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Vol. 273, Issue 1, 58-65, January 2, 1998
-N-Acetylglucosamine
1,3-Galactosyltransferase Genes
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From the Based on the detection of expressed sequence tags
that are similar to known galactosyltransferase sequences, we have
isolated three novel
UDP-galactose: Institute of Physiology, University of
Zurich, 8057 Zurich, Switzerland, the ¶ Institute of Veterinary
Bacteriology, University of Berne, 3012 Berne, Switzerland, and the
Glycobiology Institute, Department of Biochemistry, Oxford
University, Oxford OX1 3QU, United Kingdom
-N-acetylglucosamine
1,3-galactosyltransferase (3GalT) genes from a mouse
genomic library. The three genes, named 3GalT-I, -II, and -III,
encode type II transmembrane proteins of 326, 422, and 331 amino acids,
respectively. The three proteins constitute a distinct subfamily as
they do not share any sequence identity with other eucaryotic
galactosyltransferases. Also, the entire protein-coding region of the
three 3GalT genes was contained in a single exon, which contrasts
with the genomic organization of the 1,4- and
1,3-galactosyltransferase genes. The three 3GalT genes were
mainly expressed in brain tissue. The expression of the full-length
murine genes as recombinant baculoviruses in insect cells revealed that
the 3GalT enzymes share the same acceptor specificity for -linked
GlcNAc, although they differ in their Km for this
acceptor and the donor UDP-Gal. The identification of 3GalT genes
emphasizes the structural diversity present in the
galactosyltransferase gene family.
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