| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 273, Issue 12, 6607-6610, March 20, 1998
B
Degradation and Nuclear Factor-B DNA Binding Are
Insufficient for Interleukin-1
and Tumor Necrosis
Factor--induced B-dependent Transcription
From the Department of Thoracic Medicine, National Heart and
Lung Institute, Imperial College School of Medicine, Dovehouse
Street, London SW3 6LY, United Kingdom
Two closely related I
B
kinases as well as
the upstream kinase, NIK, which integrates interleukin-1
(IL-1)-
and tumor necrosis factor (TNF)--dependent activation of
the transcription factor NF-B have recently been described. However,
in this emerging pathway the role of previously identified components
of cytokine-induced NF-B activation, namely
phosphatidylcholine-specific phospholipase C and protein kinase C,
remains unclear. We now show that, in A549 human alveolar epithelial
cells, the activation of a stably transfected
NF-B-dependent reporter gene by TNF- and IL-1 is completely blocked by the phosphatidylcholine-specific phospholipase C
inhibitor D609 and the protein kinase C inhibitor RO31-8220. However,
IL-1-induced IB degradation as well as NF-B nuclear translocation and DNA binding, as determined by Western blot and electro-mobility shift assay, respectively, are not affected by these
inhibitors. A similar effect, although less pronounced, is observed
with the p38 mitogen-activated protein kinase inhibitor SB 203580. On
the basis of these data we propose the existence of a second signaling
pathway induced by IL-1 and TNF- that is activated in parallel to
the cascade leading to IB degradation and is specifically
required for NF-B-dependent transcriptional competency.
This article has been cited by other articles:
|
|
 |
|
  C. S. Mullan, M. Riley, D. Clarke, A. Tatler, A. Sutcliffe, A. J. Knox, and L. Pang {beta}-Tryptase Regulates IL-8 Expression in Airway Smooth Muscle Cells by a PAR-2-Independent Mechanism Am. J. Respir. Cell Mol. Biol., May 1, 2008; 38(5): 600 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Slevogt, L. Maqami, K. Vardarowa, W. Beermann, A. C. Hocke, J. Eitel, B. Schmeck, A. Weimann, B. Opitz, S. Hippenstiel, et al. Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms Eur. Respir. J., April 1, 2008; 31(4): 725 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hinz, M. Broemer, S. C. Arslan, A. Otto, E.-C. Mueller, R. Dettmer, and C. Scheidereit Signal Responsiveness of I{kappa}B Kinases Is Determined by Cdc37-assisted Transient Interaction with Hsp90 J. Biol. Chem., November 2, 2007; 282(44): 32311 - 32319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Natarajan, C F Gibbons, S Mohan, S Moore, and M A Kadhim Oxidative stress signalling: a potential mediator of tumour necrosis factor {alpha}-induced genomic instability in primary vascular endothelial cells Br. J. Radiol., September 1, 2007; 80(Special_Issue_1): S13 - S22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Tang, D.-Y. Lu, R.-S. Yang, H.-Y. Tsai, M.-C. Kao, W.-M. Fu, and Y.-F. Chen Leptin-Induced IL-6 Production Is Mediated by Leptin Receptor, Insulin Receptor Substrate-1, Phosphatidylinositol 3-Kinase, Akt, NF-{kappa}B, and p300 Pathway in Microglia J. Immunol., July 15, 2007; 179(2): 1292 - 1302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Newton, N. S. Holden, M. C. Catley, W. Oyelusi, R. Leigh, D. Proud, and P. J. Barnes Repression of Inflammatory Gene Expression in Human Pulmonary Epithelial Cells by Small-Molecule I{kappa}B Kinase Inhibitors J. Pharmacol. Exp. Ther., May 1, 2007; 321(2): 734 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-C. Chen, C.-C. Liao, M.-J. Hsu, Y.-T. Liao, C.-C. Lin, J.-R. Sheu, and C.-H. Lin Peptidoglycan-Induced IL-6 Production in RAW 264.7 Macrophages Is Mediated by Cyclooxygenase-2, PGE2/PGE4 Receptors, Protein Kinase A, I{kappa}B Kinase, and NF-{kappa}B J. Immunol., July 1, 2006; 177(1): 681 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Jundt, N. Raetzel, C. Muller, C. F. Calkhoven, K. Kley, S. Mathas, A. Lietz, A. Leutz, and B. Dorken A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein {beta} and NF-{kappa}B activity in Hodgkin and anaplastic large cell lymphomas Blood, September 1, 2005; 106(5): 1801 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Massa, X. Li, A. Hanidu, J. Siamas, M. Pariali, J. Pareja, A. G. Savitt, K. M. Catron, J. Li, and K. B. Marcu Gene Expression Profiling in Conjunction with Physiological Rescues of IKK{alpha}-null Cells with Wild Type or Mutant IKK{alpha} Reveals Distinct Classes of IKK{alpha}/NF-{kappa}B-dependent Genes J. Biol. Chem., April 8, 2005; 280(14): 14057 - 14069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. V. Ramana, B. Friedrich, R. Tammali, M. B. West, A. Bhatnagar, and S. K. Srivastava Requirement of Aldose Reductase for the Hyperglycemic Activation of Protein Kinase C and Formation of Diacylglycerol in Vascular Smooth Muscle Cells Diabetes, March 1, 2005; 54(3): 818 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Cataldegirmen, S. Zeng, N. Feirt, N. Ippagunta, H. Dun, W. Qu, Y. Lu, L. L. Rong, M. A. Hofmann, T. Kislinger, et al. RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-{alpha} and NF-{kappa}B J. Exp. Med., February 7, 2005; 201(3): 473 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kitagawa, Y. Hamada, Y. Kato, K. Nakai, M. Nishizawa, S. Ito, and T. Okumura Epidermal growth factor and interleukin-1{beta} synergistically stimulate the production of nitric oxide in rat intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, December 1, 2004; 287(6): G1188 - G1193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Donnelly, R. Newton, G. E. Kennedy, P. S. Fenwick, R. H. F. Leung, K. Ito, R. E. K. Russell, and P. J. Barnes Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms Am J Physiol Lung Cell Mol Physiol, October 1, 2004; 287(4): L774 - L783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Equils, Z. Madak, C. Liu, K. S. Michelsen, Y. Bulut, and D. Lu Rac1 and Toll-IL-1 Receptor Domain-Containing Adapter Protein Mediate Toll-Like Receptor 4 Induction of HIV-Long Terminal Repeat J. Immunol., June 15, 2004; 172(12): 7642 - 7646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Catley, L. M. Cambridge, Y. Nasuhara, K. Ito, J. E. Chivers, A. Beaton, N. S. Holden, M. W. Bergmann, P. J. Barnes, and R. Newton Inhibitors of Protein Kinase C (PKC) Prevent Activated Transcription: ROLE OF EVENTS DOWNSTREAM OF NF-{kappa}B DNA BINDING J. Biol. Chem., April 30, 2004; 279(18): 18457 - 18466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takamura, Y. Nasuhara, M. Kobayashi, T. Betsuyaku, Y. Tanino, I. Kinoshita, E. Yamaguchi, S. Matsukura, R. P. Schleimer, and M. Nishimura Retinoic acid inhibits interleukin-4-induced eotaxin production in a human bronchial epithelial cell line Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L777 - L785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Wong, W. K. Ip, and C. W. K. Lam Interleukin-3, -5, and Granulocyte Macrophage Colony-Stimulating Factor-Induced Adhesion Molecule Expression on Eosinophils by p38 Mitogen-Activated Protein Kinase and Nuclear Factor-{kappa}B Am. J. Respir. Cell Mol. Biol., July 1, 2003; 29(1): 133 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-L. Chen, Q. Zhang, R. Zhao, X. Ding, P. E. Tummala, and R. M. Medford Rac1 and Superoxide Are Required for the Expression of Cell Adhesion Molecules Induced by Tumor Necrosis Factor-alpha in Endothelial Cells J. Pharmacol. Exp. Ther., May 1, 2003; 305(2): 573 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tsutsumi-Ishii and I. Nagaoka Modulation of Human {beta}-Defensin-2 Transcription in Pulmonary Epithelial Cells by Lipopolysaccharide-Stimulated Mononuclear Phagocytes Via Proinflammatory Cytokine Production J. Immunol., April 15, 2003; 170(8): 4226 - 4236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Masamune, M. Satoh, K. Kikuta, Y. Sakai, A. Satoh, and T. Shimosegawa Inhibition of p38 Mitogen-Activated Protein Kinase Blocks Activation of Rat Pancreatic Stellate Cells J. Pharmacol. Exp. Ther., January 1, 2003; 304(1): 8 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D W Hommes, M P Peppelenbosch, and S J H van Deventer Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets Gut, January 1, 2003; 52(1): 144 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bernal-Mizrachi, W. Wen, M. Shornick, and M. A. Permutt Activation of Nuclear Factor-{kappa}B by Depolarization and Ca2+ Influx in MIN6 Insulinoma Cells Diabetes, December 1, 2002; 51(90003): S484 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mokros, A. Rehm, J. Droese, M. Oppermann, M. Lipp, and U. E. Hopken Surface Expression and Endocytosis of the Human Cytomegalovirus-encoded Chemokine Receptor US28 Is Regulated by Agonist-independent Phosphorylation J. Biol. Chem., November 15, 2002; 277(47): 45122 - 45128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, P. E. Massa, A. Hanidu, G. W. Peet, P. Aro, A. Savitt, S. Mische, J. Li, and K. B. Marcu IKKalpha , IKKbeta , and NEMO/IKKgamma Are Each Required for the NF-kappa B-mediated Inflammatory Response Program J. Biol. Chem., November 15, 2002; 277(47): 45129 - 45140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. Coward, Y. Okayama, H. Sagara, S. J. Wilson, S. T. Holgate, and M. K. Church NF-{kappa}B and TNF-{alpha}: A Positive Autocrine Loop in Human Lung Mast Cells? J. Immunol., November 1, 2002; 169(9): 5287 - 5293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Qin, T. Nguyen, J. Stewart, I. Samudio, R. Burghardt, and S. Safe Estrogen Up-Regulation of p53 Gene Expression in MCF-7 Breast Cancer Cells Is Mediated by Calmodulin Kinase IV-Dependent Activation of a Nuclear Factor {kappa}B/CCAAT-Binding Transcription Factor-1 Complex Mol. Endocrinol., August 1, 2002; 16(8): 1793 - 1809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Mancuso, A. Midiri, C. Beninati, G. Piraino, A. Valenti, G. Nicocia, D. Teti, J. Cook, and G. Teti Mitogen-Activated Protein Kinases and NF-{kappa}B Are Involved in TNF-{alpha} Responses to Group B Streptococci J. Immunol., August 1, 2002; 169(3): 1401 - 1409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Oudin and J. Pugin Role of MAP Kinase Activation in Interleukin-8 Production by Human BEAS-2B Bronchial Epithelial Cells Submitted to Cyclic Stretch Am. J. Respir. Cell Mol. Biol., July 1, 2002; 27(1): 107 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Knuefermann, P. Chen, A. Misra, S.-P. Shi, M. Abdellatif, and N. Sivasubramanian Myotrophin/V-1, a Protein Up-regulated in the Failing Human Heart and in Postnatal Cerebellum, Converts NFkappa B p50-p65 Heterodimers to p50-p50 and p65-p65 Homodimers J. Biol. Chem., June 21, 2002; 277(26): 23888 - 23897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Hagood, A. Mangalwadi, B. Guo, M. W. MacEwen, L. Salazar, and G. M. Fuller Concordant and Discordant Interleukin-1-Mediated Signaling in Lung Fibroblast Thy-1 Subpopulations Am. J. Respir. Cell Mol. Biol., June 1, 2002; 26(6): 702 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Muller, A. Morotti, and C. Ponzetto Activation of NF-{kappa}B Is Essential for Hepatocyte Growth Factor-Mediated Proliferation and Tubulogenesis Mol. Cell. Biol., February 15, 2002; 22(4): 1060 - 1072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Cowling, D. Gurantz, J. Peng, W. H. Dillmann, and B. H. Greenberg Transcription Factor NF-kappa B Is Necessary for Up-regulation of Type 1 Angiotensin II Receptor mRNA in Rat Cardiac Fibroblasts Treated with Tumor Necrosis Factor-alpha or Interleukin-1beta J. Biol. Chem., February 15, 2002; 277(8): 5719 - 5724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Pandey, H.-J. He, A. Chesley, M. Juhaszova, M. T. Crow, and M. Bernier Wortmannin-Sensitive Pathway Is Required for Insulin-Stimulated Phosphorylation of Inhibitor {kappa}B{alpha} Endocrinology, February 1, 2002; 143(2): 375 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sizemore, N. Lerner, N. Dombrowski, H. Sakurai, and G. R. Stark Distinct Roles of the Ikappa B Kinase alpha and beta Subunits in Liberating Nuclear Factor kappa B (NF-kappa B) from Ikappa B and in Phosphorylating the p65 Subunit of NF-kappa B J. Biol. Chem., February 1, 2002; 277(6): 3863 - 3869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Krappmann, A. Patke, V. Heissmeyer, and C. Scheidereit B-Cell Receptor- and Phorbol Ester-Induced NF-{kappa}B and c-Jun N-Terminal Kinase Activation in B Cells Requires Novel Protein Kinase C's Mol. Cell. Biol., October 1, 2001; 21(19): 6640 - 6650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jefferies, A. Bowie, G. Brady, E.-L. Cooke, X. Li, and L. A. J. O'Neill Transactivation by the p65 Subunit of NF-{kappa}B in Response to Interleukin-1 (IL-1) Involves MyD88, IL-1 Receptor-Associated Kinase 1, TRAF-6, and Rac1 Mol. Cell. Biol., July 15, 2001; 21(14): 4544 - 4552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Yeh, L. Sturgis, J. Haidacher, X.-N. Zhang, S. J. Sherwood, R. J. Bjercke, O. Juhasz, M. T. Crow, R. G. Tilton, and L. Denner Requirement for p38 and p44/p42 Mitogen-Activated Protein Kinases in RAGE-Mediated Nuclear Factor-{kappa}B Transcriptional Activation and Cytokine Secretion Diabetes, June 1, 2001; 50(6): 1495 - 1504. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-W. Hsu, K.-H. Chi, W.-C. Huang, and W.-W. Lin Ceramide Inhibits Lipopolysaccharide-Mediated Nitric Oxide Synthase and Cyclooxygenase-2 Induction in Macrophages: Effects on Protein Kinases and Transcription Factors J. Immunol., May 1, 2001; 166(9): 5388 - 5397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-C. Chen, J.-J. Chen, and C.-Y. Chou Protein Kinase Calpha but not p44/42 Mitogen-Activated Protein Kinase, p38, or c-Jun NH2-Terminal Kinase Is Required for Intercellular Adhesion Molecule-1 Expression Mediated by Interleukin-1beta : Involvement of Sequential Activation of Tyrosine Kinase, Nuclear Factor-kappa B-Inducing Kinase, and Ikappa B Kinase 2 Mol. Pharmacol., April 13, 2001; 58(6): 1479 - 1489. [Abstract] [Full Text]
|
|
|
|
|
|
M. Goebeler, R. Gillitzer, K. Kilian, K. Utzel, E.-B. Brocker, U. R. Rapp, and S. Ludwig Multiple signaling pathways regulate NF-{kappa}B-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells Blood, January 1, 2001; 97(1): 46 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Vallejo, P. Knuefermann, D. L. Mann, and N. Sivasubramanian Group B Streptococcus Induces TNF-{alpha} Gene Expression and Activation of the Transcription Factors NF-{kappa}B and Activator Protein-1 in Human Cord Blood Monocytes J. Immunol., July 1, 2000; 165(1): 419 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ruiz-Ortega, O. Lorenzo, M. Rupérez, S. König, B. Wittig, and J. Egido Angiotensin II Activates Nuclear Transcription Factor {kappa}B Through AT1 and AT2 in Vascular Smooth Muscle Cells : Molecular Mechanisms Circ. Res., June 23, 2000; 86(12): 1266 - 1272. [Abstract] [Full Text]
|
|
|
|
|
|
M. Bergmann, P. J. Barnes, and R. Newton Molecular Regulation of Granulocyte Macrophage Colony-Stimulating Factor in Human Lung Epithelial Cells by Interleukin (IL)-1beta , IL-4, and IL-13 Involves Both Transcriptional and Post-Transcriptional Mechanisms Am. J. Respir. Cell Mol. Biol., May 1, 2000; 22(5): 582 - 589. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. Jiang and P. Brecher N-Acetyl-L-Cysteine Potentiates Interleukin-1{beta} Induction of Nitric Oxide Synthase : Role of p44/42 Mitogen-Activated Protein Kinases Hypertension, April 1, 2000; 35(4): 914 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Oda, K. Sakitani, M. Kaibori, T. Inoue, Y. Kamiyama, and T. Okumura Vicinal Dithiol-binding Agent, Phenylarsine Oxide, Inhibits Inducible Nitric-oxide Synthase Gene Expression at a Step of Nuclear Factor-kappa B DNA Binding in Hepatocytes J. Biol. Chem., February 11, 2000; 275(6): 4369 - 4373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tetsuka, H. Uranishi, H. Imai, T. Ono, S.-i. Sonta, N. Takahashi, K. Asamitsu, and T. Okamoto Inhibition of Nuclear Factor-kappa B-mediated Transcription by Association with the Amino-terminal Enhancer of Split, a Groucho-related Protein Lacking WD40 Repeats J. Biol. Chem., February 11, 2000; 275(6): 4383 - 4390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Jefferies and L. A. J. O'Neill Rac1 Regulates Interleukin 1-induced Nuclear Factor kappa B Activation in an Inhibitory Protein kappa Balpha -independent Manner by Enhancing the Ability of the p65 Subunit to Transactivate Gene Expression J. Biol. Chem., February 4, 2000; 275(5): 3114 - 3120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Han and C. D. Logsdon CCK stimulates mob-1 expression and NF-kappa B activation via protein kinase C and intracellular Ca2+ Am J Physiol Cell Physiol, February 1, 2000; 278(2): C344 - C351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Dorsam, M. M. Taher, K. C. Valerie, N. B. Kuemmerle, J. C. Chan, and R. C. Franson Diphenyleneiodium Chloride Blocks Inflammatory Cytokine-Induced Up-Regulation of Group IIA Phospholipase A2 in Rat Mesangial Cells J. Pharmacol. Exp. Ther., January 1, 2000; 292(1): 271 - 279. [Abstract] [Full Text]
|
|
|
|
|
|
F. Carlotti, R. Chapman, S. K. Dower, and E. E. Qwarnstrom Activation of Nuclear Factor kappa B in Single Living Cells. DEPENDENCE OF NUCLEAR TRANSLOCATION AND ANTI-APOPTOTIC FUNCTION ON EGFPRELA CONCENTRATION J. Biol. Chem., December 31, 1999; 274(53): 37941 - 37949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Guan, S. Y. Buckman, L. D. Springer, and A. R. Morrison Both p38alpha MAPK and JNK/SAPK Pathways Are Important for Induction of Nitric-oxide Synthase by Interleukin-1beta in Rat Glomerular Mesangial Cells J. Biol. Chem., December 17, 1999; 274(51): 36200 - 36206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Jaspers, J. M. Samet, and W. Reed Arsenite Exposure of Cultured Airway Epithelial Cells Activates kappa B-dependent Interleukin-8 Gene Expression in the Absence of Nuclear Factor-kappa B Nuclear Translocation J. Biol. Chem., October 22, 1999; 274(43): 31025 - 31033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Holtmann, R. Winzen, P. Holland, S. Eickemeier, E. Hoffmann, D. Wallach, N. L. Malinin, J. A. Cooper, K. Resch, and M. Kracht Induction of Interleukin-8 Synthesis Integrates Effects on Transcription and mRNA Degradation from at Least Three Different Cytokine- or Stress-Activated Signal Transduction Pathways Mol. Cell. Biol., October 1, 1999; 19(10): 6742 - 6753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vlahopoulos, I. Boldogh, A. Casola, and A. R. Brasier Nuclear Factor-kappa B-Dependent Induction of Interleukin-8 Gene Expression by Tumor Necrosis Factor alpha : Evidence for an Antioxidant Sensitive Activating Pathway Distinct From Nuclear Translocation Blood, September 15, 1999; 94(6): 1878 - 1889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nasuhara, I. M. Adcock, M. Catley, P. J. Barnes, and R. Newton Differential Ikappa B Kinase Activation and Ikappa Balpha Degradation by Interleukin-1beta and Tumor Necrosis Factor-alpha in Human U937 Monocytic Cells. EVIDENCE FOR ADDITIONAL REGULATORY STEPS IN kappa B-DEPENDENT TRANSCRIPTION J. Biol. Chem., July 9, 1999; 274(28): 19965 - 19972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, M. Commane, C. Burns, K. Vithalani, Z. Cao, and G. R. Stark Mutant Cells That Do Not Respond to Interleukin-1 (IL-1) Reveal a Novel Role for IL-1 Receptor-Associated Kinase Mol. Cell. Biol., July 1, 1999; 19(7): 4643 - 4652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sizemore, S. Leung, and G. R. Stark Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-kappa B p65/RelA Subunit Mol. Cell. Biol., July 1, 1999; 19(7): 4798 - 4805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 |
