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J Biol Chem, Vol. 273, Issue 11, 6525-6532, March 13, 1998
From the Caveolin is a 22-kDa protein that appears to play
a critical role in regulating the cholesterol concentration of
caveolae. Even though caveolin is thought to be a membrane protein,
several reports suggest that this peculiar protein can traffic
independently of membrane vesicles. We now present evidence that a
cytosolic pool of caveolin is part of a heat-shock protein-immunophilin chaperone complex consisting of caveolin, heat-shock protein 56, cyclophilin 40, cyclophilin A, and cholesterol. Treatment of NIH 3T3
cells with 1 µM cyclosporin A or 100 nM
rapamycin disrupted the putative transport complex and prevented rapid
(10-20 min) transport of cholesterol to caveolae. The lymphoid cell
line, L1210-JF, does not express caveolin, does not form an
immunophilin-caveolin complex, and does not transport newly synthesized
cholesterol to caveolae. Transfection of caveolin cDNA into
L1210-JF cells allowed the assembly of a transport complex identical to
that found in NIH 3T3 cells. In addition, newly synthesized cholesterol in transfected cells was rapidly (10-20 min) and specifically transported to caveolae. These data strongly suggest that a
caveolin-chaperone complex is a mechanism by which newly synthesized
cholesterol is transported from the endoplasmic reticulum through the
cytoplasm to caveolae.
Characterization of a Cytosolic Heat-shock Protein-Caveolin
Chaperone Complex
INVOLVEMENT IN CHOLESTEROL TRAFFICKING
,
University of Kentucky Medical School,
Department of Physiology, MS 508, Lexington, Kentucky 40536 and the
§ University of Texas Southwestern Medical Center,
Department of Cell Biology and Neuroscience, Dallas, Texas 75235
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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A. Uittenbogaard, P. W. Shaul, I. S. Yuhanna, A. Blair, and E. J. Smart High Density Lipoprotein Prevents Oxidized Low Density Lipoprotein-induced Inhibition of Endothelial Nitric-oxide Synthase Localization and Activation in Caveolae J. Biol. Chem., April 6, 2000; 275(15): 11278 - 11283. [Abstract] [Full Text] [PDF]
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S Prattes, G Horl, A Hammer, A Blaschitz, W. Graier, W Sattler, R Zechner, and E Steyrer Intracellular distribution and mobilization of unesterified cholesterol in adipocytes: triglyceride droplets are surrounded by cholesterol-rich ER-like surface layer structures J. Cell Sci., January 9, 2000; 113(17): 2977 - 2989. [Abstract] [PDF]
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G. Bathori, I. Parolini, F. Tombola, I. Szabo, A. Messina, M. Oliva, V. De Pinto, M. Lisanti, M. Sargiacomo, and M. Zoratti Porin Is Present in the Plasma Membrane Where It Is Concentrated in Caveolae and Caveolae-related Domains J. Biol. Chem., October 15, 1999; 274(42): 29607 - 29612. [Abstract] [Full Text] [PDF]
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S. Matveev, D. R. van der Westhuyzen, and E. J. Smart Co-expression of scavenger receptor-BI and caveolin-1 is associated with enhanced selective cholesteryl ester uptake in THP-1 macrophages J. Lipid Res., September 1, 1999; 40(9): 1647 - 1654. [Abstract] [Full Text]
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S. Oliferenko, K. Paiha, T. Harder, V. Gerke, C. Schwarzler, H. Schwarz, H. Beug, U. Gunthert, and L. A. Huber Analysis of CD44-containing Lipid Rafts: Recruitment of Annexin II and Stabilization by the Actin Cytoskeleton J. Cell Biol., August 23, 1999; 146(4): 843 - 854. [Abstract] [Full Text] [PDF]
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G. Sowa, J. Liu, A. Papapetropoulos, M. Rex-Haffner, T. E. Hughes, and W. C. Sessa Trafficking of Endothelial Nitric-oxide Synthase in Living Cells. QUANTITATIVE EVIDENCE SUPPORTING THE ROLE OF PALMITOYLATION AS A KINETIC TRAPPING MECHANISM LIMITING MEMBRANE DIFFUSION J. Biol. Chem., August 6, 1999; 274(32): 22524 - 22531. [Abstract] [Full Text] [PDF]
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R. Luetterforst, E. Stang, N. Zorzi, A. Carozzi, M. Way, and R. G. Parton Molecular Characterization of Caveolin Association with the Golgi Complex: Identification of a Cis-Golgi Targeting Domain in the Caveolin Molecule J. Cell Biol., June 28, 1999; 145(7): 1443 - 1459. [Abstract] [Full Text] [PDF]
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G. A. Graf, P. M. Connell, D. R. van der Westhuyzen, and E. J. Smart The Class B, Type I Scavenger Receptor Promotes the Selective Uptake of High Density Lipoprotein Cholesterol Ethers into Caveolae J. Biol. Chem., April 23, 1999; 274(17): 12043 - 12048. [Abstract] [Full Text] [PDF]
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Y. Lavie, G. Fiucci, and M. Liscovitch Up-regulation of Caveolae and Caveolar Constituents in Multidrug-resistant Cancer Cells J. Biol. Chem., December 4, 1998; 273(49): 32380 - 32383. [Abstract] [Full Text] [PDF]
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 P. W. Shaul and R. G. W. Anderson Role of plasmalemmal caveolae in signal transduction Am J Physiol Lung Cell Mol Physiol, November 1, 1998; 275(5): L843 - L851. [Abstract] [Full Text] [PDF]
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A. H. Tinkelenberg, Y. Liu, F. Alcantara, S. Khan, Z. Guo, M. Bard, and S. L. Sturley Mutations in Yeast ARV1 Alter Intracellular Sterol Distribution and Are Complemented by Human ARV1 J. Biol. Chem., December 22, 2000; 275(52): 40667 - 40670. [Abstract] [Full Text] [PDF]
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J.-P. Gratton, J. Fontana, D. S. O'Connor, G. Garcia-Cardena, T. J. McCabe, and W. C. Sessa Reconstitution of an Endothelial Nitric-oxide Synthase (eNOS), hsp90, and Caveolin-1 Complex in Vitro. EVIDENCE THAT hsp90 FACILITATES CALMODULIN STIMULATED DISPLACEMENT OF eNOS FROM CAVEOLIN-1 J. Biol. Chem., July 14, 2000; 275(29): 22268 - 22272. [Abstract] [Full Text] [PDF]
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A. Schlegel and M. P. Lisanti A Molecular Dissection of Caveolin-1 Membrane Attachment and Oligomerization. TWO SEPARATE REGIONS OF THE CAVEOLIN-1 C-TERMINAL DOMAIN MEDIATE MEMBRANE BINDING AND OLIGOMER/OLIGOMER INTERACTIONS IN VIVO J. Biol. Chem., July 7, 2000; 275(28): 21605 - 21617. [Abstract] [Full Text] [PDF]
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A. Uittenbogaard and E. J. Smart Palmitoylation of Caveolin-1 Is Required for Cholesterol Binding, Chaperone Complex Formation, and Rapid Transport of Cholesterol to Caveolae J. Biol. Chem., August 11, 2000; 275(33): 25595 - 25599. [Abstract] [Full Text] [PDF]
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A. Schlegel, P. Arvan, and M. P. Lisanti Caveolin-1 Binding to Endoplasmic Reticulum Membranes and Entry into the Regulated Secretory Pathway Are Regulated by Serine Phosphorylation. PROTEIN SORTING AT THE LEVEL OF THE ENDOPLASMIC RETICULUM J. Biol. Chem., February 2, 2001; 276(6): 4398 - 4408. [Abstract] [Full Text] [PDF]
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M. L. Lu, M. C. Schneider, Y. Zheng, X. Zhang, and J. P. Richie Caveolin-1 Interacts with Androgen Receptor. A POSITIVE MODULATOR OF ANDROGEN RECEPTOR MEDIATED TRANSACTIVATION J. Biol. Chem., April 13, 2001; 276(16): 13442 - 13451. [Abstract] [Full Text] [PDF]
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M.-O. Parat and P. L. Fox Palmitoylation of Caveolin-1 in Endothelial Cells Is Post-translational but Irreversible J. Biol. Chem., May 4, 2001; 276(19): 15776 - 15782. [Abstract] [Full Text] [PDF]
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J. C. Cruz and T.-Y. Chang Fate of Endogenously Synthesized Cholesterol in Niemann-Pick Type C1 Cells J. Biol. Chem., December 22, 2000; 275(52): 41309 - 41316. [Abstract] [Full Text] [PDF]
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H. E. Karpen, J. T. Bukowski, T. Hughes, J.-P. Gratton, W. C. Sessa, and M. R. Gailani The Sonic Hedgehog Receptor Patched Associates with Caveolin-1 in Cholesterol-rich Microdomains of the Plasma Membrane J. Biol. Chem., June 1, 2001; 276(22): 19503 - 19511. [Abstract] [Full Text] [PDF]
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P. Gargalovic and L. Dory Caveolin-1 and Caveolin-2 Expression in Mouse Macrophages. HIGH DENSITY LIPOPROTEIN 3-STIMULATED SECRETION AND A LACK OF SIGNIFICANT SUBCELLULAR CO-LOCALIZATION J. Biol. Chem., July 6, 2001; 276(28): 26164 - 26170. [Abstract] [Full Text] [PDF]
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S. Heino, S. Lusa, P. Somerharju, C. Ehnholm, V. M. Olkkonen, and E. Ikonen Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface PNAS, July 18, 2000; 97(15): 8375 - 8380. [Abstract] [Full Text] [PDF]
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S. V. Matveev and E. J. Smart Heterologous desensitization of EGF receptors and PDGF receptors by sequestration in caveolae Am J Physiol Cell Physiol, April 1, 2002; 282(4): C935 - C946. [Abstract] [Full Text] [PDF]
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