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J Biol Chem, Vol. 273, Issue 10, 5423-5426, March 6, 1998
,
, and
From the Departments of Activation of stress-activated
protein kinases, including the p38 and the c-Jun
NH2-terminal kinases (JNK), have been associated with the
onset of cardiac hypertrophy and cell death in response to hemodynamic
overload and ischemia/reperfusion injury. Upon infection of cultured
neonatal rat cardiac myocytes with recombinant adenoviral vectors
expressing a wild type and a constitutively active mutant of MKK7 (or
JNKK2), JNK was specifically activated without affecting other
mitogen-activated protein kinases, including extracellular
signal-regulated protein kinases and p38. Specific activation of the
JNK pathway in cardiac myocytes induced characteristic features of
hypertrophy, including an increase in cell size, elevated expression of
atrial natriuretic factor, and induction of sarcomere organization. In
contrast, co-activation of both JNK (by MKK7) and p38 (by MKK3 or MKK6)
in cardiomyocytes led to an induction of cytopathic responses and
suppression of hypertrophic responses. These data provide the first
direct evidence that activation of JNK alone is sufficient to induce
characteristic features of cardiac hypertrophy, thereby supporting an
active role for the JNK pathway in the development of cardiac
hypertrophy. The cytopathic response, as a result of co-activation of
both JNK and p38, may contribute to the loss of contractile function
and viability of cardiomyocytes following hemodynamic overload and
cardiac ischemia/reperfusion injury.
Medicine and
¶ Pharmacology, University of California at San Diego, La Jolla,
California 92093, the § Department of Immunology, University
of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, and the
Department of Immunology, The Scripps Research Institute,
La Jolla, California 92037
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|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
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|
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|
|
 |
|
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|
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