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J Biol Chem, Vol. 273, Issue 13, 7228-7234, March 27, 1998
From the "Stress-regulated" mitogen-activated protein
kinases (SR-MAPKs) comprise the stress-activated protein kinases
(SAPKs)/c-Jun N-terminal kinases (JNKs) and the p38-MAPKs. In the
perfused heart, ischemia/reperfusion activates SR-MAPKs. Although the
agent(s) directly responsible is unclear, reactive oxygen species are
generated during ischemia/reperfusion. We have assessed the ability of
oxidative stress (as exemplified by H2O2)
to activate SR-MAPKs in the perfused heart and compared it with the
effect of ischemia/reperfusion. H2O2 activated
both SAPKs/JNKs and p38-MAPK. Maximal activation by
H2O2 in both cases was observed at 0.5 mM. Whereas activation of p38-MAPK by
H2O2 was comparable to that of ischemia and
ischemia/reperfusion, activation of the SAPKs/JNKs was less than that
of ischemia/reperfusion. As with ischemia/reperfusion, there was
minimal activation of the ERK MAPK subfamily by
H2O2. MAPK-activated protein kinase 2 (MAPKAPK2), a downstream substrate of p38-MAPKs, was activated by
H2O2 to a similar extent as with ischemia or
ischemia/reperfusion. In all instances, activation of MAPKAPK2 in
perfused hearts was inhibited by SB203580, an inhibitor of p38-MAPKs.
Perfusion of hearts at high aortic pressure (20 kilopascals) also
activated the SR-MAPKs and MAPKAPK2. Free radical trapping agents
(dimethyl sulfoxide and N-t-butyl-
Stimulation of "Stress-regulated" Mitogen-activated Protein
Kinases (Stress-activated Protein Kinases/c-Jun N-terminal Kinases
and p38-Mitogen-activated Protein Kinases) in Perfused Rat
Hearts by Oxidative and Other Stresses
§,,, and
National Heart and Lung Institute Division,
Imperial College School of Medicine, Royal Brompton Campus, London SW3
6LY, United Kingdom and the § Division of Biomedical
Sciences, Imperial College School of Medicine, Charing Cross Campus,
London W6 8RF, United Kingdom
-phenyl nitrone)
inhibited the activation of SR-MAPKs and MAPKAPK2 by
ischemia/reperfusion. These data are consistent with a role for
reactive oxygen species in the activation of SR-MAPKs during
ischemia/reperfusion.
Copyright © 1998 by The American Society for Biochemistry and Molecular Biology, Inc.
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|
|
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|
|
|
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|
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|
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|
|
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