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Vol. 273, Issue 1, 23-27, January 2, 1998
§,,, and
From the ADP-ribosylation factors (ARFs) constitute a
family of small monomeric GTPases. ARFs 1 and 3 function in the
recruitment of coat proteins to membranes of the Golgi apparatus,
whereas ARF6 is localized to the plasma membrane, where it appears to
modulate both the assembly of the actin cytoskeleton and endocytosis.
Like other GTPases, ARF activation is facilitated by specific guanine nucleotide exchange factors (GEFs). ARNO (ARF nucleotide-binding site
opener) is a member of a growing family of ARF-GEFs that share a
common, tripartite structure consisting of an N-terminal coiled-coil
domain, a central domain with homology to the yeast protein Sec7p, and
a C-terminal pleckstrin homology domain. Recently, ARNO and its close
homologue cytohesin-1 were found to catalyze in vitro
nucleotide exchange on ARF1 and ARF3, respectively, raising the
possibility that these GEFs function in the Golgi. However, the actual
function of these proteins may be determined in part by their ability
to interact with specific ARFs and in part by their subcellular
localization. We report here that in vitro ARNO can
stimulate nucleotide exchange on both ARF1 and ARF6. Furthermore, based
on subcellular fractionation and immunolocalization experiments, we
find that ARNO is localized to the plasma membrane in mammalian cells
rather than the Golgi. It is therefore likely that ARNO functions in
plasma membrane events by modulating the activity of ARF6 in
vivo. These findings are consistent with the previous observation
that cytohesin-1 regulates the adhesiveness of Combined Program in Pediatric
Gastroenterology and Nutrition, Massachusetts General Hospital East,
Charlestown, Masschusetts 02129 and the Programs in
§ Immunology and Biological and Biomedical
Sciences, Harvard Medical School, Boston, Massachusetts 02115
L
2 integrins at the plasma membrane of lymphocytes.
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S. E. Langille, V. Patki, J. K. Klarlund, J. M. Buxton, J. J. Holik, A. Chawla, S. Corvera, and M. P. Czech ADP-ribosylation Factor 6 as a Target of Guanine Nucleotide Exchange Factor GRP1 J. Biol. Chem., September 17, 1999; 274(38): 27099 - 27104. [Abstract] [Full Text] [PDF]
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C. Z. Yang and M. Mueckler ADP-ribosylation Factor 6 (ARF6) Defines Two Insulin-regulated Secretory Pathways in Adipocytes J. Biol. Chem., September 3, 1999; 274(36): 25297 - 25300. [Abstract] [Full Text] [PDF]
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 S. Jones, G. Jedd, R. A. Kahn, A. Franzusoff, F. Bartolini, and N. Segev Genetic Interactions in Yeast Between Ypt GTPases and Arf Guanine Nucleotide Exchangers Genetics, August 1, 1999; 152(4): 1543 - 1556. [Abstract] [Full Text]
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A. Claude, B.-P. Zhao, C. E. Kuziemsky, S. Dahan, S. J. Berger, J.-P. Yan, A. D. Armold, E. M. Sullivan, and P. Melancon GBF1: A Novel Golgi-associated BFA-resistant Guanine Nucleotide Exchange Factor That Displays Specificity for ADP-ribosylation Factor 5 J. Cell Biol., July 12, 1999; 146(1): 71 - 84. [Abstract] [Full Text] [PDF]
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S. J. Mansour, J. Skaug, X.-H. Zhao, J. Giordano, S. W. Scherer, and P. Melancon p200 ARF-GEP1: A Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A PNAS, July 6, 1999; 96(14): 7968 - 7973. [Abstract] [Full Text] [PDF]
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N. Morinaga, R. Adamik, J. Moss, and M. Vaughan Brefeldin A Inhibited Activity of the Sec7 Domain of p200, a Mammalian Guanine Nucleotide-exchange Protein for ADP-ribosylation Factors J. Biol. Chem., June 18, 1999; 274(25): 17417 - 17423. [Abstract] [Full Text] [PDF]
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G. Pacheco-Rodriguez, W. A. Patton, R. Adamik, H.-S. Yoo, F.-J. S. Lee, G.-F. Zhang, J. Moss, and M. Vaughan Structural Elements of ADP-ribosylation Factor 1 Required for Functional Interaction with Cytohesin-1 J. Biol. Chem., April 30, 1999; 274(18): 12438 - 12444. [Abstract] [Full Text] [PDF]
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M. Sata, J. Moss, and M. Vaughan Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors PNAS, March 16, 1999; 96(6): 2752 - 2757. [Abstract] [Full Text] [PDF]
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J. Andreev, J.-P. Simon, D. D. Sabatini, J. Kam, G. Plowman, P. A. Randazzo, and J. Schlessinger Identification of a New Pyk2 Target Protein with Arf-GAP Activity Mol. Cell. Biol., March 1, 1999; 19(3): 2338 - 2350. [Abstract] [Full Text] [PDF]
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U. Ashery, H. Koch, V. Scheuss, N. Brose, and J. Rettig A presynaptic role for the ADP ribosylation factor (ARF)-specific GDP/GTP exchange factor msec7-1 PNAS, February 2, 1999; 96(3): 1094 - 1099. [Abstract] [Full Text] [PDF]
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M. P. Czech and S. Corvera Signaling Mechanisms That Regulate Glucose Transport J. Biol. Chem., January 22, 1999; 274(4): 1865 - 1868. [Full Text] [PDF]
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D. Cox, C.-C. Tseng, G. Bjekic, and S. Greenberg A Requirement for Phosphatidylinositol 3-Kinase in Pseudopod Extension J. Biol. Chem., January 15, 1999; 274(3): 1240 - 1247. [Abstract] [Full Text] [PDF]
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K Venkateswarlu, F Gunn-Moore, J. Tavare, and P. Cullen EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain J. Cell Sci., January 6, 1999; 112(12): 1957 - 1965. [Abstract] [PDF]
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H Radhakrishna, O Al-Awar, Z Khachikian, and J. Donaldson ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements J. Cell Sci., January 3, 1999; 112(6): 855 - 866. [Abstract] [PDF]
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M. T. Brown, J. Andrade, H. Radhakrishna, J. G. Donaldson, J. A. Cooper, and P. A. Randazzo ASAP1, a Phospholipid-Dependent Arf GTPase-Activating Protein That Associates with and Is Phosphorylated by Src Mol. Cell. Biol., December 1, 1998; 18(12): 7038 - 7051. [Abstract] [Full Text]
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S. R. Frank, J. C. Hatfield, and J. E. Casanova Remodeling of the Actin Cytoskeleton Is Coordinately Regulated by Protein Kinase C and the ADP-Ribosylation Factor Nucleotide Exchange Factor ARNO Mol. Biol. Cell, November 1, 1998; 9(11): 3133 - 3146. [Abstract] [Full Text]
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G. Pacheco-Rodriguez, E. Meacci, N. Vitale, J. Moss, and M. Vaughan Guanine Nucleotide Exchange on ADP-ribosylation Factors Catalyzed by Cytohesin-1 and Its Sec7 Domain J. Biol. Chem., October 9, 1998; 273(41): 26543 - 26548. [Abstract] [Full Text] [PDF]
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J. Moss and M. Vaughan Molecules in the ARF Orbit J. Biol. Chem., August 21, 1998; 273(34): 21431 - 21434. [Full Text] [PDF]
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M. Franco, J. Boretto, S. Robineau, S. Monier, B. Goud, P. Chardin, and P. Chavrier ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function PNAS, August 18, 1998; 95(17): 9926 - 9931. [Abstract] [Full Text] [PDF]
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