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Vol. 273, Issue 1, 627-635, January 2, 1998
From the Forschungszentrum Karlsruhe, The homeobox gene goosecoid has been
implicated to play a central role in the Spemann organizer tissue of
the vertebrate embryo. Misexpression of goosecoid on the
ventral side of a Xenopus laevis gastrula embryo was shown
to result in a partial duplication of the primary body axis,
reminiscent of the Spemann organizer graft. Normal embryonic
development thus requires tight temporal and spatial control of genes
instrumental for organizer function. In the present study we
investigated the transcriptional control of goosecoid gene
expression. Sequence analysis of the mouse and human promoter region
revealed the presence of two palindromic binding elements for homeobox
genes of the prd type to which goosecoid belongs. We show that Goosecoid protein can bind to these sites in vitro. By using reporter gene constructs of the human
and mouse promoter, we demonstrate that Goosecoid can act as a
repressor of its own promoter activity in transient co-transfection
experiments in mouse P19 cells and in Xenopus embryos.
Autorepression depends on the presence of the homeodomain and is
mediated through the prd element more proximal to the
transcriptional start site. Our results suggest a role for
goosecoid in restricting organizer activity in the
vertebrate gastrula embryo.
Negative Autoregulation of the Organizer-specific Homeobox
Gene goosecoid
Department of Cell
Biology,
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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