JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boss, O.
Right arrow Articles by Muzzin, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boss, O.
Right arrow Articles by Muzzin, P.

Vol. 273, Issue 1, 5-8, January 2, 1998

COMMUNICATION
Uncoupling Protein-3 Expression in Rodent Skeletal Muscle Is Modulated by Food Intake but Not by Changes in Environmental Temperature

Olivier BossDagger , Sonia Samec, Françoise KühneDagger , Philippe Bijlenga, Françoise Assimacopoulos-JeannetDagger , Josiane Seydoux, Jean-Paul GiacobinoDagger , and Patrick MuzzinDagger

From the Departments of Dagger  Medical Biochemistry and  Physiology, Faculty of Medicine, University of Geneva, 1 Michel Servet, 1211 Geneva 4, Switzerland

A new member of the uncoupling protein (UCP) family called UCP3 has recently been cloned and shown to be highly expressed in skeletal muscle of rodents and humans. In the present study, UCP3 was overexpressed in C2C12 myoblasts where it acts as an uncoupling protein. Changes in UCP3 mRNA expression were examined in rodent muscles under conditions known to modulate thermogenesis in brown adipose tissue. In skeletal muscle, UCP3 expression did not change in response to 48 h of cold exposure (6 °C), whereas it was decreased by 81% or increased 5.6-fold by 1 week of 50% food restriction or fasting, respectively. It was also decreased by 36% in soleus muscle of obese (fa/fa) as compared with lean Zucker rats. The unexpected rise of UCP3 mRNA level induced by fasting did not change in vitro muscle basal heat production rate but decreased by 31% the capacity to produce heat in response to the uncoupler carbonylcyanide p-trifluoromethoxyphenylhydrazone. This decrease may reflect underlying uncoupling by UCP3. Up-regulation of UCP3 mRNA after a 24-h fast was still observed in mice exposed at thermoneutrality. These results show that the increase in UCP3 expression induced by fasting is associated with the maintenance of thermogenesis measured in muscle in vitro and is not modulated by environmental temperature. The notion that UCP3 expression is modulated by food intake is of importance to better understand the pathophysiology of obesity in humans.


Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.



This article has been cited by other articles:


Home page
FASEB J.Home page
S. Summermatter, D. Mainieri, A. P. Russell, J. Seydoux, J. P. Montani, A. Buchala, G. Solinas, and A. G. Dulloo
Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle phosphatidylinositol-3-kinase activity and AMP-activated protein kinase
FASEB J, March 1, 2008; 22(3): 774 - 785.
[Abstract] [Full Text] [PDF]


Home page
J ANIM SCIHome page
E. L. Sherman, J. D. Nkrumah, B. M. Murdoch, C. Li, Z. Wang, A. Fu, and S. S. Moore
Polymorphisms and haplotypes in the bovine neuropeptide Y, growth hormone receptor, ghrelin, insulin-like growth factor 2, and uncoupling proteins 2 and 3 genes and their associations with measures of growth, performance, feed efficiency, and carcass merit in beef cattle
J Anim Sci, January 1, 2008; 86(1): 1 - 16.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
E. J. Anderson, H. Yamazaki, and P. D. Neufer
Induction of Endogenous Uncoupling Protein 3 Suppresses Mitochondrial Oxidant Emission during Fatty Acid-supported Respiration
J. Biol. Chem., October 26, 2007; 282(43): 31257 - 31266.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
R. C. Noland, J. P. Thyfault, S. T. Henes, B. R. Whitfield, T. L. Woodlief, J. R. Evans, J. A. Lust, S. L. Britton, L. G. Koch, R. W. Dudek, et al.
Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance
Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E31 - E41.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
V. Bezaire, E. L. Seifert, and M.-E. Harper
Uncoupling protein-3: clues in an ongoing mitochondrial mystery
FASEB J, February 1, 2007; 21(2): 312 - 324.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
J. E. Sprague, X. Yang, J. Sommers, T. L. Gilman, and E. M. Mills
Roles of Norepinephrine, Free Fatty Acids, Thyroid Status, and Skeletal Muscle Uncoupling Protein 3 Expression in Sympathomimetic-Induced Thermogenesis
J. Pharmacol. Exp. Ther., January 1, 2007; 320(1): 274 - 280.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
D. Mainieri, S. Summermatter, J. Seydoux, J.-P. Montani, S. Rusconi, A. P. Russell, O. Boss, A. J. Buchala, and A. G. Dulloo
A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis
FASEB J, August 1, 2006; 20(10): 1751 - 1753.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
F. X. Soriano, M. Liesa, D. Bach, D. C. Chan, M. Palacin, and A. Zorzano
Evidence for a Mitochondrial Regulatory Pathway Defined by Peroxisome Proliferator-Activated Receptor-{gamma} Coactivator-1{alpha}, Estrogen-Related Receptor-{alpha}, and Mitofusin 2
Diabetes, June 1, 2006; 55(6): 1783 - 1791.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
H. Chen, M. J. Hansen, J. E. Jones, R. Vlahos, S. Bozinovski, G. P. Anderson, and M. J. Morris
Cigarette Smoke Exposure Reprograms the Hypothalamic Neuropeptide Y Axis to Promote Weight Loss
Am. J. Respir. Crit. Care Med., June 1, 2006; 173(11): 1248 - 1254.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
S. R. Costford, S. N. Chaudhry, M. Salkhordeh, and M.-E. Harper
Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice
Am J Physiol Endocrinol Metab, June 1, 2006; 290(6): E1304 - E1312.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Biol.Home page
P. J. Schaeffer, J. J. Villarin, D. J. Pierotti, D. P. Kelly, and S. L. Lindstedt
Cost of transport is increased after cold exposure in Monodelphis domestica: training for inefficiency
J. Exp. Biol., August 15, 2005; 208(16): 3159 - 3167.
[Abstract] [Full Text] [PDF]


Home page
Physiol. GenomicsHome page
P. A. Keller, L. Lehr, J.-P. Giacobino, Y. Charnay, F. Assimacopoulos-Jeannet, and N. Giovannini
Cloning, ontogenesis, and localization of an atypical uncoupling protein 4 in Xenopus laevis
Physiol Genomics, August 11, 2005; 22(3): 339 - 345.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
A. Valle, A. Catala-Niell, B. Colom, F. J. Garcia-Palmer, J. Oliver, and P. Roca
Sex-related differences in energy balance in response to caloric restriction
Am J Physiol Endocrinol Metab, July 1, 2005; 289(1): E15 - E22.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. R. Commerford, L. Peng, J. J. Dube, and R. M. O'Doherty
In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R218 - R227.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
B. CANNON and J. NEDERGAARD
Brown Adipose Tissue: Function and Physiological Significance
Physiol Rev, January 1, 2004; 84(1): 277 - 359.
[Abstract] [Full Text] [PDF]


Home page
Mol. Endocrinol.Home page
U. Dressel, T. L. Allen, J. B. Pippal, P. R. Rohde, P. Lau, and G. E. O. Muscat
The Peroxisome Proliferator-Activated Receptor {beta}/{delta} Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells
Mol. Endocrinol., December 1, 2003; 17(12): 2477 - 2493.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
J. G. Peralta, P. V. Finocchietto, D. Converso, F. Schopfer, M. C. Carreras, and J. J. Poderoso
Modulation of mitochondrial nitric oxide synthase and energy expenditure in rats during cold acclimation
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2375 - H2383.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
A. Collin, M. Taouis, J. Buyse, N. B. Ifuta, V. M. Darras, P. Van As, R. D. Malheiros, V. M. B. Moraes, and E. Decuypere
Thyroid status, but not insulin status, affects expression of avian uncoupling protein mRNA in chicken
Am J Physiol Endocrinol Metab, April 1, 2003; 284(4): E771 - E777.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
H. Pilegaard, B. Saltin, and P. D. Neufer
Effect of Short-Term Fasting and Refeeding on Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle
Diabetes, March 1, 2003; 52(3): 657 - 662.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
T. Teruel, R. Hernandez, M. Benito, and M. Lorenzo
Rosiglitazone and Retinoic Acid Induce Uncoupling Protein-1 (UCP-1) in a p38 Mitogen-activated Protein Kinase-dependent Manner in Fetal Primary Brown Adipocytes
J. Biol. Chem., January 3, 2003; 278(1): 263 - 269.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
M.-E. Harper, R. Dent, S. Monemdjou, V. Bezaire, L. Van Wyck, G. Wells, G. N. Kavaslar, A. Gauthier, F. Tesson, and R. McPherson
Decreased Mitochondrial Proton Leak and Reduced Expression of Uncoupling Protein 3 in Skeletal Muscle of Obese Diet-Resistant Women
Diabetes, August 1, 2002; 51(8): 2459 - 2466.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Biol.Home page
P. Schrauwen and M. Hesselink
UCP2 and UCP3 in muscle controlling body metabolism
J. Exp. Biol., August 1, 2002; 205(15): 2275 - 2285.
[Abstract] [Full Text] [PDF]


Home page
Ann. N. Y. Acad. Sci.Home page
J.-P. GIACOBINO
Uncoupling Proteins, Leptin, and Obesity: An Updated Review
Ann. N.Y. Acad. Sci., June 1, 2002; 967(1): 398 - 402.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
I. Guillet-Deniau, V. Mieulet, S. Le Lay, Y. Achouri, D. Carre, J. Girard, F. Foufelle, and P. Ferre
Sterol Regulatory Element Binding Protein-1c Expression and Action in Rat Muscles: Insulin-Like Effects on the Control of Glycolytic and Lipogenic Enzymes and UCP3 Gene Expression
Diabetes, June 1, 2002; 51(6): 1722 - 1728.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
G. Argyropoulos and M.-E. Harper
Molecular Biology of Thermoregulation: Invited Review: Uncoupling proteins and thermoregulation
J Appl Physiol, May 1, 2002; 92(5): 2187 - 2198.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
V. M Rodriguez, M. P Portillo, C. Pico, M T. Macarulla, and A. Palou
Olive oil feeding up-regulates uncoupling protein genes in rat brown adipose tissue and skeletal muscle
Am. J. Clinical Nutrition, February 1, 2002; 75(2): 213 - 220.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. M. Kotz, C. Wang, A. S. Levine, and C. J. Billington
Urocortin in the hypothalamic PVN increases leptin and affects uncoupling proteins-1 and -3 in rats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R546 - R551.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
P. SCHRAUWEN, W. H. M. SARIS, and M. K. C. HESSELINK
An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix
FASEB J, November 1, 2001; 15(13): 2497 - 2502.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
V. Bezaire, W. Hofmann, J. K. G. Kramer, L. P. Kozak, and M.-E. Harper
Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice
Am J Physiol Endocrinol Metab, November 1, 2001; 281(5): E975 - E982.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
P. de Lange, A. Lanni, L. Beneduce, M. Moreno, A. Lombardi, E. Silvestri, and F. Goglia
Uncoupling Protein-3 Is a Molecular Determinant for the Regulation of Resting Metabolic Rate by Thyroid Hormone
Endocrinology, August 1, 2001; 142(8): 3414 - 3420.
[Abstract] [Full Text] [PDF]


Home page
Physiol. GenomicsHome page
C. R. VIANNA, T. HAGEN, C.-Y. ZHANG, E. BACHMAN, O. BOSS, B. GEREBEN, A. S. MORISCOT, B. B. LOWELL, J. E. P. W. BICUDO, and A. C. BIANCO
Cloning and functional characterization of an uncoupling protein homolog in hummingbirds
Physiol Genomics, April 2, 2001; 5(3): 137 - 145.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
R. Weindruch, K. P. Keenan, J. M. Carney, G. Fernandes, R. J. Feuers, R. A. Floyd, J. B. Halter, J. J. Ramsey, A. Richardson, G. S. Roth, et al.
Caloric Restriction Mimetics: Metabolic Interventions
J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2001; 56(90001): 20 - 33.
[Abstract] [Full Text] [PDF]


Home page
Exp. Biol. Med.Home page
J. Himms-Hagen and M.-E. Harper
Physiological Role of UCP3 May Be Export of Fatty Acids from Mitochondria When Fatty Acid Oxidation Predominates: An Hypothesis
Experimental Biology and Medicine, February 1, 2001; 226(2): 78 - 84.
[Abstract] [Full Text]


Home page
EndocrinologyHome page
Y. Hong, B. D. Fink, J. S. Dillon, and W. I. Sivitz
Effects of Adenoviral Overexpression of Uncoupling Protein-2 and -3 on Mitochondrial Respiration in Insulinoma Cells
Endocrinology, January 1, 2001; 142(1): 249 - 256.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
S. Monemdjou, W. E. Hofmann, L. P. Kozak, and M.-E. Harper
Increased mitochondrial proton leak in skeletal muscle mitochondria of UCP1-deficient mice
Am J Physiol Endocrinol Metab, October 1, 2000; 279(4): E941 - E946.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
M. Zhou, B.-Z. Lin, S. Coughlin, G. Vallega, and P. F. Pilch
UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase
Am J Physiol Endocrinol Metab, September 1, 2000; 279(3): E622 - E629.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
X. X. YU, W. MAO, A. ZHONG, P. SCHOW, J. BRUSH, S. W. SHERWOOD, S. H. ADAMS, and G. PAN
Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation
FASEB J, August 1, 2000; 14(11): 1611 - 1618.
[Abstract] [Full Text]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
X. X. Yu, J. L. Barger, B. B. Boyer, M. D. Brand, G. Pan, and S. H. Adams
Impact of endotoxin on UCP homolog mRNA abundance, thermoregulation, and mitochondrial proton leak kinetics
Am J Physiol Endocrinol Metab, August 1, 2000; 279(2): E433 - E446.
[Abstract] [Full Text] [PDF]


Home page
Exp. Biol. Med.Home page
S. Hidaka, H. Yoshimatsu, T. Kakuma, H. Sakino, S. Kondou, R. Hanada, K. Oka, Y. Teshima, M. Kurokawa, and T. Sakata
Tissue-Specific Expression of the Uncoupling Protein Family in Streptozotocin-Induced Diabetic Rats
Experimental Biology and Medicine, July 1, 2000; 224(3): 172 - 177.
[Abstract] [Full Text]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
A. L. Hildebrandt and P. D. Neufer
Exercise attenuates the fasting-induced transcriptional activation of metabolic genes in skeletal muscle
Am J Physiol Endocrinol Metab, June 1, 2000; 278(6): E1078 - E1086.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. Bing, M. Brown, P. King, P. Collins, M. J. Tisdale, and G. Williams
Increased Gene Expression of Brown Fat Uncoupling Protein (UCP)1 and Skeletal Muscle UCP2 and UCP3 in MAC16-induced Cancer Cachexia
Cancer Res., May 1, 2000; 60(9): 2405 - 2410.
[Abstract] [Full Text]


Home page
J. Nutr.Home page
S. H. Adams
Uncoupling Protein Homologs: Emerging Views of Physiological Function
J. Nutr., April 1, 2000; 130(4): 711 - 714.
[Abstract] [Full Text]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. M. Kotz, C. F. Wang, J. E. Briggs, A. S. Levine, and C. J. Billington
Effect of NPY in the hypothalamic paraventricular nucleus on uncoupling proteins 1, 2, and 3 in the rat
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R494 - R498.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
S. B. Pedersen, K. Kristensen, S. Fisker, J. O. L. Jørgensen, J. S. Christiansen, and B. Richelsen
Regulation of Uncoupling Protein-2 and -3 by Growth Hormone in Skeletal Muscle and Adipose Tissue in Growth Hormone-Deficient Adults
J. Clin. Endocrinol. Metab., November 1, 1999; 84(11): 4073 - 4078.
[Abstract] [Full Text]


Home page
Endocr. Rev.Home page
B. Desvergne and W. Wahli
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism
Endocr. Rev., October 1, 1999; 20(5): 649 - 688.
[Abstract] [Full Text]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
W. I. Sivitz, B. D. Fink, D. A. Morgan, J. M. Fox, P. A. Donohoue, and W. G. Haynes
Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats
Am J Physiol Endocrinol Metab, October 1, 1999; 277(4): E668 - E677.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
M. B. Jekabsons, F. M. Gregoire, N. A. Schonfeld-Warden, C. H. Warden, and B. A. Horwitz
T3 stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not nonphosphorylating mitochondrial respiration in mice
Am J Physiol Endocrinol Metab, August 1, 1999; 277(2): E380 - E389.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
W. I. Sivitz, B. D. Fink, and P. A. Donohoue
Fasting and Leptin Modulate Adipose and Muscle Uncoupling Protein: Divergent Effects Between Messenger Ribonucleic Acid and Protein Expression
Endocrinology, April 1, 1999; 140(4): 1511 - 1519.
[Abstract] [Full Text]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
R. N. Cortright, D. Zheng, J. P. Jones, J. D. Fluckey, S. E. DiCarlo, D. Grujic, B. B. Lowell, and G. L. Dohm
Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation
Am J Physiol Endocrinol Metab, January 1, 1999; 276(1): E217 - E221.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
L. J. Kelly, P. P. Vicario, G. M. Thompson, M. R. Candelore, T. W. Doebber, J. Ventre, M. S. Wu, R. Meurer, M. J. Forrest, M. W. Conner, et al.
Peroxisome Proliferator-Activated Receptors {gamma} and {alpha} Mediate in Vivo Regulation of Uncoupling Protein (UCP-1, UCP-2, UCP-3) Gene Expression
Endocrinology, December 1, 1998; 139(12): 4920 - 4927.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. B. Boyer, B. M. Barnes, B. B. Lowell, and D. Grujic
Differential regulation of uncoupling protein gene homologues in multiple tissues of hibernating ground squirrels
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1232 - R1238.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
B. Lin, S. Coughlin, and P. F. Pilch
Bidirectional regulation of uncoupling protein-3 and GLUT-4 mRNA in skeletal muscle by cold
Am J Physiol Endocrinol Metab, September 1, 1998; 275(3): E386 - E391.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
P. Barbe, L. Millet, D. Larrouy, J. Galitzky, M. Berlan, J.-P. Louvet, and D. Langin
Uncoupling Protein-2 Messenger Ribonucleic Acid Expression During Very-Low-Calorie Diet in Obese Premenopausal Women
J. Clin. Endocrinol. Metab., July 1, 1998; 83(7): 2450 - 2453.
[Abstract] [Full Text]


Home page
J. Biol. Chem.Home page
A. Matthias, K. B. E. Ohlson, J. M. Fredriksson, A. Jacobsson, J. Nedergaard, and B. Cannon
Thermogenic Responses in Brown Fat Cells Are Fully UCP1-dependent. UCP2 OR UCP3 DO NOT SUBSTITUTE FOR UCP1 IN ADRENERGICALLY OR FATTY ACID-INDUCED THERMOGENESIS
J. Biol. Chem., August 11, 2000; 275(33): 25073 - 25081.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
B. M. Jucker, J. Ren, S. Dufour, X. Cao, S. F. Previs, K. S. Cadman, and G. I. Shulman
13C/31P NMR Assessment of Mitochondrial Energy Coupling in Skeletal Muscle of Awake Fed and Fasted Rats. RELATIONSHIP WITH UNCOUPLING PROTEIN 3 EXPRESSION
J. Biol. Chem., December 8, 2000; 275(50): 39279 - 39286.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
C. Huppertz, B. M. Fischer, Y.-B. Kim, K. Kotani, A. Vidal-Puig, L. J. Slieker, K. W. Sloop, B. B. Lowell, and B. B. Kahn
Uncoupling Protein 3 (UCP3) Stimulates Glucose Uptake in Muscle Cells through a Phosphoinositide 3-Kinase-dependent Mechanism
J. Biol. Chem., April 13, 2001; 276(16): 12520 - 12529.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
L. de Meis
Uncoupled ATPase Activity and Heat Production by the Sarcoplasmic Reticulum Ca2+-ATPase. REGULATION BY ADP
J. Biol. Chem., June 29, 2001; 276(27): 25078 - 25087.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
S. Cadenas, K. S. Echtay, J. A. Harper, M. B. Jekabsons, J. A. Buckingham, E. Grau, A. Abuin, H. Chapman, J. C. Clapham, and M. D. Brand
The Basal Proton Conductance of Skeletal Muscle Mitochondria from Transgenic Mice Overexpressing or Lacking Uncoupling Protein-3
J. Biol. Chem., January 18, 2002; 277(4): 2773 - 2778.
[Abstract] [Full Text] [PDF]


Home page