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Vol. 273, Issue 1, 446-452, January 2, 1998
From the Department of Biochemistry, Dartmouth Medical School,
Hanover, New Hampshire 03755-3844
Circadian clocks function to govern a wide range
of rhythmic activities in organisms. An integral part of rhythmicity is
the daily control of target genes by the clock. Here we describe the sequence and analysis of a novel clock-controlled gene,
ccg-7, showing similarity to glyceraldehyde-3-phosphate
dehydrogenase (GAPDH), a glycolytic enzyme widely used as a
constitutive control in a variety of systems. That ccg-7
encodes GAPDH was confirmed by demonstrating that in vitro
synthesized CCG-7 possesses GAPDH activity. Rhythms in both
ccg-7 mRNA accumulation and CCG-7 (GAPDH) activity are
observed in a clock wild-type strain where the peak in GAPDH activity
lags several hours behind the peak in ccg-7 mRNA
accumulation in the late night. Together with our previous observation
that ccg-7 mRNA is not developmentally regulated, we
show that ccg-7 is not induced by environmental stresses
such as glucose or nitrogen deprivation (which also trigger
development), heat shock, or osmotic stress. Thus, the finding that
GAPDH is clock-regulated points to a specific role for the circadian
clock in controlling aspects of general metabolism and provides
evidence for circadian regulation of a gene found in most living
organisms.
Glyceraldehyde-3-phosphate Dehydrogenase Is Regulated on a Daily
Basis by the Circadian Clock
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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