Cell-Cell Adhesion J. Cell Biol., June 15, 1998; 141(6): 1449 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Okada, J. W. Rak, B. St. Croix, B. Lieubeau, M. Kaya, L. Roncari, S. Shirasawa, T. Sasazuki, and R. S. Kerbel Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells PNAS, March 31, 1998; 95(7): 3609 - 3614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Esser, M. Lampugnani, M Corada, E Dejana, and W Risau Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells J. Cell Sci., January 7, 1998; 111(13): 1853 - 1865. [Abstract] [PDF]
|
|
|
|
|
|
F. Lucas, R. Goold, P. Gordon-Weeks, and P. Salinas Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium J. Cell Sci., January 5, 1998; 111(10): 1351 - 1361. [Abstract] [PDF]
|
|
|
|
|
|
Z Li, W. Gallin, G Lauzon, and M Pasdar L-CAM expression induces fibroblast-epidermoid transition in squamous carcinoma cells and down-regulates the endogenous N-cadherin J. Cell Sci., January 4, 1998; 111(7): 1005 - 1019. [Abstract] [PDF]
|
|
|
|
|
|
R. N.M. Sehgal, B. M. Gumbiner, and L. F. Reichardt Antagonism of Cell Adhesion by an alpha -Catenin Mutant, and of the Wnt-signaling Pathway by alpha -Catenin in Xenopus Embryos J. Cell Biol., November 17, 1997; 139(4): 1033 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lampugnani, M Corada, P Andriopoulou, S Esser, W Risau, and E Dejana Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells J. Cell Sci., January 9, 1997; 110(17): 2065 - 2077. [Abstract] [PDF]
|
|
|
|
|
|
M. P. Fadel, M. Szewczenko-Pawlikowski, P. Leclerc, E. Dziak, J. M. Symonds, O. Blaschuk, M. Michalak, and M. Opas Calreticulin Affects beta -Catenin-associated Pathways J. Biol. Chem., July 13, 2001; 276(29): 27083 - 27089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Mariner, P. Anastasiadis, H. Keilhack, F.-D. Bohmer, J. Wang, and A. B. Reynolds Identification of Src Phosphorylation Sites in the Catenin p120ctn J. Biol. Chem., July 20, 2001; 276(30): 28006 - 28013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Song, D. J. Sussman, and D. C. Seldin Endogenous Protein Kinase CK2 Participates in Wnt Signaling in Mammary Epithelial Cells J. Biol. Chem., July 28, 2000; 275(31): 23790 - 23797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Playford, D. Bicknell, W. F. Bodmer, and V. M. Macaulay Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta -catenin PNAS, October 24, 2000; 97(22): 12103 - 12108. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
